scholarly journals Analysis of Candidate Genes for Growth and Milk Performance Traits in the Egyptian Barki Sheep

Animals ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 197
Author(s):  
Ibrahim Abousoliman ◽  
Henry Reyer ◽  
Michael Oster ◽  
Eduard Muráni ◽  
Mosaad Mourad ◽  
...  
Keyword(s):  
Candidate Genes ◽  
Growth Traits ◽  
Average Daily Gain ◽  
Economic Value ◽  
Production Traits ◽  
Coding Region ◽  
Milk Traits ◽  
Milk Performance ◽  
Study Association ◽  
Lamb Growth

The most common sheep breeds of Egypt are Ossimi, Rahmani, and Barki breeds. The latter one is well adapted to the challenging desert environment, characterized by food shortage and a high temperature fluctuation. Growth performance of Barki sheep has an important economic value in terms of minimizing the shortage of mutton meat in Egypt. Further, milk production is of great importance for feeding newborn lambs. Eight candidate genes, recently associated with production traits in different breeds, were used to study the effect of genotype on lamb growth and ewe milk traits. The examined genes were LEP, IGF1, DGAT1, STAT5A, PRL, CSN1S2, GHR, and GHRHR, of which one representative single nucleotide polymorphism (SNP) located in the coding region was selected for genotyping. Data from 251 Barki sheep were used in this study. Association analysis between SNPs and lamb growth traits identified rs420693815 of the LEP gene to be significantly associated with weaning weight and average daily gain. In ewes, significant effects on milk yield and composition have been estimated for LEP (rs420693815), STAT5A (rs161082816), PRL (rs422713690), and GHRHR (rs414991449). The results indicated that these genes might be considered as interesting candidates for further investigations to improve growth and milk performance in Barki sheep.

scholarly journals Weighted Single-Step GWAS Identified Candidate Genes Associated with Growth Traits in a Duroc Pig Population

Genes ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 117
Author(s):  
Donglin Ruan ◽  
Zhanwei Zhuang ◽  
Rongrong Ding ◽  
Yibin Qiu ◽  
Shenping Zhou ◽  
...  
Keyword(s):  
Candidate Genes ◽  
Bone Growth ◽  
Genome Wide Association Study ◽  
Growth Traits ◽  
Average Daily Gain ◽  
Snp Array ◽  
Single Step ◽  
Economic Traits ◽  
Association Analyses ◽  
Genealogical Information

Growth traits are important economic traits of pigs that are controlled by several major genes and multiple minor genes. To better understand the genetic architecture of growth traits, we performed a weighted single-step genome-wide association study (wssGWAS) to identify genomic regions and candidate genes that are associated with days to 100 kg (AGE), average daily gain (ADG), backfat thickness (BF) and lean meat percentage (LMP) in a Duroc pig population. In this study, 3945 individuals with phenotypic and genealogical information, of which 2084 pigs were genotyped with a 50 K single-nucleotide polymorphism (SNP) array, were used for association analyses. We found that the most significant regions explained 2.56–3.07% of genetic variance for four traits, and the detected significant regions (>1%) explained 17.07%, 18.59%, 23.87% and 21.94% for four traits. Finally, 21 genes that have been reported to be associated with metabolism, bone growth, and fat deposition were treated as candidate genes for growth traits in pigs. Moreover, gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses implied that the identified genes took part in bone formation, the immune system, and digestion. In conclusion, such full use of phenotypic, genotypic, and genealogical information will accelerate the genetic improvement of growth traits in pigs.

Analysis of porcine OSBPL5 gene allelic expression in skeletal muscle and association of a single-nucleotide polymorphism in the coding region with production traits

2019 ◽  
Vol 99 (4) ◽  
pp. 914-920
Author(s):  
Meng Wang ◽  
Deli Wei ◽  
Guiling Cao ◽  
Guiyu Zhu ◽  
Yunliang Jiang
Keyword(s):  
Skeletal Muscle ◽  
Single Nucleotide Polymorphism ◽  
Growth Regulation ◽  
Average Daily Gain ◽  
Allelic Expression ◽  
Production Traits ◽  
Coding Region ◽  
Nucleotide Polymorphism ◽  
Specific Expression ◽  
Single Nucleotide

Genes that exhibit allelic expression imbalance and imprinted genes play important roles in the survival of the embryo and postnatal growth regulation. In this study, the porcine oxysterol-binding protein-related 5 (OSBPL5) gene was examined, and the 2140G>A mutation (rs318687202) was found in its coding region by a comparison of Laiwu and Landrace pigs. By allele-specific expression analysis based on a specific single-nucleotide polymorphism (SNP), the imprinting status of OSBPL5 gene in skeletal muscle from both neonate and adult pigs was determined. The results showed that the OSBPL5 was paternally imprinted in skeletal muscle from adults but biallelically expressed with predominantly maternal imprinting in neonates. The distribution of the 2140G>A SNP in four pig populations was analyzed, which showed that GG genotype was dominant in Duroc and Dapulian populations, whereas the AG genotype was dominant in Junmu-1 and Laiwu populations. Pigs with the GG genotype had significantly larger litters and greater cannon bone circumferences but a lower average daily gain than pigs with the AA genotype. In conclusion, we determined the difference in the allelic expression of OSBPL5 between adult and neonate pigs and identified an SNP in its coding region that is associated with production traits.

scholarly journals Polymorphisms of the PRLR Gene and Their Association with Milk Production Traits in Egyptian Buffaloes

Animals ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1237
Author(s):  
Mohammed A. El-Magd ◽  
Aziza Fathy ◽  
Khaled A. Kahilo ◽  
Ayman A. Saleh ◽  
Ahmed I. El Sheikh ◽  
...  
Keyword(s):  
Milk Production ◽  
Association Studies ◽  
Single Strand Conformation Polymorphism ◽  
Nucleotide Polymorphisms ◽  
Production Traits ◽  
Milk Production Traits ◽  
Milk Traits ◽  
Water Buffaloes ◽  
Protein Levels ◽  
Milk Performance

Prolactin (PRL) and its receptor (PRLR) were considered as potential genetic markers for milk production and quality traits in cattle. However, little information is available regarding PRLR genetic diversity and association studies with milk traits in Egyptian water buffaloes. Therefore, the present study was conducted to search for mutations in PRLR and determine their associations with milk performance in these animals. Exon3 (E3) and E10 of PRLR were screened for polymorphisms using single strand conformation polymorphism (SSCP) and sequencing in 400 buffaloes. The associations between haplotypes and milk production (fat%, protein%, lactose%, and solid%) traits as well as mRNA and protein levels of PRL and PRLR were studied. Two single nucleotide polymorphisms (SNPs) in E10 were detected: g.11685G>A (p.Ala494Thr) and g.11773T>C (p.Val523Aal). The G and T alleles were wild (ancestral) alleles, while the A and C alleles were mutant alleles. These SNPs resulted in four haplotypes; AC, AT, GC, and GT. Buffaloes with wild GT haplotypes showed significantly higher milk yield, fat% and protein%, mRNA and protein levels of PRL and PRLR in milk somatic cells than other animals. Animals carrying mutant AC haplotype had inferior milk traits and lowest levels of associated mRNAs and proteins. With these results, we could conclude that the selection of buffaloes with wild GT haplotypes for g.11685G>A and g.11773T>C SNPs of the PRLR gene might improve the milk production traits of Egyptian water buffaloes.

Possible relationship between IGF-1/SnaBI genotypes and milk yield of Holstein-Friesian cows

2019 ◽  
Vol 15 (4) ◽  
pp. 35-41
Author(s):  
Małgorzata WASIELEWSKA ◽  
Iwona SZATKOWSKA
Keyword(s):  
Milk Yield ◽  
Quality Characteristics ◽  
Production Traits ◽  
Performance Parameters ◽  
Milk Traits ◽  
White Variety ◽  
Black And White ◽  
Holstein Friesian ◽  
Milk Performance ◽  
Friesian Cows

The correlation between polymorphisms in the IGF-1 gene and production traits in beef cattle is well known. The effect of insulin-like growth factor on the value of milk traits is not yet adequately understood. The aim of the study was to attempt to describe the effect of IGF-1/SnaBI substitution on selected milk performance parameters of the Black-and-White variety of Holstein-Friesian cows. Three genotypes were identified: CC, CT and TT. The results showed a correlation between IGF-1/SnaBI genotypes and milk yield (highest for CC homozygotes and lowest for CT heterozygotes). No relationship could be established between the genotype and the quality characteristics of milk.

Short communication: The genotype of growth hormone gene that affects the birth weight and average daily gain in crossbred beef cattle

2020 ◽  
Vol 21 (3) ◽  
Author(s):  
Tety Hartatik ◽  
AHMAD FATHONI ◽  
SIGIT BINTARA ◽  
ISMAYA ◽  
PANJONO ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Birth Weight ◽  
Beef Cattle ◽  
Short Communication ◽  
Growth Traits ◽  
Average Daily Gain ◽  
Growth Hormone Gene ◽  
Production Traits ◽  
Significant Difference ◽  
Daily Gain

Abstract. Hartatik T., Fathoni A, Bintara S., Ismaya, Panjono, Widyobroto B.P, Agus A, Budisatria I.G.S, Leroy P. 2020. Short communication: The genotype of growth hormone gene that affects the birth weight and average daily gain in crossbred beef cattle. Biodiversitas 21: 941-945. Growth Hormone gene has been proposed to direct search for quantitative trait loci, and polymorphisms at these loci have been associated with several production traits in bovine. This research aimed to investigate the association of the genotype of partial growth hormone gene with birth weight and average daily gain in crossbred beef cattle. The materials of this research consist of 47 samples from four different breeds. Birth weight was measured just after calving delivery from the mother. The average daily gain was calculated from the period since birth weight to the second weight (90 days). Genotyping of the growth hormone gene was determined by the sequencing and PCR-RFLP method with the AluI restriction enzyme. The association between genotype and growth traits data was analyzed using analysis of variance (ANOVA) by RStudio version 1.1.383. The results showed the significantly different (P<0.001) in birth weight and average daily gain according to the different breed. Friesian Holstein breed showed the highest birth weight, followed by Belgian Blue Bull cross and others. The genotype valine/valine only occurs in Belgian blue bull cross and Wagyu bull cross cattle and showed moderate birth weight. Genotype affects birth weight significantly (P<0.001). The birth weight for genotype leucine/leucine, leucine/valine, and valine/valine was 34.82±18.13, 25.31±13.10, and 29.35±13.65, respectively. There was no significant difference in average daily genes according to the different genotypes. In conclusion, the growth hormone gene was probably one of the molecular genetics markers for excellent growth traits in different crossbred beef cattle.

scholarly journals  Impact of economic parameters on economic values in dairy sheep

2013 ◽  
Vol 58 (No. 1) ◽  
pp. 21-30 ◽  
Author(s):  
Z. Krupová ◽  
E. Krupa ◽  
M. Wolfová
Keyword(s):  
Milk Production ◽  
Litter Size ◽  
Functional Traits ◽  
Milk Yield ◽  
Growth Traits ◽  
Economic Value ◽  
Production Traits ◽  
Economic Values ◽  
Economic Parameters ◽  
The Impact

The impact of variation in economic conditions on the economic values of fourteen production and functional traits was examined for the Improved Valachian breed using a bio-economic model implemented in the ECOWEIGHT software. The following economic parameters were investigated: market prices of lambs, milk, and cheese (variation &plusmn; 40%), costs for roughage, concentrates, and total feeding rations , costs for labour and veterinary care, fixed costs (variation &plusmn; 20% for all costs), and discount rate of revenues and costs (0 and 3%). Results of the analyses were presented in detail for the marginal and relative economic values of the four most important traits: milk yield in the 150-day milking period, conception rate of ewes, litter size per lambed ewe, and productive lifetime of ewes. Furthermore, cumulative relative economic values of the four trait complexes &ndash; milk production, growth, functional, and wool traits &ndash; were presented. Prices for sheep products were found to be the most important factor for both the marginal and the relative economic values of the evaluated traits. The four traits with the highest relative economic values in the base calculation stayed the most important for all investigated economic parameters ranges. The relative economic values of the remaining 10 traits did not exceed 6.1%. The relative economic values of milk yield and litter size were the most sensitive to the variation in economic circumstances. For the investigated range of economic parameters, the relative economic value for the complex of milk production traits ranged 30.6&ndash;48.1%, for growth traits 6.3&ndash;9.4%, and that for functional traits 45.4&ndash;59.7%. The relative economic value for the wool trait did not exceed 0.3%.

scholarly journals Genetic Parameters For Milk Traits In Egyptian Native Cows

2021 ◽  
Author(s):  
Safaa Salah Sanad ◽  
Mahmod Ghreeb Gharib
Keyword(s):  
Genetic Parameters ◽  
Economic Value ◽  
Breeding Value ◽  
Lactation Period ◽  
Production Traits ◽  
Dry Period ◽  
Milk Traits ◽  
Local Breed ◽  
Breeding Values ◽  
National Wealth

Abstract The aim of this study is to estimate the genetic parameters and the effect of non-genetic factors for some milk traits including total milk yield (TMY/kg), Lactation period (LP/day), number of services per conception (NSC), days open (DO), calving interval (CI) and dry period (DP). Data were collected from two farms. Experimental Farm belonging to (APRI) data included 1829 records. The statistical analysis has been adopted using animal models. Actual means of TMY/kg, LP/day, NSC/services, DO/day, CI/day and DP/day were 791.3, 171.1, 1.8, 109, 402.7 and 79.3 respectively. Estimated heritability (h2) of TMY, LP, NSC, DO, CI, and DP were 0.18± 0.01, 0.18± 0.001, 0.07± 0.016, 0.09± 0.041 and 0.09±0.001 respectively. The ranges of breeding values BV of cows for TMY/kg, LP/day, NSC, /services, DO/day, CI/day and DP/day were 776.5, 26.7, 6.7, 13.4, 77.1 and 11.5 respectively. The estimated Predicted Breeding Value PBV for all traits varied widely. The genetic trends of cow breeding values were significant for all studied traits. This confirms that the genetic improvement of these traits leads to increased milk production traits. The study recommends preserving the Native Egyptian dairy cattle because they represent a national wealth that must be preserved from extinction through inventorying the genetic resources, characterization and evaluation of this local breed to benefit from it in improving animal breeds of high economic value. Due to the distinction of Egyptian domestic cows for their resistance to various environmental conditions.

Crossbreeding Jersey with Ghana Shorthorn and Sokoto Gudali cattle in a tropical environment: additive and heterotic effects for milk production, reproduction and calf growth traits

1994 ◽  
Vol 59 (1) ◽  
pp. 21-29 ◽  
Author(s):  
J. E. O. Rege ◽  
G. S. Aboagye ◽  
S. Akah ◽  
B. K. Ahunu
Keyword(s):  
Milk Production ◽  
Growth Traits ◽  
Average Daily Gain ◽  
Reproductive Traits ◽  
Production Traits ◽  
Milk Production Traits ◽  
Weaning Weight ◽  
Calf Growth ◽  
Daily Gain ◽  
Better Than

AbstractCrossbreeding data involving Ghana Shorthorn, Sokoto Gudali and their Jersey F1s and backcrosses collected over a 16-year period were analysed to estimate additive and heterotic effects for milk production, reproduction and calf growth traits. Sokoto Gudali was significantly better than Ghana Shorthorn in all milk production traits. Calving interval and annualized milk production were better in Gudali than in the Shorthorn. The F1s had higher lactation milk yield, milked longer, produced their first calves earlier and had shorter dry periods and calving intervals than their corresponding purebreds. However, genotype was not significant for number of services per conception. Both F1s had higher average daily gain and weaning weight than their corresponding purebreds. Sokoto Gudali backcross (Jersey × F1) was significantly (P < 0·05) better than the F1 in lactation length. However, in Gudali crosses, there was no advantage in increasing the proportion of Jersey genes beyond 0·5 for milk production traits. Additive effects were significantly (at least P < 0·05) lower in the Shorthorn and the Gudali than in Jersey for milk production traits except proportion of butterfat. Heterosis estimates were significant (P < 0·01) for milk production traits for the Shorthorn but not for the Gudali. Heterotic effects were large and significant (at least P < 0·05) in improving annualized milk production in Shorthorn crosses, whilst none of the heterotic effects for reproductive traits was significant. At both 0 and 0·5 levels of Jersey inheritance, the Gudali was superior (P < 0·01) to the Shorthorn in birth weight, weaning weight and pre-weaning average daily gain. Heterotic effects for calf traits were positive and much larger in Gudali crosses than in Shorthorn crosses. In general, backcrosses were, at best, similar to the F1s implying that upgrading these indigenous breeds beyond 0·5 European inheritance may not be desirable.

scholarly journals Selection signature analysis reveals genes underlying sheep milking performance

2019 ◽  
Vol 62 (2) ◽  
pp. 501-508 ◽  
Author(s):  
Zehu Yuan ◽  
Wanhong Li ◽  
Fadi Li ◽  
Xiangpeng Yue
Keyword(s):  
Candidate Genes ◽  
Milk Production ◽  
Food Resource ◽  
Signature Analysis ◽  
Milk Traits ◽  
Selection Signature ◽  
Future Studies ◽  
Sheep Milk ◽  
Milk Performance ◽  
Genetic And Environmental Factors

Abstract. Sheep milk is the most important feed resource for newborn lambs and an important food resource for humans. Sheep milk production and ingredients are influenced by genetic and environmental factors. In this study, we implemented selection signature analysis using Illumina Ovine SNP50 BeadChip data of 78 meat Lacaune and 103 milk Lacaune sheep, which have similar genetic backgrounds, from the Sheep HapMap project to identify candidate genes related to ovine milk traits. Since different methods can detect different variation types and complement each other, we used a haplotype-based method (hapFLK) to implement selection signature analysis. The results revealed six selection signature regions showing signs of being selected (P<0.001): chromosomes 1, 2, 3, 6, 13 and 18. In addition, 38 quantitative trait loci (QTLs) related to sheep milk performance were identified in selection signature regions, which contain 334 candidate genes. Of those, SUCNR1 (succinate receptor 1) and PPARGC1A (PPARG coactivator 1 alpha) may be the most significant genes that affect sheep milking performance, which supply a significant indication for future studies to investigate candidate genes that play an important role in milk production and quality.

scholarly journals Model comparisons and genetic parameter estimates of growth and the Kleiber ratio in Shal sheep

2013 ◽  
Vol 56 (1) ◽  
pp. 264-275 ◽  
Author(s):  
H. Mohammadi ◽  
M. M. Shahrebabak ◽  
H. M. Shahrebabak ◽  
A. Bahrami ◽  
M. Dorostkar
Keyword(s):  
Maternal Effects ◽  
Growth Traits ◽  
Genetic Parameter ◽  
Average Daily Gain ◽  
Genetic Correlations ◽  
Genetic Effects ◽  
Parameter Estimates ◽  
Phenotypic Variance ◽  
Kleiber Ratio ◽  
Lamb Growth

Abstract. Genetic and phenotypic parameters were estimated for lamb growth traits for the Shal sheep using an animal model. Data on lamb growth performance were extracted from available performance records at the Shal sheep Station in Qazvin, Iran. Studied traits were body weights of lambs at birth (BW), at 3 months of age as weaning weight (WW), 6 months weight (6MW), 9 months weight (9MW), yearling weight (YW), average daily gain from birth to weaning (ADG) and Kleiber ratio from birth to weaning (KR). Significant random effects for each trait were determined by fitting additive direct genetic effects, additive maternal effects, covariance between additive direct and additive maternal effects, maternal permanent environmental and maternal temporary environmental (common litter) effects under twelve animal models. Univariate analyses were carried out under the most appropriate model, determined by AIC test. Direct heritability estimates for BW, WW, ADG, KR, 6MW, 9MW and YW were 0.13, 0.19, 0.18, 0.05, 0.16, 0.18 and 0.19, respectively. Maternal additive genetic effects were fitted only for BW and WW; corresponding estimates of 0.12 and 0.10 obtained for maternal heritability of BW and WW, respectively. Maternal permanent environmental effects have low contribution in expression of KR and lead to estimates of 0.06 and 0.06 for maternal permanent environmental variance as a proportion of phenotypic variance (c2) of these traits, respectively. All pre-weaning traits, except KR, were affected by litter effects. The magnitude of ratio of common litter variance to phenotypic variance (l2) was 0.05, 0.12 and 0.14 for BW, WW and ADG, respectively. Direct genetic correlations were positive and ranged from 0.09 for KR-YW to 0.80 for WW-ADG; phenotypic ones ranged from 0.18 for KR-YW to 0.87 for WW-ADG.

Sign in / Sign up

Export Citation Format

Share Document