scholarly journals Antidepressant-Like Effects of Fractions Prepared from Danzhi-Xiaoyao-San Decoction in Rats with Chronic Unpredictable Mild Stress: Effects on Hypothalamic-Pituitary-Adrenal Axis, Arginine Vasopressin, and Neurotransmitters

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Li-Li Wu ◽  
Yan Liu ◽  
Can Yan ◽  
Yi Pan ◽  
Jun-Fang Su ◽  
...  
Keyword(s):  
Amino Acid ◽  
Chronic Stress ◽  
Rat Model ◽  
Soluble Fraction ◽  
Mild Stress ◽  
Stress Model ◽  
Chronic Unpredictable Mild Stress ◽  
Amino Acid Neurotransmitters ◽  
Stress Effects ◽  
Pituitary Adrenal Axis

The aim of the present study was to investigate the antidepressant-like effects of two fractions, including petroleum ether soluble fraction (Fraction A, FA) and water-EtOH soluble fraction (Fraction B, FB) prepared from the Danzhi-xiaoyao-san (DZXYS) by using chronic unpredictable mild stress-induced depressive rat model. The results indicated that DZXYS could ameliorate the depression-like behavior in chronic stress model of rats. The inhibition of hyperactivity of HPA axis and the modulation of monoamine and amino acid neurotransmitters in the hippocampus may be the important mechanisms underlying the action of DZXYS antidepressant-like effect in chronically stressed rats.

Ketamine abrogates sensorimotor deficits and cytokine dysregulation in a chronic unpredictable mild stress model of depression

2021 ◽  
Author(s):  
Edem Ekpenyong Edem ◽  
Collins-Kevin Chukwudi Anyanwu ◽  
Kate Eberechukwu Nebo ◽  
Elizabeth Toyin Akinluyi ◽  
Adedamola Adediran Fafure ◽  
...  
Keyword(s):  
Mild Stress ◽  
Stress Model ◽  
Chronic Unpredictable Mild Stress ◽  
Sensorimotor Deficits ◽  
Cytokine Dysregulation

Antidepressant effect of helicid in chronic unpredictable mild stress model in rats

2019 ◽  
Vol 67 ◽  
pp. 13-21 ◽  
Author(s):  
Jiucui Tong ◽  
Zhiming Zhou ◽  
Weiwei Qi ◽  
Siyan Jiang ◽  
Bin Yang ◽  
...  
Keyword(s):  
Antidepressant Effect ◽  
Mild Stress ◽  
Stress Model ◽  
Chronic Unpredictable Mild Stress

A metabolomics-based approach for ranking the depressive level in a chronic unpredictable mild stress rat model

RSC Advances ◽  
2016 ◽  
Vol 6 (31) ◽  
pp. 25751-25765 ◽  
Author(s):  
Xinyu Yu ◽  
Shanlei Qiao ◽  
Di Wang ◽  
Jiayong Dai ◽  
Jun Wang ◽  
...  
Keyword(s):  
Animal Model ◽  
Major Depressive Disorder ◽  
Prefrontal Cortex ◽  
Depressive Disorder ◽  
Rat Model ◽  
Untargeted Metabolomics ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Major Depressive ◽  
Metabolomics Study

An untargeted metabolomics study to investigate the metabolome change in plasma, hippocampus and prefrontal cortex (PFC) in an animal model with a major depressive disorder (MDD) had been conducted.

Antidepressant-like effects of Xiaochaihutang in a rat model of chronic unpredictable mild stress

2014 ◽  
Vol 152 (1) ◽  
pp. 217-226 ◽  
Author(s):  
Guang Yue Su ◽  
Jing Yu Yang ◽  
Fang Wang ◽  
Jie Ma ◽  
Kuo Zhang ◽  
...  
Keyword(s):  
Rat Model ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress

scholarly journals Integration of 1H NMR and UPLC-Q-TOF/MS for a Comprehensive Urinary Metabonomics Study on a Rat Model of Depression Induced by Chronic Unpredictable Mild Stress

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e63624 ◽  
Author(s):  
Hong-mei Jia ◽  
Yu-fei Feng ◽  
Yue-tao Liu ◽  
Xing Chang ◽  
Lin Chen ◽  
...  
Keyword(s):  
1H Nmr ◽  
Rat Model ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Tof Ms
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