scholarly journals Ante-Natal and Post-Natal Influences on Neonatal Immunity, Growth and Puberty of Calves—A Review

Animals ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1212
Author(s):  
Claudia L. Cardoso ◽  
Ailbhe King ◽  
Aspinas Chapwanya ◽  
Giulia Esposito
Keyword(s):  
Immune Responses ◽  
Maternal Nutrition ◽  
Optimal Growth ◽  
Dairy Calves ◽  
Factors Affecting ◽  
Future Performance ◽  
Neonatal Immunity ◽  
Neonatal Nutrition ◽  
Environmental Pathogens ◽  
Calf Rearing

Calf immunity, growth and puberty are important factors affecting heifer productivity. The first four weeks of age are critical for reducing calf morbidity and mortality. It is well documented that colostrum is paramount to neonatal nutrition and passive immunity, however, adaptation to extra-uterine life starts early during embryonic development. Therefore, successful calf rearing strategies are underpinned by adequate maternal nutrition during gestation, and good colostrum management. A deeper understanding of these interactions paves the way for developing strategies to improve immune responses to environmental pathogens, optimal growth and timely attainment of puberty in calves. The literature reviewed here shows that there are opportunities to enhance the future performance of cattle paying attention to the interaction of nutrition and immunity at each developmental stage. Therefore, the objective of this review is to give the reader an overview of interactions between immunity, growth and puberty in dairy calves and highlight how these influence future performances.

scholarly journals Oxidative Stress Compromises Lymphocyte Function in Neonatal Dairy Calves

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 255
Author(s):  
Wilmer Cuervo ◽  
Lorraine M. Sordillo ◽  
Angel Abuelo
Keyword(s):  
Oxidative Stress ◽  
Immune Responses ◽  
Immune Cell ◽  
Lymphocyte Activation ◽  
Dairy Calves ◽  
Lymphocyte Function ◽  
Newborn Calves ◽  
Ifn Γ ◽  
The Impact

Dairy calves are unable to mount an effective immune response during their first weeks of life, which contributes to increased disease susceptibility during this period. Oxidative stress (OS) diminishes the immune cell capabilities of humans and adult cows, and dairy calves also experience OS during their first month of life. However, the impact that OS may have on neonatal calf immunity remains unexplored. Thus, we aimed to evaluate the impact of OS on newborn calf lymphocyte functions. For this, we conducted two experiments. First, we assessed the association of OS status throughout the first month of age and the circulating concentrations of the cytokines interferon-gamma (IFN-γ) and interleukin (IL) 4, as well as the expression of cytokine-encoding genes IFNG, IL2, IL4, and IL10 in peripheral mononuclear blood cells (PBMCs) of 12 calves. Subsequently, we isolated PBMCs from another 6 neonatal calves to investigate in vitro the effect of OS on immune responses in terms of activation of lymphocytes, cytokine expression, and antibody production following stimulation with phorbol 12-myristate 13-acetate or bovine herpesvirus-1. The results were compared statistically through mixed models. Calves exposed to high OS status in their first month of age showed higher concentrations of IL-4 and expression of IL4 and IL10 and lower concentrations of IFN-γ and expression of IFNG and IL2 than calves exposed to lower OS. In vitro, OS reduced lymphocyte activation, production of antibodies, and protein and gene expression of key cytokines. Collectively, our results demonstrate that OS can compromise some immune responses of newborn calves. Hence, further studies are needed to explore the mechanisms of how OS affects the different lymphocyte subsets and the potential of ameliorating OS in newborn calves as a strategy to augment the functional capacity of calf immune cells, as well as enhance calves’ resistance to infections.

scholarly journals Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1272
Author(s):  
Anita Ioana Visan ◽  
Gianina Popescu-Pelin ◽  
Gabriel Socol
Keyword(s):  
Drug Delivery ◽  
Degradation Mechanism ◽  
Degradation Behavior ◽  
Polymeric Coatings ◽  
Degradation Mechanisms ◽  
Coating Materials ◽  
Factors Affecting ◽  
Existing Problems ◽  
Future Performance ◽  
Measuring Techniques

The purpose of the work was to emphasize the main differences and similarities in the degradation mechanisms in the case of polymeric coatings compared with the bulk ones. Combined with the current background, this work reviews the properties of commonly utilized degradable polymers in drug delivery, the factors affecting degradation mechanism, testing methods while offering a retrospective on the evolution of the controlled release of biodegradable polymeric coatings. A literature survey on stability and degradation of different polymeric coatings, which were thoroughly evaluated by different techniques, e.g., polymer mass loss measurements, surface, structural and chemical analysis, was completed. Moreover, we analyzed some shortcomings of the degradation behavior of biopolymers in form of coatings and briefly proposed some solving directions to the main existing problems (e.g., improving measuring techniques resolution, elucidation of complete mathematical analysis of the different degradation mechanisms). Deep studies are still necessary on the dynamic changes which occur to biodegradable polymeric coatings which can help to envisage the future performance of synthesized films designed to be used as medical devices with application in drug delivery.

131 Can Maternal Nutrition in Dairy Cattle Impact Gut Health in Dairy Calves?

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 69-70
Author(s):  
Lautaro Rostoll Cangiano ◽  
Nilusha Malmuthuge ◽  
Tao Ma ◽  
Leluo Guan ◽  
Michael A Steele
Keyword(s):  
Developmental Plasticity ◽  
Maternal Nutrition ◽  
Critical Role ◽  
Dairy Calves ◽  
Milk Replacer ◽  
Gastrointestinal Function ◽  
Dairy Calf ◽  
Gastrointestinal Health ◽  
Nutrition Research ◽  
Pregnancy And Postpartum

Abstract The nutritional management, health and welfare of the dairy calf has historically received less attention due to limited research, and recommendations largely focused on passive transfer of immunity and early weaning strategies. Gastrointestinal diseases and disorders remain the leading cause of mortality and morbidity in dairy calves worldwide. Despite the recent thrust in dairy calf nutrition research, major knowledge gaps still exist regarding how maternal nutrition during pregnancy and postpartum impact gastrointestinal health and function, especially during the fetal and neonatal stages when the developmental plasticity is highest. Recent research has focused on how prepartum nutrition and management can influence colostrum quality and has characterized numerous bioactive proteins, lipids, and carbohydrates that may play a critical role in gastrointestinal function and development. It has also been shown that colostrum plays a fundamental role in promoting colonization with commensal bacteria; however, delaying colostrum feeding or abruptly transitioning calves from colostrum to milk decreased the colonization of beneficial bacteria and impaired gastrointestinal development. With respect to the maternal nutrient supply via milk, it is important to note that calves have been traditionally fed less than half of voluntary intake or fed milk replacer formulations that can largely differ in composition from that of maternal milk. Recent research indicated that common milk replacer formulations may impair gastrointestinal function, highlighting the need to question existing nutritional regimens. In addition, feeding prophylactic antibiotics in milk, as well as waste milk containing antibiotic residues, are common practices in the dairy industry, despite recent studies reporting that these practices can increase calf susceptibility to infections by disrupting gut microbiome and gut function. Although our knowledge how maternal factors impact the gastrointestinal tract of calves is limited, it is clear there are great opportunities to further develop prenatal and postnatal nutritional programs to improve dairy calf gastrointestinal health.

Pharmaceutical Innovation in the United States: Factors Affecting Future Performance

1993 ◽  
Vol 9 (2) ◽  
pp. 167-173 ◽  
Author(s):  
Michael R. Pollard
Keyword(s):  
United States ◽  
Pharmaceutical Industry ◽  
Research And Development ◽  
Cost Containment ◽  
The United States ◽  
Private Companies ◽  
Factors Affecting ◽  
The Past ◽  
Future Performance ◽  
Regulatory Strategy

AbstractFueled by high returns on its investments, the pharmaceutical industry in the United States has flourished for the past 50 years. The regulatory strategy of demanding stringent testing then allowing market-based pricing has allowed private companies to fund ambitious research and development activities with the assurance that these investments will be recovered. However, aggressive managed-care cost-containment strategies threaten the companies' ability to recoup research and development expenses and may affect their willingness to invest in future innovative research.

Electoral Performance by Post-Rebel Parties

2018 ◽  
Vol 54 (3) ◽  
pp. 415-453 ◽  
Author(s):  
Carrie Manning ◽  
Ian Smith
Keyword(s):  
Legislative Elections ◽  
Full Data ◽  
Data Set ◽  
Factors Affecting ◽  
Future Performance ◽  
Organizational Experience ◽  
Varying Length ◽  
New Research ◽  
Electoral Performance ◽  
Positive Effect

This article explores the factors affecting post-rebel party electoral performance. We present new research tracking the participation of these groups in national legislative elections from 1990 to 2016. Our full data set covers 77 parties and 286 elections in 37 countries. It includes parties formed after conflicts of varying length and intensity, with different incompatibilities, in every region of the world, and in countries with disparate political histories. Our analysis suggests that post-rebel parties’ early electoral performance strongly affects future performance, and that competition – crowd-out by older rival parties – and pre-war organizational experience in politics have a significant positive effect, particularly for those parties that are consistently winning more than about 10 per cent of seats. But especially for parties that consistently win very low seat shares, organizational characteristics yield increasingly to environmental factors, most importantly the presence of rival parties and the barriers to representation presented by electoral rules.

Advances in understanding behavioral needs and improving the welfare of calves and heifers

2021 ◽  
pp. 163-198
Author(s):  
Emily Miller-Cushon ◽  
◽  
Jennifer Van Os ◽  
Keyword(s):  
Individual Differences ◽  
Social Contact ◽  
Dairy Calves ◽  
Environmental Complexity ◽  
Factors Affecting ◽  
Dietary Variety ◽  
Behavioral Expression ◽  
Behavioral Needs ◽  
And Performance

Management factors affecting dairy calves have broad impacts on behavioral development and implications for long-term welfare, and research in this area is increasingly focused on understanding the behavioral needs of the calf, to refine management and improve understanding of welfare. In this chapter, we summarize recent research addressing behavioral needs of pre-weaned calves and post-weaned heifers, encompassing aspects of social interactions and feeding, rest and comfort, and opportunities for other behavioral expression. In general, evidence suggests welfare and performance benefits of accommodating more natural behavioral expression, including social contact, higher milk intakes fed via a teat, dietary variety, and space and resources to accommodate preferred activities, such as grooming and play. Throughout these sections, consequences of restricting these behaviors includes development of abnormal oral behaviors. Emerging themes of this area of research include consideration of individual differences and implications and approaches to accommodate broader behavioral expression through increasing environmental complexity.

scholarly journals Genetic and Physiological Factors Affecting Human Milk Production and Composition

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1500
Author(s):  
Yarden Golan ◽  
Yehuda G. Assaraf
Keyword(s):  
Human Milk ◽  
Maternal Nutrition ◽  
Genetic Diagnosis ◽  
Genetic Variations ◽  
Nutrition Status ◽  
Treatment Modalities ◽  
Future Perspective ◽  
Physiological Factors ◽  
Factors Affecting ◽  
Intrinsic Factors

Human milk is considered the optimal nutrition for infants as it provides additional attributes other than nutritional support for the infant and contributes to the mother’s health as well. Although breastfeeding is the most natural modality to feed infants, nowadays, many mothers complain about breastfeeding difficulties. In addition to environmental factors that may influence lactation outcomes including maternal nutrition status, partner’s support, stress, and latching ability of the infant, intrinsic factors such as maternal genetics may also affect the quantitative production and qualitative content of human milk. These genetic factors, which may largely affect the infant’s growth and development, as well as the mother’s breastfeeding experience, are the subject of the present review. We specifically describe genetic variations that were shown to affect quantitative human milk supply and/or its qualitative content. We further discuss possible implications and methods for diagnosis as well as treatment modalities. Although cases of nutrient-deficient human milk are considered rare, in some ethnic groups, genetic variations that affect human milk content are more abundant, and they should receive greater attention for diagnosis and treatment when necessary. From a future perspective, early genetic diagnosis should be directed to target and treat breastfeeding difficulties in real time.

A review of factors affecting cave climates for hibernating bats in temperate North America

2013 ◽  
Vol 21 (1) ◽  
pp. 28-39 ◽  
Author(s):  
Roger W. Perry
Keyword(s):  
North America ◽  
Energy Savings ◽  
Optimal Growth ◽  
Water Infiltration ◽  
Evaporative Water ◽  
Factors Affecting ◽  
Geomyces Destructans ◽  
Thermal Requirements ◽  
White Nose Syndrome ◽  
Air Infiltration

The fungal pathogen Geomyces destructans, which causes white-nose syndrome in bats, thrives in the cold and moist conditions found in caves where bats hibernate. To aid managers and researchers address this disease, an updated and accessible review of cave hibernacula and cave microclimates is presented. To maximize energy savings and reduce evaporative water loss during winter, most temperate vespertilionid bats in North America select caves with temperatures between 2 and 10 °C, with 60%–100% relative humidity. Generally, the temperature in caves is similar to the mean annual surface temperature (MAST) of a region, which varies by latitude, altitude, and topography. However, MAST for most areas where caves are found in eastern North America is well above 10 °C. Thus, various factors cause cold-air infiltration that reduces temperatures of these caves during winter. These factors include depth of cave, topographic setting, airflow patterns, cave configuration, and water infiltration. Factors affecting humidity, condensation, and evaporation are also addressed. In areas where MAST is above or below the thermal requirements of Geomyces destructans, many caves used by bats as hibernacula may still provide favorable sites for optimal growth of this fungus.

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