scholarly journals The Role of Neuroinflammation in Postoperative Cognitive Dysfunction: Moving From Hypothesis to Treatment

2019 ◽  
Vol 9 ◽  
Author(s):  
Seyed A. Safavynia ◽  
Peter A. Goldstein
Keyword(s):  
Cognitive Dysfunction ◽  
Postoperative Cognitive Dysfunction

The role of global cerebral hypoperfusion in the development of postoperative cognitive dysfunction

2008 ◽  
Vol 25 (Supplement 43) ◽  
pp. 23-24
Author(s):  
S. M. Moritz ◽  
A. M Arlt ◽  
V. S. Völkel ◽  
R. L. Rupprecht ◽  
H. J. Hobbhahn
Keyword(s):  
Cognitive Dysfunction ◽  
Postoperative Cognitive Dysfunction ◽  
Cerebral Hypoperfusion

scholarly journals Dysfunction of EAAT3 Enhances LPS-induced Postoperative Cognitive Dysfunction

2021 ◽  
Author(s):  
Xiaoyan Wang ◽  
Yulong Ma ◽  
Aisheng Hou ◽  
Yuxiang Song ◽  
Xin Sui ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Protein Expression ◽  
Learning And Memory ◽  
Cognitive Dysfunction ◽  
Adult Male ◽  
Excitatory Amino Acid ◽  
Postoperative Cognitive Dysfunction ◽  
Male Mice ◽  
Membrane Protein Expression

Abstract Background: Studies have shown that excitatory amino acid transporter 3 (EAAT3) function inhibition is related to several neurodegenerative diseases. Our previous studies also found that the EAAT3 function is intimately linked to learning and memory. In this study, we examined the role of EAAT3 in postoperative cognitive dysfunction (POCD) and explored the potential benefit of riluzole against POCD. Methods: We measured EAAT3 protein expression in hippocampus of male mice at different ages. Next, we established a recombinant adeno-associated viral (rAAV)-mediated shRNA to knockdown EAAT3 expression in the hippocampus of adult male mice. And then the mice received 2μg of lipopolysaccharide (LPS) intracerebroventricular microinjection to construct the POCD model. In addition, we intraperitoneally injected 4mg/kg of riluzole 2 days before LPS microinjection for consecutive 3 days in elderly male mice. Cognitive function was assessed using a Morris water maze 24h after LPS microinjection. Animal behavioral tests, as well as pathological and biochemical assays, were performed to clarify the role of EAAT3 function in POCD and evaluate the effect of activation of EAAT3 function by riluzole. Results: We found that the expression of EAAT3 was significantly decreased in old mice and EAAT3 knockdown in hippocampus aggravated LPS-induced learning and memory deficits in adult male mice. LPS significantly inhibited hippocampal EAAT3 membrane protein expression and GluA1 protein phosphorylation level in adult male mice. Moreover, riluzole pretreatment significantly increased hippocampal EAAT3 membrane protein expression and ameliorated LPS-induced cognitive impairment in old male mice. Conclusions: Our results demonstrated that the dysfunction of EAAT3 is an important risk factor for POCD susceptibility and riluzole may be a promising strategy for prevention and treating of POCD in the elderly people.

scholarly journals Role of interleukin-1β in postoperative cognitive dysfunction

2010 ◽  
Vol 68 (3) ◽  
pp. 360-368 ◽  
Author(s):  
Mario Cibelli ◽  
Antonio Rei Fidalgo ◽  
Niccolò Terrando ◽  
Daqing Ma ◽  
Claudia Monaco ◽  
...  
Keyword(s):  
Cognitive Dysfunction ◽  
Postoperative Cognitive Dysfunction ◽  
Interleukin 1Β

scholarly journals Role of Sox2 in Learning, Memory, and Postoperative Cognitive Dysfunction in Mice

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 727
Author(s):  
Lingli Gui ◽  
Zhen Luo ◽  
Weiran Shan ◽  
Zhiyi Zuo
Keyword(s):  
Learning And Memory ◽  
Cognitive Dysfunction ◽  
Environmental Enrichment ◽  
Postoperative Cognitive Dysfunction ◽  
Sirtuin 1 ◽  
Immunofluorescent Staining ◽  
Control Group ◽  
Barnes Maze ◽  
Clinical Issue

Postoperative cognitive dysfunction (POCD) is a significant clinical issue. Its neuropathogenesis has not been clearly identified and effective interventions for clinical use to reduce POCD have not been established. This study was designed to determine whether environmental enrichment (EE) or cognitive enrichment (CE) reduces POCD and whether sex-determining region Y-box-2 regulated by sirtuin 1, plays a role in the effect. Eighteen-month-old male mice were subjected to right-common-carotid-artery exposure under sevoflurane anesthesia. Some of them stayed in cages with EE or CE after the surgery. Learning and memory of mice were tested by a Barnes maze and fear conditioning, starting 2 weeks after the surgery. Sex-determining region Y-box-2 (Sox2) in the brain was silenced by small hairpin RNA (shRNA). Immunofluorescent staining was used to quantify Sox2-positive cells. Surgery reduced Sox2-positive cells in the hippocampus (64 ± 9 cells vs. 91 ± 9 cells in control group, n = 6, p < 0.001) and impaired learning and memory (time to identify target box one day after training sessions in the Barnes maze test: 132 ± 53 s vs. 79 ± 53 s in control group, n = 10, p = 0.040). EE or CE applied after surgery attenuated this reduction of Sox2 cells and POCD. Surgery reduced sirtuin 1 activity and CE attenuated this reduction. Resveratrol, a sirtuin 1 activator, attenuated POCD and surgery-induced decrease of Sox2-positive cells. Silencing shRNA reduced the Sox2-positive cells in the hippocampus and impaired learning and memory in mice without surgery. These results suggest a role of Sox2 in learning, memory, and POCD. EE and CE attenuated POCD via maintaining Sox2-positive cells in the hippocampus.

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