scholarly journals Formal Semantics in the Neurology Clinic: Atypical Understanding of Aspectual Coercion in ALS Patients

2016 ◽  
Vol 7 ◽  
Author(s):  
Giosuè Baggio ◽  
Giulia Granello ◽  
Lorenzo Verriello ◽  
Roberto Eleopra
Keyword(s):  
Formal Semantics ◽  
Aspectual Coercion ◽  
Neurology Clinic ◽  
Als Patients

Otolaryngologic presentations of amyotrophic lateral sclerosis

2005 ◽  
Vol 132 (3) ◽  
pp. 500-504 ◽  
Author(s):  
Anton Chen ◽  
C. Gaelyn Garrett
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Study Design ◽  
Retrospective Review ◽  
Neuromuscular Disease ◽  
Vocal Fold ◽  
Neurology Clinic ◽  
Bulbar Symptoms ◽  
Neuromuscular Abnormalities ◽  
Als Patients ◽  
Lateral Sclerosis

OBJECTIVES/HYPOTHESIS: To determine the incidence of voice disturbance as a presenting symptom of amyotrophic lateral sclerosis (ALS) and describe laryngologic features of ALS. STUDY DESIGN: Retrospective review. METHODS: Records of patients with voice disturbance at a voice center and ALS patients at a neurology clinic were reviewed from January 1998 to March 2003. RESULTS: 15 of 1759 patients with voice disturbance were later diagnosed with ALS. Of 220 ALS patients presenting to neurology clinic, 44 had bulbar symptoms and 19 had initially presented to an otolaryngologist. Dysarthria, dysphagia, tongue fasciculation, and incomplete vocal fold closure were common findings. Neuromuscular disease was missed in 8 of 19 ALS patients seen by an otolaryngologist. CONCLUSIONS: Although otolaryngologists rarely encounter undiagnosed ALS patients, a significant portion of bulbar ALS patients are initially evaluated by otolaryngologists. SIGNIFICANCE: Vigilance for neuromuscular abnormalities on otolaryngologic exam is important in patients who present with dysarthria, dysphonia, or dysphagia. EBM rating: C.

Denial and depression in ALS patients and their caregivers: A social-interactive perspective on illness coping

2004 ◽  
Author(s):  
Steven E. Mock ◽  
Elaine Wethington ◽  
Ishtar Gabriel ◽  
John Turnbull
Keyword(s):  
Als Patients

The wish to hasten death among ALS patients in a palliative care program

2007 ◽  
Vol 34 (S 2) ◽  
Author(s):  
R Jox ◽  
S Haarmann-Doetkotte ◽  
M Wasner ◽  
GD Borasio
Keyword(s):  
Palliative Care ◽  
Care Program ◽  
Palliative Care Program ◽  
Wish To Hasten Death ◽  
Als Patients

Immunosuppressive Functions of M2 Macrophages Derived from iPSCs of ALS Patients

2020 ◽  
Author(s):  
Weihua Zhao ◽  
David R. Beers ◽  
Jason R. Thonhoff ◽  
Aaron D. Thome ◽  
Alireza Faridar ◽  
...  
Keyword(s):  
M2 Macrophages ◽  
Als Patients

Riluzole Exhibits No Therapeutic Efficacy on a Transgenic Rat model of Amyotrophic Lateral Sclerosis

2020 ◽  
Vol 17 (3) ◽  
pp. 275-285 ◽  
Author(s):  
Si Chen ◽  
Qiao Liao ◽  
Ke Lu ◽  
Jinxia Zhou ◽  
Cao Huang ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Motor Neurons ◽  
Rat Model ◽  
Microglial Activation ◽  
Transgenic Rat ◽  
Intragastric Administration ◽  
Behavioral Deficits ◽  
Als Patients ◽  
Lateral Sclerosis ◽  
Transgenic Rat Model

Background: Amyotrophic lateral sclerosis (ALS) is a neurological disorder clinically characterized by motor system dysfunction, with intraneuronal accumulation of the TAR DNAbinding protein 43 (TDP-43) being a pathological hallmark. Riluzole is a primarily prescribed medicine for ALS patients, while its therapeutical efficacy appears limited. TDP-43 transgenic mice are existing animal models for mechanistic/translational research into ALS. Methods: We developed a transgenic rat model of ALS expressing a mutant human TDP-43 transgene (TDP-43M337V) and evaluated the therapeutic effect of Riluzole on this model. Relative to control, rats with TDP-43M337V expression promoted by the neurofilament heavy subunit (NEF) gene or specifically in motor neurons promoted by the choline acetyltransferase (ChAT) gene showed progressive worsening of mobility and grip strength, along with loss of motor neurons, microglial activation, and intraneuronal accumulation of TDP-43 and ubiquitin aggregations in the spinal cord. Results: Compared to vehicle control, intragastric administration of Riluzole (30 mg/kg/d) did not mitigate the behavioral deficits nor alter the neuropathologies in the transgenics. Conclusion: These findings indicate that transgenic rats recapitulate the basic neurological and neuropathological characteristics of human ALS, while Riluzole treatment can not halt the development of the behavioral and histopathological phenotypes in this new transgenic rodent model of ALS.

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