scholarly journals Effect of Jian-Pi-Zhi-Dong Decoction on the Amino Acid Neurotransmitters in a Rat Model of Tourette Syndrome and Comorbid Anxiety Disorder

2020 ◽  
Vol 11 ◽  
Author(s):  
Wen Zhang ◽  
Wenjing Yu ◽  
Xiaofang Liu ◽  
Qian Wang ◽  
Xue Bai ◽  
...  
Keyword(s):  
Amino Acid ◽  
Anxiety Disorder ◽  
Tourette Syndrome ◽  
Rat Model ◽  
Amino Acid Neurotransmitters ◽  
Comorbid Anxiety

scholarly journals Effects of Jian-Pi-Zhi-Dong Decoction on the Expression of 5-HT and Its Receptor in a Rat Model of Tourette Syndrome and Comorbid Anxiety

2020 ◽  
Vol 26 ◽  
Author(s):  
Dan Wang ◽  
Hui-ling Tian ◽  
Xia Cui ◽  
Qian Wang ◽  
Fan Guo ◽  
...  
Keyword(s):  
Tourette Syndrome ◽  
Rat Model ◽  
Comorbid Anxiety

scholarly journals Antidepressant-Like Effects of Fractions Prepared from Danzhi-Xiaoyao-San Decoction in Rats with Chronic Unpredictable Mild Stress: Effects on Hypothalamic-Pituitary-Adrenal Axis, Arginine Vasopressin, and Neurotransmitters

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Li-Li Wu ◽  
Yan Liu ◽  
Can Yan ◽  
Yi Pan ◽  
Jun-Fang Su ◽  
...  
Keyword(s):  
Amino Acid ◽  
Chronic Stress ◽  
Rat Model ◽  
Soluble Fraction ◽  
Mild Stress ◽  
Stress Model ◽  
Chronic Unpredictable Mild Stress ◽  
Amino Acid Neurotransmitters ◽  
Stress Effects ◽  
Pituitary Adrenal Axis

The aim of the present study was to investigate the antidepressant-like effects of two fractions, including petroleum ether soluble fraction (Fraction A, FA) and water-EtOH soluble fraction (Fraction B, FB) prepared from the Danzhi-xiaoyao-san (DZXYS) by using chronic unpredictable mild stress-induced depressive rat model. The results indicated that DZXYS could ameliorate the depression-like behavior in chronic stress model of rats. The inhibition of hyperactivity of HPA axis and the modulation of monoamine and amino acid neurotransmitters in the hippocampus may be the important mechanisms underlying the action of DZXYS antidepressant-like effect in chronically stressed rats.

scholarly journals Emerging Therapeutics Based on the Amino Acid Neurotransmitter System: An Update on the Pharmaceutical Pipeline for Mood Disorders

2021 ◽  
Vol 5 ◽  
pp. 247054702110204
Author(s):  
Julia Hecking ◽  
Pasha A. Davoudian ◽  
Samuel T. Wilkinson
Keyword(s):  
Amino Acid ◽  
Mood Disorders ◽  
Phase Iii ◽  
Public Health Issue ◽  
Complex Nature ◽  
Novel Therapies ◽  
Amino Acid Neurotransmitters ◽  
Neurotransmitter System ◽  
Phase Iii Clinical Trials ◽  
The World

Mood disorders represent a pressing public health issue and significant source of disability throughout the world. The classical monoamine hypothesis, while useful in developing improved understanding and clinical treatments, has not fully captured the complex nature underlying mood disorders. Despite these shortcomings, the monoamine hypothesis continues to dominate the conceptual framework when approaching mood disorders. However, recent advances in basic and clinical research have led to a greater appreciation for the role that amino acid neurotransmitters play in the pathophysiology of mood disorders and as potential targets for novel therapies. In this article we review progress of compounds that focus on these systems. We cover both glutamate-targeting drugs such as: esketamine, AVP-786, REL-1017, AXS-05, rapastinel (GLYX-13), AV-101, NRX-101; as well as GABA-targeting drugs such as: brexanolone (SAGE-547), ganaxolone, zuranolone (SAGE-217), and PRAX-114. We focus the review on phase-II and phase-III clinical trials and evaluate the extant data and progress of these compounds.

Amino acid neurotransmitters in the central control of blood pressure and in experimental hypertension

1992 ◽  
Vol 10 ◽  
pp. S39 ◽  
Author(s):  
John Chalmers ◽  
Leonard Arnolda ◽  
Vimal Kapoor ◽  
Ida Llewellyn-Smith ◽  
Jane Minson ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Amino Acid ◽  
Experimental Hypertension ◽  
Central Control ◽  
Amino Acid Neurotransmitters
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