scholarly journals Effect of Monotherapy and Combination Therapy of Pantoprazole and Aprepitant in Gastric Esophageal Reflux Disease in Albino Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Kamleshwar Shukla ◽  
Prince Raj ◽  
Arun Kumar ◽  
Mukesh Kumar ◽  
Gaurav Kaithwas
Keyword(s):  
Oxidative Stress ◽  
Combination Therapy ◽  
Gastric Ph ◽  
Albino Rats ◽  
Total Acidity ◽  
Free Acidity ◽  
Esophageal Reflux ◽  
Sham Control ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

The present study was undertaken to elucidate the effect of pantoprazole and aprepitant on experimental esophagitis in albino rats. Groups of rats, fasted overnight, received normal saline (3 mL/kg, sham control) or toxic control (3 mL/kg) or pantoprazole (30 mg/kg) or aprepitant (10 mg/kg), or their combinations and were subjected to pylorus and forestomach ligation. Animals were sacrificed after 8 h and evaluated for the gastric pH, volume of gastric juices, total acidity, esophagitis index, and free acidity. Esophageal tissues were further subjected to estimations of TBARS, GSH, catalase, and SOD. Treatment with pantoprazole and aprepitant significantly inhibited the gastric secretion, total acidity, and esophagitis index. The treatment also helped to restore the altered levels oxidative stress parameters to normal.

scholarly journals Effect ofPerilla frutescensFixed Oil on Experimental Esophagitis in Albino Wistar Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Ekta Arya ◽  
Sudipta Saha ◽  
Shubhini A. Saraf ◽  
Gaurav Kaithwas
Keyword(s):  
Wistar Rats ◽  
Gastric Ph ◽  
Perilla Frutescens ◽  
Albino Rats ◽  
Total Acidity ◽  
Free Acidity ◽  
Alpha Linolenic Acid ◽  
Anticholinergic Activity ◽  
Oxidative Stress Parameters

The present study was undertaken to elucidate the effect ofPerilla frutescensfixed oil on experimental esophagitis in albino rats. A group of rats (n=6), treated with control vehicle (0.9% NaCl in double distilled water, 3 mL/kg, i.p.) andPerilla frutescensfixed oil (100%) (1, 2, and 3 mL/kg, i.p.), or pantoprazole (30 mg/kg, i.p.), were subjected to pylorus and forestomach ligation. Animals were sacrificed after 6 h and evaluated for the gastric pH, volume of gastric juices, total acidity, esophagitis index and free acidity. Esophageal tissues were further subjected to estimations of TBARS, GSH, catalase, and SOD. Treatment with fixed oil significantly inhibited the gastric secretion, total acidity, and esophagitis index. The oil also helped to restore the altered levels of oxidative stress parameters to normal. The present study also makes evident thein vitroantihistaminic and anticholinergic activity of alpha linolenic acid (ALA) (18 : 3,n−3) on isolated rat ileum preparation. The lipoxygenase inhibitory, histamine antagonistic, antisecretory (anticholinergic), and antioxidant activity of the oil was attributed for its efficacy in reflux esophagitis.

Effect of palonosetron (5HT-3 antagonist) and pantoprazole (proton pump inhibitor) against surgical esophagitis induced by forestomach and pylorus ligation in albino rats

2015 ◽  
Vol 35 (1) ◽  
pp. 41-50 ◽  
Author(s):  
A Kumar ◽  
S Gautam ◽  
JK Rawat ◽  
M Singh ◽  
SA Saraf ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Wistar Rats ◽  
Morphological Changes ◽  
Gastric Volume ◽  
Albino Rats ◽  
Total Acidity ◽  
Free Acidity ◽  
Sham Control ◽  
Pylorus Ligation ◽  
Markers Of Oxidative Stress

This study was embarked upon to evaluate the effects of pantoprazole and palonosetron on experimental esophagitis in albino wistar rats. Groups of rats, fasted for 36 h, were subjected to pylorus and forestomach ligation, supervened by treatment with normal saline (3 ml/kg, po, sham control), esophagitis control (3 ml/kg, po), pantoprazole (30 mg/kg, po), palonosetron (0.5 mg/kg, po), and their combination. Animals were sacrificed after 12 h and appraised for the volume of gastric juices, total acidity, free acidity, and esophagitis index. Esophageal tissues were further figured out biochemically for markers of oxidative stress and inflammatory mediators. The combination therapy comparably inhibited the esophagitis index (52.86%), gastric volume (66.04%), free acidity (43.76%), and total acidity (42.60%) in comparison with toxic control. The combination therapy also subsidized the biochemical and inflammatory markers to the purview less than toxic control. The morphological changes were scrutinized by scanning electron microscopy and were observed to demonstrate momentous protection by the amalgamation therapy. Combination therapy with pantoprazole and palonosetron flaunted sententious protection against experimental esophagitis.

scholarly journals Protective effects of quercetin and vitamin C against nicotine-induced toxicity in the blood of Wistar rats

2016 ◽  
Vol 67 (4) ◽  
pp. 304-310 ◽  
Author(s):  
Milica G. Paunović ◽  
Branka I. Ognjanović ◽  
Miloš M. Matić ◽  
Andraš Š. Štajn ◽  
Zorica S. Saičić
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Liver Enzymes ◽  
Synergistic Effects ◽  
Lipid Peroxide ◽  
Saline Control ◽  
Control Group ◽  
Albino Rats ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

Abstract Nicotine is a potential inducer of oxidative stress, through which it can damage numerous biological molecules. The aim of our study was to investigate the prooxidative effects of nicotine and protective (additive or synergistic) effects of quercetin and vitamin C in the blood of experimental animals, to determine whether the combination of these antioxidants might be beneficial for clinical purposes. Wistar albino rats were receiving intraperitoneal nicotine injection (0.75 mg kg-1 per day) or saline (control group) or nicotine plus quercetin (40 mg kg-1 per day) and vitamin C (100 mg kg-1 per day) for three consecutive days. On day 4, we determined their blood lipid profile, liver enzymes, oxidative stress parameters, and antioxidative system parameters. Compared to untreated control, nicotine significantly increased total cholesterol, LDLcholesterol, triglycerides, liver enzymes (alanine transaminase, aspartate transaminase, and lactate dehydrogenase) and oxidative stress parameters (superoxide anion, hydrogen peroxide, and lipid peroxide) and decreased HDL-cholesterol, glutathione, and superoxide dismutase/catalase activity. Quercetin + vitamin C reversed these values significantly compared to the nicotine alone group. Our results confirm that nicotine has significant prooxidative effects that may disrupt the redox balance and show that the quercetin + vitamin C combination supports antioxidant defence mechanisms with strong haematoprotective activity against nicotine-induced toxicity. In practical terms, this means that a diet rich in vitamin C and quercetin could prevent nicotine-induced toxicity and could also be useful in the supportive care of people exposed to nicotine.

Effects of ferulic acid on oxidative stress parameters in livers and kidneys of Wistar albino rats

2014 ◽  
Vol 229 ◽  
pp. S243-S244
Author(s):  
Merve Bacanli ◽  
Sevtap Aydin ◽  
Gökce Taner ◽  
Hatice Gül Göktas ◽  
Tolga Sahin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ferulic Acid ◽  
Albino Rats ◽  
Oxidative Stress Parameters ◽  
Wistar Albino Rats ◽  
Stress Parameters

Effects of rosmarinic acid on oxidative stress parameters in livers and kidneys of sepsis induced wistar albino rats

2015 ◽  
Vol 238 (2) ◽  
pp. S251
Author(s):  
M. Bacanli ◽  
S. Aydin ◽  
G. Taner ◽  
H.G. Goktas ◽  
T. Sahin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rosmarinic Acid ◽  
Albino Rats ◽  
Oxidative Stress Parameters ◽  
Wistar Albino Rats ◽  
Stress Parameters

Effects of altered thyroid states on oxidative stress parameters in rats

2017 ◽  
Vol 28 (2) ◽  
Author(s):  
Sehkar Oktay ◽  
Lebriz Uslu ◽  
Nesrin Emekli
Keyword(s):  
Oxidative Stress ◽  
Thyroid Hormones ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Ldl Oxidation ◽  
Control Group ◽  
Albino Rats ◽  
Oxidative Stress Parameters ◽  
Altered Thyroid ◽  
Stress Parameters

AbstractBackground:Thyroid hormones are effective on oxidant-antioxidant balance by leading basal metabolic rate. In this study, the effects of altered thyroid states on low density lipoprotein (LDL) oxidation and oxidative stress parameters were investigated in an experimental animal model.Methods:Thirty female Wistar Albino rats were equally divided into 3 groups as follows: control group; hypothyroid group (methimazole (75 mg/100 g was added to diet); hyperthyroid group [Results:A significant increase in lipid parameters was observed in hypothyroid group, whereas these parameters were decreased in hyperthyroid group compared to control group. For ox-LDL levels, a significant increase was observed both in hypothyroid and hyperthyroid groups. In brain, liver and kidney tissues, LPO and SA levels were increased, whereas GSH levels were decreased both in hypothyroid and hyperthyroid groups. The SOD and CAT activities were significantly decreased in hypothyroid group, however, they were increased in hyperthyroid group compared to control group. Both hypothyroid and hyperthyroid conditions modify the oxidant-antioxidant state in serum and tissues.Conclusions:Increased SOD and CAT activities in hyperthyroid group suggest that elevated thyroid hormones can reduce oxidative stress by maintaining antioxidant defense and they might have a protective effect on some tissues against oxidants.

Sign in / Sign up

Export Citation Format

Share Document