scholarly journals Peripheral BDNF Response to Physical and Cognitive Exercise and Its Association With Cardiorespiratory Fitness in Healthy Older Adults

2020 ◽  
Vol 11 ◽  
Author(s):  
Olga Tarassova ◽  
Maria M. Ekblom ◽  
Marcus Moberg ◽  
Martin Lövdén ◽  
Jonna Nilsson
Keyword(s):  
Older Adults ◽  
Cardiorespiratory Fitness ◽  
Healthy Older Adults ◽  
Cognitive Exercise

scholarly journals Cardiorespiratory fitness, physical activity and pulse pressure as predictors of learning in a multicomponent intervention in healthy older adults

2021 ◽  
Author(s):  
Jonna Nilsson ◽  
Maria Ekblom ◽  
Olga Tarassova ◽  
Martin Lövdén
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Working Memory ◽  
Cardiorespiratory Fitness ◽  
Pulse Pressure ◽  
Intervention Period ◽  
Healthy Older Adults ◽  
Multicomponent Intervention ◽  
Predictive Role

This project concerns new analyses based on pre-existing data from a randomized controlled multicomponent intervention study combining physical exercise and cognitive training in healthy older adults. The project tests the predictive role of cardiorespiratory fitness, physical activity and pulse pressure for learning in a working memory training context, in combination with physical exercise and in isolation. Specifically, two learning outcomes are considered: change in trained working memory tasks from before to after the intervention period (pre-post change) and day-by-day change in n-back performance during the intervention period (up to 32 timepoints). The results did not support a predictive role of cardiorespiratory fitness, physical activity or pulse pressure for learning in this particular study context. Please note that this document is intended solely as a report of the results pertaining to the registered hypotheses on Open Science Framework (https://osf.io/h5npm), simply to ensure transparency also of the null findings. As such, this document is not intended for formal peer-review or publication. If you are interested in the results, please do not hesitate to contact the author of this document ([email protected]).

The Relationship between Cardiorespiratory Fitness and Montreal Cognitive Assessment Scores in Older Adults

Gerontology ◽  
2018 ◽  
Vol 64 (5) ◽  
pp. 440-445 ◽  
Author(s):  
Stephen W. Farrell ◽  
Aidin R. Abramowitz ◽  
Benjamin L. Willis ◽  
Carolyn E. Barlow ◽  
Myron Weiner ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Cardiorespiratory Fitness ◽  
Cognitive Assessment ◽  
Montreal Cognitive Assessment ◽  
Categorical Variable ◽  
Healthy Older Adults ◽  
High Level ◽  
The Relationship

Background: Relatively little is known regarding the association between objective measures of physical function such as cardiorespiratory fitness (CRF) and cognitive function tests in healthy older adults. Objective: To evaluate the relationship between CRF and cognitive function in adults aged 55 and older. Methods: Between 2008 and 2017, 4,931 men and women underwent a comprehensive preventive physical exam at the Cooper Clinic in Dallas, Texas. CRF was determined by duration of a maximal treadmill exercise test. Cognitive function was evaluated with the Montreal Cognitive Assessment (MoCA). In a multivariate model, adjusted odds ratios with 95% confidence intervals for MoCA scores < 26 (i.e., cognitive impairment) were determined by using CRF as both a continuous and a categorical variable. Results: The mean age of the sample was 61.0 ± 6.0 years; mean maximal MET values were 10.0 ± 2.2. Mean MoCA scores were 26.9 ± 2.2; 23.4% of the sample had MoCA scores indicative of cognitive impairment. The odds ratio for cognitive impairment was 0.93 (0.88–0.97) per 1-MET increment in CRF. When examined as a categorical variable, and using the lowest CRF quintile as the referent, there was a significantly reduced likelihood for cognitive impairment across the remaining ordered CRF categories (p trend = 0.004). Conclusion: The association between CRF and MoCA score in older adults suggests that meeting or exceeding public health guidelines for physical activity is likely to increase CRF in low fit individuals, maintain CRF in those with a moderate to high level of CRF, and thereby help to maintain cognitive function in healthy older adults.

scholarly journals Cytokine Responses to Acute Exercise in Healthy Older Adults: The Effect of Cardiorespiratory Fitness

2018 ◽  
Vol 9 ◽  
Author(s):  
Mark T. Windsor ◽  
Tom G. Bailey ◽  
Maria Perissiou ◽  
Lara Meital ◽  
Jonathan Golledge ◽  
...  
Keyword(s):  
Older Adults ◽  
Cardiorespiratory Fitness ◽  
Acute Exercise ◽  
Healthy Older Adults ◽  
Cytokine Responses

scholarly journals Cardiorespiratory fitness predicts greater hippocampal volume and rate of episodic associative learning in older adults

2019 ◽  
Author(s):  
Rachel C. Cole ◽  
Eliot Hazeltine ◽  
Timothy B. Weng ◽  
Conner Wharff ◽  
Lyndsey E. DuBose ◽  
...  
Keyword(s):  
Older Adults ◽  
Associative Learning ◽  
Cardiorespiratory Fitness ◽  
Sequence Learning ◽  
Hippocampal Volume ◽  
Learning Rate ◽  
Motor Sequence Learning ◽  
Aging Effects ◽  
Motor Sequence ◽  
Healthy Older Adults

ABSTRACTDeclining episodic memory is common among otherwise healthy older adults, in part due to negative effects of aging on hippocampal circuits. However, there is significant variability between individuals in severity of aging effects on the hippocampus and subsequent memory decline. Importantly, variability may be influenced by modifiable protective physiological factors such as cardiorespiratory fitness (CRF). More research is needed to better understand which aspects of cognition that decline with aging benefit most from CRF. The current study evaluated the relation of CRF with learning rate in the Episodic Associative Learning (EAL) task, a task designed specifically to target hippocampal-dependent relational binding and to evaluate learning with repeated occurrences. Results show that higher CRF was associated with larger hippocampal volume and faster learning rate. Larger hippocampal volume was also associated with faster learning rate, and hippocampal volume partially mediated the relationship between CRF and learning rate. Further, to support the distinction between learning item relations and learning higher-order sequences, which declines with aging but is largely reliant on extra-hippocampal learning systems, we found that EAL learning rate was not related to motor sequence learning on the alternating serial reaction time task. Motor sequence learning was also not correlated with hippocampal volume. Thus, for the first time we show that higher CRF in healthy older adults is related to enhanced rate of relational memory acquisition, in part mediated by benefits on the hippocampus.

scholarly journals Cardiorespiratory Fitness And Aortic Hemodynamics Are Associated With Brain Volume In Healthy Older Adults

2020 ◽  
Vol 52 (7S) ◽  
pp. 13-13
Author(s):  
Kathleen B. Miller ◽  
Anna J. Howery ◽  
Adam T. Corkery ◽  
Marlowe W. Eldridge ◽  
Awni Al-Subu ◽  
...  
Keyword(s):  
Older Adults ◽  
Cardiorespiratory Fitness ◽  
Brain Volume ◽  
Healthy Older Adults ◽  
Aortic Hemodynamics

Partner-Specific Communication Deficits in Individuals With Alzheimer's Disease

2020 ◽  
pp. 1-15
Author(s):  
Eun Jin Paek ◽  
Si On Yoon
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Referential Communication ◽  
Sorting Task ◽  
Audience Design ◽  
Healthy Older Adults ◽  
Communication Task ◽  
Design Skills ◽  
Referential Expressions

Purpose Speakers adjust referential expressions to the listeners' knowledge while communicating, a phenomenon called “audience design.” While individuals with Alzheimer's disease (AD) show difficulties in discourse production, it is unclear whether they exhibit preserved partner-specific audience design. The current study examined if individuals with AD demonstrate partner-specific audience design skills. Method Ten adults with mild-to-moderate AD and 12 healthy older adults performed a referential communication task with two experimenters (E1 and E2). At first, E1 and participants completed an image-sorting task, allowing them to establish shared labels. Then, during testing, both experimenters were present in the room, and participants described images to either E1 or E2 (randomly alternating). Analyses focused on the number of words participants used to describe each image and whether they reused shared labels. Results During testing, participants in both groups produced shorter descriptions when describing familiar images versus new images, demonstrating their ability to learn novel knowledge. When they described familiar images, healthy older adults modified their expressions depending on the current partner's knowledge, producing shorter expressions and more established labels for the knowledgeable partner (E1) versus the naïve partner (E2), but individuals with AD were less likely to do so. Conclusions The current study revealed that both individuals with AD and the control participants were able to acquire novel knowledge, but individuals with AD tended not to flexibly adjust expressions depending on the partner's knowledge state. Conversational inefficiency and difficulties observed in AD may, in part, stem from disrupted audience design skills.

Talk or Walk? Gait Speed over Self-Report in Association with Cognitive Speed in Healthy Older Adults

GeroPsych ◽  
2019 ◽  
Vol 32 (1) ◽  
pp. 41-52
Author(s):  
Matthew C. Costello ◽  
Shane J. Sizemore ◽  
Kimberly E. O’Brien ◽  
Lydia K. Manning
Keyword(s):  
Older Adults ◽  
Older Adult ◽  
Gait Speed ◽  
Well Being ◽  
Self Report ◽  
Subjective Report ◽  
Healthy Older Adults ◽  
Relative Value ◽  
Cognitive Speed ◽  
Age Range

Abstract. This study explores the relative value of both subjectively reported cognitive speed and gait speed in association with objectively derived cognitive speed. It also explores how these factors are affected by psychological and physical well-being. A group of 90 cognitively healthy older adults ( M = 73.38, SD = 8.06 years, range = 60–89 years) were tested in a three-task cognitive battery to determine objective cognitive speed as well as measures of gait speed, well-being, and subjective cognitive speed. Analyses indicated that gait speed was associated with objective cognitive speed to a greater degree than was subjective report, the latter being more closely related to well-being than to objective cognitive speed. These results were largely invariant across the 30-year age range of our older adult sample.

Effects of Depression on Cognitive Deterioration in Healthy Older Adults

2008 ◽  
Author(s):  
Daniel Heyanka ◽  
Sarah West ◽  
Eduardo Vargas ◽  
Charles J. Golden
Keyword(s):  
Older Adults ◽  
Cognitive Deterioration ◽  
Healthy Older Adults
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