scholarly journals A Mixed Comparisons of Different Intensities and Types of Physical Exercise in Patients With Diseases Related to Oxidative Stress: A Systematic Review and Network Meta-Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhenghui Lu ◽  
Yining Xu ◽  
Yang Song ◽  
István Bíró ◽  
Yaodong Gu
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Exercise Training ◽  
Physical Exercise ◽  
Tai Chi ◽  
Aerobic Training ◽  
Meta Analysis ◽  
Moderate Intensity ◽  
Cochrane Library ◽  
Antioxidant Systems

The balance of oxidative and antioxidant systems is of great importance to the human body. Physical exercise, as one of the ways to improve physical health, seems to modulate this balance. However, different intensities and types of physical exercise have other effects on the treatment of unhealthy people. To understand the impact of exercise training on the oxidative and antioxidant systems of adults with oxidative stress-related disorders, a network meta-analysis was used to compare the mixed effects of different intensities and types of exercise training. This systematic review included all eligible RCTs from PubMed, Medline, Cochrane Library, and CINAHL. Eleven of the studies met the inclusion criteria (at study completion, n = 666 participants). Seven studies reported that the level of MDA decreased significantly after exercise (p < 0.05), and 3 studies reported that the level of SOD increased significantly after exercise (p < 0.05). In conclusion, long-term high-intensity aerobic training and Tai Chi or Yoga can effectively improve oxidative stress in unhealthy people. In addition, different types of diseases on the effect of exercise intervention seems to be other, diabetes and chronic kidney patients using moderate-intensity aerobic training or Tai chi and Yoga effect are better; Moderate-intensity aerobic training had a better impact on OS improvement in patients with irritable bowel syndrome and severe depression. However, more research is needed to determine the effects of different levels and types of physical activity on oxidative stress in unhealthy populations.Systematic Review Registration: PROSPERO identifier: CRD42021242025. https://www.crd.york.ac.uk/prospero/.

scholarly journals Effect of Tai Chi on Markers of Oxidative Stress: Systematic Review and Meta-Analysis

2021 ◽  
Vol 18 (7) ◽  
pp. 3458
Author(s):  
Juana Rosado-Pérez ◽  
Osvaldo D. Castelán-Martínez ◽  
Abril J. Mújica-Calderón ◽  
Martha A. Sánchez-Rodríguez ◽  
Víctor Manuel Mendoza-Núñez
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Superoxide Dismutase ◽  
Sedentary Behavior ◽  
Tai Chi ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Stress Markers ◽  
Markers Of Oxidative Stress ◽  
Mean Differences

Background: This study aimed to synthesize the evidence of the effect of practicing Tai Chi on oxidative stress markers (OxSM). Methods: This systematic review and meta-analysis was conducting using the MEDLINE, Cochrane Library, ScienceDirect, Scopus, Epistemonikos, Lilacs, and Ovid databases to identify randomized (RCT) and non-randomized (NRCT) clinical trials that evaluated the Tai Chi effect on OxSM compared to sedentary behavior, walking or yoga. Pooled mean differences (MDs) with 95% confidence intervals (95%CI) were estimated using the inverse variance method to determine the effect of Tai Chi on OxSM. PROSPERO register: CRD42019138362. Results: Five RCT and five NRCT were included. Compared to sedentary behavior, regular Tai Chi practice increases the levels of the enzymes superoxide dismutase (MD = 34.97 U/mL, (95%CI, 9.45 to 60.48), 344 participants) and catalase (MD = 15.63 U/mL, (95%CI, 4.05 to 27.22), 110 participants), as well as reducing the levels of lipoperoxides (MD = −0.02 µmol/L, (95%CI, −0.04 to −0.00), 234 participants). For comparisons with walking or yoga, only one study per activity was identified comparing the effect on OxSM. Conclusions: Regular Tai Chi practice increases the levels of superoxide dismutase and catalase, as well as reducing the levels of lipoperoxides. More studies are necessary to determine the effect of Tai Chi on OxSM when compared to other physical activities.

Therapeutic effect of resveratrol supplementation on oxidative stress: a systematic review and meta-analysis of randomised controlled trials

2019 ◽  
Vol 96 (1134) ◽  
pp. 197-205 ◽  
Author(s):  
Mehdi Koushki ◽  
Mostafa Lakzaei ◽  
Hadi Khodabandehloo ◽  
Hossein Hosseini ◽  
Reza Meshkani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Publication Bias ◽  
Randomised Controlled Trials ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Controlled Trials ◽  
Oxidative Markers ◽  
Markers Of Oxidative Stress ◽  
Randomised Controlled

BackgroundResveratrol is a naturally occurring polyphenol compound mainly found in grapes and red wine. The evidence has suggested that resveratrol has an antioxidant effect. However, the results are inconsistent and inconclusive. Thus, we conducted a systematic review and meta-analysis to evaluate the effect of resveratrol supplementation on markers of oxidative stress.MethodsWe searched PubMed, ISI Web of Science, EMBASE, Scopus and the Cochrane library up to December 2018 to identify randomised controlled trials (RCTs) assessing resveratrol supplementation effects on oxidative markers. Heterogeneity, publication bias, risk of bias and subgroup analysis were analysed. This meta-analysis was conducted in accordance with the guidelines of the Preferred ReportingItems for Systematic Reviews and Meta-Analysis (PRISMA).ResultsMeta-analysis of data from 12 RCTs did not support significant effect of resveratrol supplementation on circulating levels of superoxide dismutase (SOD) (standardized mean difference (SMD) (1.12), (95% CI −0.91 to 3.1), p=0.28), catalase (CAT) (SMD (−0.07), (95% CI −1.4 to 1.3), p=0.92) and glutathione peroxidase (GPx) (SMD (−0.76), (95% CI −2.56 to 1.04), p=0.40). Although, resveratrol supplementation increased significantly circulating total antioxidant capacity (TAC) concentrations (SMD (0.52), (95% CI −0.02 to 1.07), p=0.05). Severe heterogeneity was observed between studies, and no obvious publication bias was observed in included RCTs.ConclusionCollectively, our findings of available RCTs did no show any benefit of resveratrol supplementation on SOD, CAT and GPx except for TAC. Well-designed RCTs are necessary to confirm these results.

scholarly journals P1269EXERCISE TRAINING FOR IMPROVING SLEEP QUALITY IN PATIENTS WITH END-STAGE KIDNEY DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Jueyao Liang ◽  
Xindong Qin ◽  
Guobin Su ◽  
La Zhang ◽  
Huanyu Liu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Kidney Disease ◽  
Exercise Training ◽  
Sleep Quality ◽  
Aerobic Training ◽  
Meta Analysis ◽  
Regular Exercise ◽  
End Stage

Abstract Background and Aims Sleep disorders are commonly experienced by patients with end-stage kidney disease (ESKD) which influence the quality of life severely and may cause high risk of cardiovascular events. People with ESKD may constrain the use of neuroleptic medications which can lead to dependence if used in the longer-term. As non-pharmacological intervention, exercise training was suggested as based therapy to improve the quality of life. We conducted a systematic review to assess the efficacy of exercise training for improving sleep quality in dialysis patients with ESKD. Method Randomised controlled trials (RCTs) that evaluated the effects of regular exercise training on sleep quality in patients with ESKD were included. Searching was conducted in CENTRAL, EMBASE, PUBMED, CINAHL, WEB OF SCIENCE, and 3 Chinese databases (CBM, CNKI, WANFANG), date from inception to May 2019. Risk of bias was assessed. The quality and strength of evidence were evaluated by GRADE framework. Study selection, data extraction and methodological quality assessment were performed independently by two researchers. Results were reported as mean differences (MD) for continuous outcomes, with 95% confidence intervals (CI). This systematic review was registered in the PROSPERO (CRD42019141630). Results Twelve RCTs were included, which involving 753 participants. Methodological quality of studies and strength of evidence were assessed from low to moderate. Eleven trials included patients who receiving regular hemodialysis (HD) and one trial included patients that receiving either regular HD or continuous ambulatory peritoneal dialysis (CAPD). The major type of exercise was aerobic training during hemodialysis session (7 RCTs), followed by intradialytic resistance exercise, intradialytic mixed training, and interdialytic aerobic exercise. Most studies set exercise 3 times per week with moderate intensity, lasting 20∼60 minutes per session, and treatment duration for 2∼6 months. The Pittsburgh Sleep Quality Index (PSQI) questionnaire, Kidney Disease Quality of Life (KDQoL-SF) questionnaire, University of Massachusetts Weekly Sleep Questionnaire (UMass WSQ), visual analogue scale (VAS), and sleep fragmentation index (SFI) based on patient-reported outcomes were measured for testing sleep quality. By measuring with PSQI questionnaire (scale 0-21, lower is better), the sleep quality was improved with regular exercise comparing with usual care (5 RCTs, 296 participants, MD -4.92, 95%CI -6.54 to -3.30, I2=88%, moderate certainty evidence). The result was similar with KDQoL-SF questionnaire (4 items assessing sleep quality, higher is better) (3 RCTs, 328 participants, MD 8.75, 95%CI 2.06 to 15.43, I2=54%, low certainty evidence). However, there was no significant different in sleep diary by measuring with UMass WSQ (2 RCTs, 46 participants, MD -0.48, 95%CI -4.05 to 3.09, I2=59%, low certainty evidence). There was only one study measured with VAS and SFI, so we didn’t analyze it into meta-analysis. Conclusion Regular exercise appeared to be beneficial to improve sleep quality in patients with dialysis, especially intradialytic aerobic training. Given the growing challenge of pharmacological dependence, there is necessary to design high quality RCTs for non-pharmacological interventions such as exercise training.

The Effects of Resveratrol on Oxidative Stress Markers: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

2020 ◽  
Vol 20 (5) ◽  
pp. 718-727 ◽  
Author(s):  
Mahsa Omidian ◽  
Mina Abdolahi ◽  
Elnaz Daneshzad ◽  
Mohsen Sedighiyan ◽  
Mohadeseh Aghasi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Serum Levels ◽  
Oxidative Stress Marker ◽  
Cochrane Library ◽  
Oxidative Stress Markers ◽  
Stress Markers

Objective: Recent trial studies have found that resveratrol supplementation beneficially reduces oxidative stress marker, but, there is no definitive consensus on this context. The present systematic review and meta-analysis aimed to investigate the effect of resveratrol supplementation on oxidative stress parameters. Methods: We searched databases of Pubmed, Scopus and Cochrane Library up to December 2018 with no language restriction. Studies were reviewed according to preferred reporting items for systematic reviews and meta-analyses (PRISMA) and Cochrane handbook. To compare the effects of resveratrol with placebo, weighted mean difference (WMD) with 95% confidence intervals (CI) were pooled based on the random-effects model. Results: Among sixteen clinical trials, we found that resveratrol supplementation increased GPx serum levels significantly (WMD: 18.61; 95% CI: 8.70 to 28.52; P<0.001) but had no significant effect on SOD concentrations (WMD: 1.01; 95% CI: -0.72 to 2.74; P= 0.25), MDA serum levels (WMD: -1.43; 95% CI: -3.46 to 0.61; P = 0.17) and TAC (WMD: -0.09; 95% CI: -0.29 to 0.11; P = 0.36) compared to placebo. Finally, we observed that resveratrol supplementation may not have a clinically significant effect on oxidative stress. Conclusion: However, the number of human trials is limited in this context, and further large prospective clinical trials are needed to confirm the effect of resveratrol supplement on oxidative stress markers.

scholarly journals Aerobic Exercise-Induced Changes in Cardiorespiratory Fitness in Breast Cancer Patients Receiving Chemotherapy: A Systematic Review and Meta-Analysis

Cancers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2240
Author(s):  
Guilherme Maginador ◽  
Manoel E. Lixandrão ◽  
Henrique I. Bortolozo ◽  
Felipe C. Vechin ◽  
Luís O. Sarian ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Aerobic Exercise ◽  
Usual Care ◽  
Cardiorespiratory Fitness ◽  
Aerobic Training ◽  
Meta Analysis ◽  
Moderate Intensity ◽  
Training Intensity ◽  
Vigorous Intensity

While performing aerobic exercise during chemotherapy has been proven feasible and safe, the efficacy of aerobic training on cardiorespiratory fitness (CRF) in women with breast cancer undergoing chemotherapy has not yet been systematically assessed. Therefore, the objective of this work was to determine (a) the efficacy of aerobic training to improve CRF; (b) the role of aerobic training intensity (moderate or vigorous) on CRF response; (c) the effect of the aerobic training mode (continuous or interval) on changes in CRF in women with breast cancer (BC) receiving chemotherapy. A systematic review and meta-analysis were conducted as per PRISMA guidelines, and randomized controlled trials comparing usual care (UC) and aerobic training in women with BC undergoing chemotherapy were eligible. The results suggest that increases in CRF are favored by (a) aerobic training when compared to usual care; (b) vigorous-intensity aerobic exercise (64–90% of maximal oxygen uptake, VO2max) when compared to moderate-intensity aerobic exercise (46–63% of VO2max); and (c) both continuous and interval aerobic training are effective at increasing the VO2max. Aerobic training improves CRF in women with BC undergoing chemotherapy. Notably, training intensity significantly impacts the VO2max response. Where appropriate, vigorous intensity aerobic training should be considered for women with BC receiving chemotherapy.

scholarly journals Physical Exercise and Health-Related Quality of Life in Office Workers: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 18 (7) ◽  
pp. 3791
Author(s):  
Thi Mai Nguyen ◽  
Van Huy Nguyen ◽  
Jin Hee Kim
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Physical Exercise ◽  
Meta Analysis ◽  
Office Workers ◽  
Cochrane Library ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Office workers are at high risk for many chronic diseases, lowering their health-related quality of life (HRQOL). This systematic review and meta-analysis aimed to summarize the effects of physical exercise on HRQOL in office workers with and without health problems using data obtained from randomized controlled trials (RCTs), quasi-experimental, and observational studies. We searched PubMed, Web of Science, Scopus, Cochrane Library, and several grey literature databases, and identified 26 relevant studies for the synthesis. Overall, physical exercise significantly improved general (standardized mean difference (SMD) = 1.05; 95% confidence interval (CI): 0.66 to 1.44) and mental (SMD = 0.42; 95% CI: 0.19 to 0.66) HRQOL in office workers. Compared with healthy office workers, unhealthy office workers experienced greater improvements in general (unhealthy, SMD = 2.76; 95% CI: 1.63 to 3.89; healthy, SMD = 0.23; 95% CI: −0.09 to 0.56) and physical (unhealthy, SMD = 0.38; 95% CI: 0.17 to 0.58; healthy, SMD = −0.20; 95% CI: −0.51 to 0.11) HRQOL. Unsupervised physical exercise significantly improved general and mental HRQOL, while directly supervised physical exercise significantly improved only general HRQOL. Although physical exercise, especially unsupervised physical exercise, should be encouraged to improve HRQOL in office workers, detailed recommendations could not be made because of the diverse exercise types with different intensities. Therefore, further studies are needed to determine the optimal exercise for office workers with different health conditions.

scholarly journals Exercise training modalities for heart transplant recipients: a systematic review and network meta-analysis protocol

BMJ Open ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. e044975
Author(s):  
Juliana Beust de Lima ◽  
Douglas dos Santos Soares ◽  
Filipe Ferrari ◽  
Nelson Carvas Junior ◽  
Gabriel Carvalho ◽  
...  
Keyword(s):  
Systematic Review ◽  
Exercise Training ◽  
Heart Transplant ◽  
Meta Analysis ◽  
Walking Distance ◽  
Cochrane Library ◽  
Control Group ◽  
Subjective Perception ◽  
Training Modality ◽  
Training Modalities

IntroductionHeart transplantation is the gold standard treatment for selected patients with end-stage heart failure. Although this procedure can improve quality and prolong life expectancy, several of these patients persist with decreased exercise tolerance. Evidence suggests that exercise training can bring multifactorial benefits to heart transplant (HTx) recipients. However, it is unclear that exercise modality should be preferred. Therefore, the aim of this systematic review and network meta-analysis is to compare the efficacy and safety of different training modalities in HTx recipients.Methods and analysisWe will perform a comprehensive literature search in PubMed/MEDLINE, Embase, The Cochrane Library, CINAHL, Scopus, SportDISCUS, Web of Science Core Collection and PEDro from inception until November 2020. Two registries (ClinicalTrials.gov and REBEC) will also be searched for potential results in unpublished studies. There will be no restriction on language, date of publication, publication status or sample size. We will include randomised controlled trials enrolling adult HTx recipients with the presence of at least one exercise training group, which might be compared with another training modality and/or a non-exercise control group for a minimum of 4 weeks of intervention. The primary outcomes will be peak oxygen consumption and occurrence of adverse events. As secondary outcomes, the interaction between pulmonary ventilation, pulmonary perfusion and cardiac output, oxygen uptake efficiency slope, heart rate response, oxygen pulse, peak blood pressure and peak subjective perception of effort. In addition, we will evaluate the 6 min walking distance, health-related quality of life, endothelial function, muscle strength, body fat percentage and lean mass. Risk of bias will be assessed using the Cochrane RoB V.2.0 tool, and we plan to use the Confidence in Network Meta-Analysis tool to assess confidence in the results. All materials (raw data, processed data, statistical code and outputs) will be shared in a public repository.Ethics and disseminationGiven the nature of this study, no ethical approval will be required. We believe that the findings of this study may show which is the most efficacious and safe physical training modality for HTx recipients. The completed systematic review and network meta-analysis will be submitted to a peer-reviewed journal.PROSPERO registration numberCRD42020191192.

scholarly journals Effects of different exercise training modes on muscle strength and physical performance in older people with sarcopenia: a systematic review and meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Linqian Lu ◽  
Lin Mao ◽  
Yuwei Feng ◽  
Barbara E. Ainsworth ◽  
Yu Liu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Resistance Training ◽  
Muscle Strength ◽  
Exercise Training ◽  
Older People ◽  
Physical Performance ◽  
Meta Analysis ◽  
Whole Body ◽  
Cochrane Library ◽  
Randomized Controlled

Abstract Objective We conducted a systematic review and meta-analysis to clarify the effects of different exercise modes (resistance training [RT], whole body vibration training [WBVT], and mixed training [MT, resistance training combined with other exercises such as balance, endurance and aerobic training]) on muscle strength (knee extension strength [KES]) and physical performance (Timed Up and Go [TUG], gait speed [GS] and the Chair Stand [CS]) in older people with sarcopenia. Method All studies published from January 2010 to March 2021 on the effects of exercise training in older people with sarcopenia were retrieved from 6 electronic databases: Pubmed, Cochrane Library, Embase, Web of Science, the China National Knowledge Infrastructure (CNKI), and Wanfang Database. Two researchers independently extracted and evaluated studies that met inclusion and exclusion criteria. Pooled analyses for pre- and post- outcome measurements were performed using Review Manager 5.4 with standardized mean differences (SMDs) and fixed-effect models. Result Twenty-six studies (25 randomized controlled trails [RCTs] and one non-randomized controlled trail) were included in this study with 1191 older people with sarcopenia (mean age 60.6 ± 2.3 to 89.5 ± 4.4). Compared with a control group, RT and MT significantly improved KES (RT, SMD = 1.36, 95% confidence intervals [95% CI]: 0.71 to 2.02, p < 0.0001, I2 = 72%; MT, SMD = 0.62, 95% CI: 0.29 to 0.95, p = 0.0002, I2 = 56%) and GS (RT, SMD = 2.01, 95% CI: 1.04 to 2.97, p < 0.0001, I2 = 84%; MT, SMD = 0.69, 95% CI: 0.29 to 1.09, p = 0.008, I2 = 81%). WBVT showed no changes in KES (SMD = 0.65, 95% CI: − 0.02 to 1.31, p = 0.06, I2 = 80%) or GS (SMD = 0.12, 95% CI: − 0.15 to 0.39, p = 0.38, I2 = 0%). TUG times were significantly improved with all exercise training modes (SMD = -0.66, 95% CI: − 0.94 to − 0.38, p < 0.00001, I2 = 60%). There were no changes in CS times with any of the exercise training modes (SMD = 0.11, 95% CI: − 0.36 to 0.57, p = 0.65, I2 = 87%). Conclusions In older people with sarcopenia, KES and GS can be improved by RT and MT, but not by WBVT. All three training modes improved TUG times, but not improved CS times.

scholarly journals Clinical Evidence of Tai Chi Exercise Prescriptions: A Systematic Review

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Jiafu Huang ◽  
Dandan Wang ◽  
Jinghao Wang
Keyword(s):  
Systematic Review ◽  
Tai Chi ◽  
Clinical Evidence ◽  
Metabolic Diseases ◽  
Exercise Prescription ◽  
Connective Tissue Diseases ◽  
Moderate Intensity ◽  
Cochrane Library ◽  
Circulatory System Diseases ◽  
Tai Chi Exercise

Objectives. This systematic review aims to summarize the existing literature on Tai Chi randomized controlled trials (RCTs) and recommend Tai Chi exercise prescriptions for different diseases and populations. Methods. A systematic search for Tai Chi RCTs was conducted in five electronic databases (PubMed, Cochrane Library, EMBASE, EBSCO, and Web of Science) from their inception to December 2019. SPSS 20.0 software and Microsoft Excel 2019 were used to analyze the data, and the risk of bias tool in the RevMan 5.3.5 software was used to evaluate the methodological quality of RCTs. Results. A total of 139 articles were identified, including diseased populations (95, 68.3%) and healthy populations (44, 31.7%). The diseased populations included the following 10 disease types: musculoskeletal system or connective tissue diseases (34.7%), circulatory system diseases (23.2%), mental and behavioral disorders (12.6%), nervous system diseases (11.6%), respiratory system diseases (6.3%), endocrine, nutritional or metabolic diseases (5.3%), neoplasms (3.2%), injury, poisoning and certain other consequences of external causes (1.1%), genitourinary system diseases (1.1%), and diseases of the eye and adnexa (1.1%). Tai Chi exercise prescription was generally classified as moderate intensity. The most commonly applied Tai Chi style was Yang style (92, 66.2%), and the most frequently specified Tai Chi form was simplified 24-form Tai Chi (43, 30.9%). 12 weeks and 24 weeks, 2-3 times a week, and 60 min each time was the most commonly used cycle, frequency, and time of exercise in Tai Chi exercise prescriptions. Conclusions. We recommend the more commonly used Tai Chi exercise prescriptions for different diseases and populations based on clinical evidence of Tai Chi. Further clinical research on Tai Chi should be combined with principles of exercise prescription to conduct large-sample epidemiological studies and long-term prospective follow-up studies to provide more substantive clinical evidence for Tai Chi exercise prescriptions.

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