scholarly journals Analysis of the Oxidative Stress Parameters in Testicular, Hepatic and Renal Tissues Homogenates of Albino Rats after Administration of Imatinib at Peripuberty

2018 ◽  
Vol 27 (4) ◽  
pp. 128-135
Author(s):  
Hafidh Al-Ashoo ◽  
Luma Al-Allaf
Keyword(s):  
Oxidative Stress ◽  
Albino Rats ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

scholarly journals Protective effects of quercetin and vitamin C against nicotine-induced toxicity in the blood of Wistar rats

2016 ◽  
Vol 67 (4) ◽  
pp. 304-310 ◽  
Author(s):  
Milica G. Paunović ◽  
Branka I. Ognjanović ◽  
Miloš M. Matić ◽  
Andraš Š. Štajn ◽  
Zorica S. Saičić
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Liver Enzymes ◽  
Synergistic Effects ◽  
Lipid Peroxide ◽  
Saline Control ◽  
Control Group ◽  
Albino Rats ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

Abstract Nicotine is a potential inducer of oxidative stress, through which it can damage numerous biological molecules. The aim of our study was to investigate the prooxidative effects of nicotine and protective (additive or synergistic) effects of quercetin and vitamin C in the blood of experimental animals, to determine whether the combination of these antioxidants might be beneficial for clinical purposes. Wistar albino rats were receiving intraperitoneal nicotine injection (0.75 mg kg-1 per day) or saline (control group) or nicotine plus quercetin (40 mg kg-1 per day) and vitamin C (100 mg kg-1 per day) for three consecutive days. On day 4, we determined their blood lipid profile, liver enzymes, oxidative stress parameters, and antioxidative system parameters. Compared to untreated control, nicotine significantly increased total cholesterol, LDLcholesterol, triglycerides, liver enzymes (alanine transaminase, aspartate transaminase, and lactate dehydrogenase) and oxidative stress parameters (superoxide anion, hydrogen peroxide, and lipid peroxide) and decreased HDL-cholesterol, glutathione, and superoxide dismutase/catalase activity. Quercetin + vitamin C reversed these values significantly compared to the nicotine alone group. Our results confirm that nicotine has significant prooxidative effects that may disrupt the redox balance and show that the quercetin + vitamin C combination supports antioxidant defence mechanisms with strong haematoprotective activity against nicotine-induced toxicity. In practical terms, this means that a diet rich in vitamin C and quercetin could prevent nicotine-induced toxicity and could also be useful in the supportive care of people exposed to nicotine.

scholarly journals Effect of Monotherapy and Combination Therapy of Pantoprazole and Aprepitant in Gastric Esophageal Reflux Disease in Albino Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Kamleshwar Shukla ◽  
Prince Raj ◽  
Arun Kumar ◽  
Mukesh Kumar ◽  
Gaurav Kaithwas
Keyword(s):  
Oxidative Stress ◽  
Combination Therapy ◽  
Gastric Ph ◽  
Albino Rats ◽  
Total Acidity ◽  
Free Acidity ◽  
Esophageal Reflux ◽  
Sham Control ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

The present study was undertaken to elucidate the effect of pantoprazole and aprepitant on experimental esophagitis in albino rats. Groups of rats, fasted overnight, received normal saline (3 mL/kg, sham control) or toxic control (3 mL/kg) or pantoprazole (30 mg/kg) or aprepitant (10 mg/kg), or their combinations and were subjected to pylorus and forestomach ligation. Animals were sacrificed after 8 h and evaluated for the gastric pH, volume of gastric juices, total acidity, esophagitis index, and free acidity. Esophageal tissues were further subjected to estimations of TBARS, GSH, catalase, and SOD. Treatment with pantoprazole and aprepitant significantly inhibited the gastric secretion, total acidity, and esophagitis index. The treatment also helped to restore the altered levels oxidative stress parameters to normal.

Effects of ferulic acid on oxidative stress parameters in livers and kidneys of Wistar albino rats

2014 ◽  
Vol 229 ◽  
pp. S243-S244
Author(s):  
Merve Bacanli ◽  
Sevtap Aydin ◽  
Gökce Taner ◽  
Hatice Gül Göktas ◽  
Tolga Sahin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ferulic Acid ◽  
Albino Rats ◽  
Oxidative Stress Parameters ◽  
Wistar Albino Rats ◽  
Stress Parameters

Effects of rosmarinic acid on oxidative stress parameters in livers and kidneys of sepsis induced wistar albino rats

2015 ◽  
Vol 238 (2) ◽  
pp. S251
Author(s):  
M. Bacanli ◽  
S. Aydin ◽  
G. Taner ◽  
H.G. Goktas ◽  
T. Sahin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rosmarinic Acid ◽  
Albino Rats ◽  
Oxidative Stress Parameters ◽  
Wistar Albino Rats ◽  
Stress Parameters

Effects of altered thyroid states on oxidative stress parameters in rats

2017 ◽  
Vol 28 (2) ◽  
Author(s):  
Sehkar Oktay ◽  
Lebriz Uslu ◽  
Nesrin Emekli
Keyword(s):  
Oxidative Stress ◽  
Thyroid Hormones ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Ldl Oxidation ◽  
Control Group ◽  
Albino Rats ◽  
Oxidative Stress Parameters ◽  
Altered Thyroid ◽  
Stress Parameters

AbstractBackground:Thyroid hormones are effective on oxidant-antioxidant balance by leading basal metabolic rate. In this study, the effects of altered thyroid states on low density lipoprotein (LDL) oxidation and oxidative stress parameters were investigated in an experimental animal model.Methods:Thirty female Wistar Albino rats were equally divided into 3 groups as follows: control group; hypothyroid group (methimazole (75 mg/100 g was added to diet); hyperthyroid group [Results:A significant increase in lipid parameters was observed in hypothyroid group, whereas these parameters were decreased in hyperthyroid group compared to control group. For ox-LDL levels, a significant increase was observed both in hypothyroid and hyperthyroid groups. In brain, liver and kidney tissues, LPO and SA levels were increased, whereas GSH levels were decreased both in hypothyroid and hyperthyroid groups. The SOD and CAT activities were significantly decreased in hypothyroid group, however, they were increased in hyperthyroid group compared to control group. Both hypothyroid and hyperthyroid conditions modify the oxidant-antioxidant state in serum and tissues.Conclusions:Increased SOD and CAT activities in hyperthyroid group suggest that elevated thyroid hormones can reduce oxidative stress by maintaining antioxidant defense and they might have a protective effect on some tissues against oxidants.

scholarly journals Alteration of oxidative stress parameters in red blood cells of rats after chronic in vivo treatment with cisplatin and selenium

2011 ◽  
Vol 63 (4) ◽  
pp. 991-999 ◽  
Author(s):  
Snezana Markovic ◽  
Jovana Zizic ◽  
Dragana Djacic ◽  
Ana Obradovic ◽  
Milena Curcic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Hematological Parameters ◽  
Albino Rats ◽  
Protective Effects ◽  
Oxidative Stress Parameters ◽  
And Oxidative Stress ◽  
Stress Parameters

In this study we evaluated the possible protective effects of selenium (Se) on hematological and oxidative stress parameters in rats chronically treated with cisplatin (cisPt). Four groups of Wistar albino rats were examined: a control, untreated rats (I), rats treated with Se (II), rats treated with cisPt (III), and rats treated with Se and cisPt (IV). All animals were treated for 5 days successively and killed 24 h after the last treatment. Hematological and oxidative stress parameters were followed in whole blood and red blood cells (RBC). Results showed that the chronic application of Se was followed by a higher number of reticulocytes and platelets, increased lipid peroxidation and GSH content in the RBC. Cisplatin treatment induced depletion of RBC and platelet numbers and an elevation of the superoxide anion, nitrites and glutathione levels. Se and cisPt co-treatment was followed by an elevation of the hematological parameters and the recovery of the glutathione status when compared to the control and cisPt-treated rats.

scholarly journals Biochemical Changes Followed Experimental Respiratory Distress by Benzene Vapours

2019 ◽  
Vol 12 (1) ◽  
pp. 403-409
Author(s):  
Abdel Maksoud H. A. ◽  
Mahfouz M. K. ◽  
Omnia M. A. ◽  
Abdullah M. H ◽  
Eltabey M. E. ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Respiratory Distress ◽  
Biochemical Parameters ◽  
Albino Rats ◽  
Histopathological Changes ◽  
Oxidative Stress Parameters ◽  
And Oxidative Stress ◽  
Alveolar Septa ◽  
Stress Parameters

Monitoring of exposure to chemical matters is seriously needed for evaluating health hazards resulted from its inhalation. The present study was carried out to determine the biochemical, immunological and oxidative stress parameters as well as the possible histological effects of exposure to benzene vapours in male albino rats. Results indicated that; Benzene vapours exposure induced significant increasing in Myeloperoxidase (MPO) enzyme levels. This goes with marked immunologic changes presented by decreases in immunoglobulins; IgA and IgG, along with increases in levels of IgM and IgE. Also, Malondialdehyde (MDA) levels were significantly increased. Meanwhile, reduction in different biochemical parameters including; Superoxide Dismutase (SOD), Catalase (CAT) levels and Glutathione (GSH) content. Lung sections taken showed; Thickening of alveolar septa with chronic inflammation and /or fibrosis, Congested vessels/thick walled vessels and Peri-bronchiolar fibrosis. Hence, the study concluded that; prolonged benzene (BNZ) vapours exposure lead to biochemical, immune disterbance and histopathological changes probably through potentiating oxidative stress and inflammation pathways.

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