scholarly journals Critical role of matrix metallopeptidase 9 in postoperative cognitive dysfunction and age-dependent cognitive decline

Oncotarget ◽  
2017 ◽  
Vol 8 (31) ◽  
pp. 51817-51829 ◽  
Author(s):  
Jiangjiang Bi ◽  
Weiran Shan ◽  
Ailin Luo ◽  
Zhiyi Zuo
Keyword(s):  
Cognitive Decline ◽  
Cognitive Dysfunction ◽  
Critical Role ◽  
Postoperative Cognitive Dysfunction ◽  
Age Dependent ◽  
Matrix Metallopeptidase ◽  
Matrix Metallopeptidase 9

Develop a Clinical Prediction Model for Postoperative Cognitive Dysfunction after Major Noncardiac Surgery in Elderly Patients: A Protocol for a Prospective Observational Study

Gerontology ◽  
2021 ◽  
pp. 1-8
Author(s):  
Yang Shen ◽  
Xianchen Li ◽  
Junyan Yao
Keyword(s):  
Observational Study ◽  
Prediction Model ◽  
Cognitive Decline ◽  
Cognitive Dysfunction ◽  
Prospective Observational Study ◽  
Postoperative Cognitive Dysfunction ◽  
Noncardiac Surgery ◽  
Clinical Prediction ◽  
Clinical Prediction Model ◽  
Postoperative Cognitive Decline

Perioperative neurocognitive disorders (PNDs) refer to cognitive decline identified in the preoperative or postoperative period. It has been reported that the incidence of postoperative neurocognitive impairment after noncardiac surgery in patients older than 65 at 1 week was 25.8∼41.4%, and at 3 months 9.9∼12.7%. PNDs will last months or even develop to permanent dementia, leading to prolonged hospital stays, reduced quality of life, and increased mortality within 1 year. Despite the high incidence and poor prognosis of PNDs in the aged population, no effective clinical prediction model has been established to predict postoperative cognitive decline preoperatively. To develop a clinical prediction model for postoperative neurocognitive dysfunction, a prospective observational study (Clinical trial registration number: ChiCTR2000036304) will be performed in the Shanghai General Hospital during January 2021 to October 2022. A sample size of 675 patients aged &#x3e;65 years old, male or female, and scheduled for elective major noncardiac surgery will be recruited. A battery of neuropsychological tests will be used to test the cognitive function of patients at 1 week, 1 month, and 3 months postoperatively. We will evaluate the associations of PNDs with a bunch of candidate predictors including general characteristics of patients, blood biomarkers, indices associated with anesthesia and surgery, retinal nerve-fiber layer thickness, and frailty index to develop the clinical prediction model by using multiple logistic regression analysis and least absolute shrinkage and the selection operator (LASSO) method. The <i>k</i>-fold cross-validation method will be utilized to validate the clinical prediction model. In conclusion, this study was aimed to develop a clinical prediction model for postoperative cognitive dysfunction of old patients. It is anticipated that the knowledge gained from this study will facilitate clinical decision-making for anesthetists and surgeons managing the aged patients undergoing noncardiac surgery.

scholarly journals Age-dependent alteration in muscle regeneration: the critical role of tissue niche

2013 ◽  
Vol 14 (3) ◽  
pp. 273-292 ◽  
Author(s):  
Laura Barberi ◽  
Bianca Maria Scicchitano ◽  
Manuela De Rossi ◽  
Anne Bigot ◽  
Stephanie Duguez ◽  
...  
Keyword(s):  
Muscle Regeneration ◽  
Critical Role ◽  
Age Dependent

The role of global cerebral hypoperfusion in the development of postoperative cognitive dysfunction

2008 ◽  
Vol 25 (Supplement 43) ◽  
pp. 23-24
Author(s):  
S. M. Moritz ◽  
A. M Arlt ◽  
V. S. Völkel ◽  
R. L. Rupprecht ◽  
H. J. Hobbhahn
Keyword(s):  
Cognitive Dysfunction ◽  
Postoperative Cognitive Dysfunction ◽  
Cerebral Hypoperfusion

scholarly journals Dysfunction of EAAT3 Enhances LPS-induced Postoperative Cognitive Dysfunction

2021 ◽  
Author(s):  
Xiaoyan Wang ◽  
Yulong Ma ◽  
Aisheng Hou ◽  
Yuxiang Song ◽  
Xin Sui ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Protein Expression ◽  
Learning And Memory ◽  
Cognitive Dysfunction ◽  
Adult Male ◽  
Excitatory Amino Acid ◽  
Postoperative Cognitive Dysfunction ◽  
Male Mice ◽  
Membrane Protein Expression

Abstract Background: Studies have shown that excitatory amino acid transporter 3 (EAAT3) function inhibition is related to several neurodegenerative diseases. Our previous studies also found that the EAAT3 function is intimately linked to learning and memory. In this study, we examined the role of EAAT3 in postoperative cognitive dysfunction (POCD) and explored the potential benefit of riluzole against POCD. Methods: We measured EAAT3 protein expression in hippocampus of male mice at different ages. Next, we established a recombinant adeno-associated viral (rAAV)-mediated shRNA to knockdown EAAT3 expression in the hippocampus of adult male mice. And then the mice received 2μg of lipopolysaccharide (LPS) intracerebroventricular microinjection to construct the POCD model. In addition, we intraperitoneally injected 4mg/kg of riluzole 2 days before LPS microinjection for consecutive 3 days in elderly male mice. Cognitive function was assessed using a Morris water maze 24h after LPS microinjection. Animal behavioral tests, as well as pathological and biochemical assays, were performed to clarify the role of EAAT3 function in POCD and evaluate the effect of activation of EAAT3 function by riluzole. Results: We found that the expression of EAAT3 was significantly decreased in old mice and EAAT3 knockdown in hippocampus aggravated LPS-induced learning and memory deficits in adult male mice. LPS significantly inhibited hippocampal EAAT3 membrane protein expression and GluA1 protein phosphorylation level in adult male mice. Moreover, riluzole pretreatment significantly increased hippocampal EAAT3 membrane protein expression and ameliorated LPS-induced cognitive impairment in old male mice. Conclusions: Our results demonstrated that the dysfunction of EAAT3 is an important risk factor for POCD susceptibility and riluzole may be a promising strategy for prevention and treating of POCD in the elderly people.

scholarly journals Role of interleukin-1β in postoperative cognitive dysfunction

2010 ◽  
Vol 68 (3) ◽  
pp. 360-368 ◽  
Author(s):  
Mario Cibelli ◽  
Antonio Rei Fidalgo ◽  
Niccolò Terrando ◽  
Daqing Ma ◽  
Claudia Monaco ◽  
...  
Keyword(s):  
Cognitive Dysfunction ◽  
Postoperative Cognitive Dysfunction ◽  
Interleukin 1Β

Case Studies of Postoperative Cognitive Dysfunction in Elderly Patients

2021 ◽  
pp. 1-5
Author(s):  
Kalliopi Megari ◽  
Kalliopi Megari
Keyword(s):  
Quality Of Life ◽  
Elderly Patients ◽  
Cognitive Dysfunction ◽  
Critical Role ◽  
Postoperative Cognitive Dysfunction ◽  
Verbal Working Memory ◽  
Short Term

Background and Objective: Postoperative cognitive dysfunction (POCD) involves decline in several cognitive domains after surgery and is particularly common after cardiac surgery. Given the potential effects of such cognitive dysfunction on quality of life, it is important to study it in multiple populations in order to limit its occurrence. Recent advances in surgical technology may assist in achieving this goal. Methods: We present the long-term neuropsychological outcome of two elderly patients, one of whom had off pump heart surgery and the other oncological surgery. We administered a series of neuropsychological tests assessing attention, complex scanning, verbal working memory, executive functioning, short-term and long-term memory, and visuospatial perception before surgery, prior to discharge, at 3-month follow-up and 6 years after surgery. We compared the performance of these two patients to normative datasets. Results: Despite equivalent levels of pre-surgery performance between the two patients, the oncology patient exceeded his preoperative neurocognitive levels, suggesting less postoperative cognitive dysfunction in the heart patient overall, on all neuropsychological domains at 6-year follow-up, except short-term retention. In contrast, the heart patient showed no improvement, and, instead, showed some cognitive decline which remained consistent over time. Conclusion: Our findings highlight the critical role of the type of surgery utilized in the development of POCD and have implications for clinical management and patients’ quality of life in the very long term.

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