scholarly journals The Muscle Carnosine Response to Beta-Alanine Supplementation: A Systematic Review With Bayesian Individual and Aggregate Data E-Max Model and Meta-Analysis

2020 ◽  
Vol 11 ◽  
Author(s):  
Nathália Saffioti Rezende ◽  
Paul Swinton ◽  
Luana Farias de Oliveira ◽  
Rafael Pires da Silva ◽  
Vinicius da Eira Silva ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Aggregate Data ◽  
Muscle Carnosine ◽  
Beta Alanine

scholarly journals Human Skeletal Muscle has Large Capacity to Increase Carnosine Content in Response to Beta-Alanine Supplementation. A Systematic Review with Bayesian Individual and Aggregate Data E-Max Model and Meta-Analysis

2019 ◽  
Author(s):  
Nathalia Saffioti Rezende ◽  
Paul Swinton ◽  
Luana Farias de Oliveira ◽  
Rafa Pires da Silva ◽  
Vinicius Eira da Silva ◽  
...  
Keyword(s):  
Systematic Review ◽  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Meta Analysis ◽  
Aggregate Data ◽  
Individual Data ◽  
Muscle Carnosine ◽  
Large Capacity ◽  
Beta Alanine ◽  
Emax Model

ABSTRACTBeta-alanine (BA) supplementation increases muscle carnosine content (MCarn), and is ergogenic in many situations. Currently, many questions on the nature of the Mcarn response to supplementation are open, and the response to these has considerable potential to enhance the efficacy and applications of this supplementation strategy.ObjectiveTo conduct a Bayesian analysis of available data on the Mcarn response to BA supplementation.MethodsA systematic review with meta-analysis of individual and published aggregate data using a dose response (Emax) model was conducted. The protocol was designed according to PRISMA guidelines. A three-step screening strategy was undertaken to identify studies that measured the Mcarn response to BA supplementation. In addition, individual data from 5 separate studies conducted in the authors’ laboratory were analysed. Data were extracted from all controlled and uncontrolled supplementation studies conducted on healthy humans. Meta-regression was used to consider the influence of potential moderators (including dose, sex, age, baseline Mcarn and analysis method used) on the primary outcome.Results and ConclusionThe Emax model indicated that human skeletal muscle has large capacity for non-linear Mcarn accumulation, and that commonly used BA supplementation protocols may not come close to saturating muscle carnosine content. Neither baseline values, nor sex, appear to influence subsequent response to supplementation. Analysis of individual data indicated that Mcarn is relatively stable in the absence of intervention, and effectually all participants respond to BA supplementation (99.3% response [95%CrI: 96.2 – 100]).

scholarly journals The Antioxidant Effect of Beta-Alanine or Carnosine Supplementation on Exercise-Induced Oxidative Stress: A Systematic Review and Meta-Analysis

2018 ◽  
Author(s):  
Elias de França ◽  
Fábio Santos Lira ◽  
Marcio Flávio Ruaro ◽  
Vinicius Barroso Hirota ◽  
Paula A. Faria Waziry ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Meta Analysis ◽  
Protein Carbonyl ◽  
Human Model ◽  
Sod Activity ◽  
Beta Alanine ◽  
Total Antioxidant ◽  
Acute Increase ◽  
Exercise Induced

The objective of this study was to perform a systematic review and meta-analysis of the articles that addressed the effect beta-alanine (BA) or carnosine supplementation on Physical exercise (PE)-induced oxidative stress (OS). We searched throughout PubMed, CAPES Periodic and SPORTDiscus human model peer review, randomized control studies with chronic BA or carnosine supplementation on PE-induced OS. We search papers published before May 2018.  A total of 128 citations were found. Only four articles met criteria for inclusion. All four studies used healthy young (21y) sedentary, recreationally active or athletic participants. After a chorionic BA (~30 days) or carnosine (14 days) supplementation, the studies evaluated PE-induced OS both immediately and several hours after exercise (0.5 to 48 h). In response to PE-induced OS, BA/carnosine supplementation increased total antioxidant capacity (TAC) and glutathione concentrations while decreased pro-oxidant markers and superoxide dismutase (SOD) activity. BA or carnosine supplementation did not prevent the increase in peroxidation markers (e.g., 8-isoprostane, protein carbonyl or malonaldehyde). In humans, following PE-induced OS, initial treatment trials of BA or carnosine supplementation seemed to increase TAC and GSH concentrations, while decreasing SOD activity. Also, albeit mitigating the acute increase in pro-oxidants, treatment did not decrease measured values of peroxidation markers.

scholarly journals Effect of Supplements on Endurance Exercise in the Older Population: Systematic Review

2020 ◽  
Vol 17 (14) ◽  
pp. 5224
Author(s):  
Alejandro Martínez-Rodríguez ◽  
Bernardo J. Cuestas-Calero ◽  
María Hernández-García ◽  
María Martíez-Olcina ◽  
Manuel Vicente-Martínez ◽  
...  
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Sodium Bicarbonate ◽  
Older Women ◽  
Meta Analysis ◽  
Individual Characteristics ◽  
Protein Supplementation ◽  
Older Population ◽  
Beta Alanine ◽  
Positive Effects

Background: Ageing is associated with changes of physical and physiological parameters, but there is evidence that regular physical activity could minimize these effects. Additionally, the older population presents a great risk of suboptimal nutrition. Therefore, the purpose of this study was to review the evidence of nutritional strategies and endurance exercises in the older population. Methods: A systematic review was performed based on the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement. The search was carried out in three different databases: PubMed, Web of Science, and SPORTDiscus. Results: Eight studies were included in the present review. The use of caffeine and beta-alanine supplementation with proteins have been found to be beneficial in both sexes. In older women, a balanced diet, an increase in protein, supplementation with beta hydroxy methyl butyrate, and supplementation with sodium bicarbonate have been favorable. However, no benefit has been seen in older men with sodium bicarbonate or ubiquinone supplementation. Nevertheless, the use of supplements should be prescribed according to individual characteristics and physical activity. Conclusions: Caffeine and high protein supplement with beta-alanine may provide positive effects in the older population. In addition, in older women, bicarbonate supplementation and beta-hydroxyethyl butyrate (HMB), lysine, and arginine supplementation have shown positive effects on exercise performance.

Prognostic value of c-MET in head and neck cancer: A systematic review and meta-analysis of aggregate data

Oral Oncology ◽  
2017 ◽  
Vol 74 ◽  
pp. 68-76 ◽  
Author(s):  
Petr Szturz ◽  
Marie Budíková ◽  
Jan B. Vermorken ◽  
Ivana Horová ◽  
Břetislav Gál ◽  
...  
Keyword(s):  
Systematic Review ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Aggregate Data

scholarly journals The antioxidant effect of beta-alanine or carnosine supplementation on exercise- induced oxidative stress: a systematic review and meta-analysis

2019 ◽  
Vol 12 (3) ◽  
pp. 21 ◽  
Author(s):  
Elias França ◽  
Fábio Santos Lira ◽  
Marcio Flávio Ruaro ◽  
Vinicius Barroso Hirota ◽  
Paula Faria Waziry ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Meta Analysis ◽  
Antioxidant Effect ◽  
Beta Alanine ◽  
Exercise Induced

O objetivo deste estudo foi realizar uma revisão sistemática e meta-análise dos artigos que abordaram o efeito da suplementação de BA ou carnosina sobre o estresse oxidativo (TE) induzido pelo exercício físico (EF). Antes de maio de 2018, pesquisamos em todo PubMed, CAPES Periodic e SPORTDiscus modelo humano de revisão por pares, estudos randomizados de controle com suplementação crônica de BA ou carnosina em SO induzida por PE. Um total de 128 citações foram encontradas. Apenas quatro artigos preencheram critérios para inclusão. Todos os quatro estudos utilizaram jovens saudáveis, sedentários, recreativos ou atléticos. Após uma suplementação crônica com BA ou carnosina, os estudos avaliaram a SG induzida por PE imediatamente e várias horas após o exercício (0,5 a 48 h). Em resposta ao SO induzido por PE, quando comparado ao placebo, a suplementação com BA / carnosina aumentou a capacidade antioxidante total [TAC; Tamanho do Efeito (ES) = 0,35, Intervalo de Confiança 95% (CI) 0,06 a 0,65, p = 0,02] e concentrações de glutationa (GSH; ES = 0,75, IC 95% 0,32 a 1,19, p = 0,0007) enquanto diminuiu os marcadores OS diretos ( ES = -1,19, IC 95% -1,48 a -0,80, p

scholarly journals The Antioxidant Effect of Beta-Alanine or Carnosine Supplementation on Exercise-Induced Oxidative Stress: A Systematic Review and Meta-Analysis

2018 ◽  
Author(s):  
Elias de França ◽  
Fábio Santos Lira ◽  
Marcio Flávio Ruaro ◽  
Vinicius Barroso Hirota ◽  
Paula A. Faria Waziry ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Meta Analysis ◽  
Human Model ◽  
Sod Activity ◽  
Beta Alanine ◽  
Total Antioxidant ◽  
Acute Increase ◽  
Randomized Control ◽  
Exercise Induced

The objective of this study was to perform a systematic review and meta-analysis of the articles that addressed the effect BA or carnosine supplementation on Physical exercise (PE)-induced oxidative stress (OS). Before May 2018 we searched throughout PubMed, CAPES Periodic and SPORTDiscus human model peer review, randomized control studies with chronic BA or carnosine supplementation on PE-induced OS. A total of 128 citations were found. Only four articles met criteria for inclusion. All four studies used healthy young sedentary, recreationally active or athletic participants. After a chronic BA (~30 days) or carnosine (14 days) supplementation, the studies evaluated PE-induced OS both immediately and several hours after exercise (0.5 to 48 h). In response to PE-induced OS, when compared to placebo, BA/carnosine supplementation increased total antioxidant capacity [TAC; Effect Size (ES) = 0.35, 95% Confidence Interval (CI) 0.06 to 0.65, p = 0.02] and glutathione (GSH; ES = 0.75, 95% CI 0.32 to 1.19, p = 0.0007) concentrations while decreased direct OS markers (ES = −1.19, 95% CI −1.48 to −0.80, p < 0.01) and superoxide dismutase (SOD) activity (ES = −0.58, 95% CI −1.10 to −0.06, p = 0.03). BA or carnosine supplementation did not prevent the increase in indirect OS markers (ES: −0.20, 95% CI −0.59 to 0.20, p = 0.33). In humans, following PE-induced OS, initial treatment trials of BA or carnosine supplementation seemed to increase TAC and GSH concentrations, while decreasing SOD activity. Also, albeit mitigating the acute increase in direct OS species (reactive nitrogen and oxygen species), treatment did not decrease measured values of indirect OS markers (peroxidation or molecule oxidation).

scholarly journals The Antioxidant Effect of Beta-Alanine or Carnosine Supplementation on Exercise-Induced Oxidative Stress: A Systematic Review and Meta-Analysis

2018 ◽  
Author(s):  
Elias de França ◽  
Fábio Santos Lira ◽  
Marcio Flávio Ruaro ◽  
Vinicius Barroso Hirota ◽  
Paula A. Faria Waziry ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Meta Analysis ◽  
Human Model ◽  
Sod Activity ◽  
Beta Alanine ◽  
Total Antioxidant ◽  
Acute Increase ◽  
Randomized Control ◽  
Exercise Induced

The objective of this study was to perform a systematic review and meta-analysis of the articles that addressed the effect BA or carnosine supplementation on physical exercise (PE)-induced oxidative stress (OS). Before May 2018 we searched throughout PubMed, CAPES Periodic and SPORTDiscus human model peer review, randomized control studies with chronic BA or carnosine supplementation on PE-induced OS. A total of 128 citations were found. Only four articles met criteria for inclusion. All four studies used healthy young sedentary, recreationally active or athletic participants. After a chronic BA or carnosine supplementation, the studies evaluated PE-induced OS both immediately and several hours after exercise (0.5 to 48 h). In response to PE-induced OS, when compared to placebo, BA/carnosine supplementation increased total antioxidant capacity [TAC; Effect Size (ES) = 0.35, 95% Confidence Interval (CI) 0.06 to 0.65, p = 0.02] and glutathione (GSH; ES = 0.75, 95% CI 0.32 to 1.19, p = 0.0007) concentrations while decreased direct OS markers (ES = −1.19, 95% CI −1.48 to −0.80, p < 0.01) and superoxide dismutase (SOD) activity (ES = − 0.58, 95% CI −1.10 to −0.06, p = 0.03). BA or carnosine supplementation did not prevent the increase in indirect OS markers (ES: 0.06, 95% CI −0.38 to 0.500, p = 0.80). In humans, following PE-induced OS, initial treatment trials of BA or carnosine supplementation seemed to increase TAC and GSH concentrations, while decreasing SOD activity. Also, albeit mitigating the acute increase in direct OS markers (reactive nitrogen and oxygen species), treatment did not decrease measured values of indirect OS markers (peroxidation or molecule oxidation).

scholarly journals Effects of Nutritional Interventions on Accuracy and Reaction Time with Relevance to Mental Fatigue in Sporting, Military, and Aerospace Populations: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 19 (1) ◽  
pp. 307
Author(s):  
Liam S. Oliver ◽  
John P. Sullivan ◽  
Suzanna Russell ◽  
Jonathan M. Peake ◽  
Mitchell Nicholson ◽  
...  
Keyword(s):  
Systematic Review ◽  
Reaction Time ◽  
Meta Analysis ◽  
Energy Drinks ◽  
Nutritional Intervention ◽  
Mental Fatigue ◽  
Negative Effects ◽  
Nutritional Interventions ◽  
Cognitive Domains ◽  
Beta Alanine

Background: Research in sport, military, and aerospace populations has shown that mental fatigue may impair cognitive performance. The effect of nutritional interventions that may mitigate such negative effects has been investigated. This systematic review and meta-analysis aimed to quantify the effects of nutritional interventions on cognitive domains often measured in mental fatigue research. Methods: A systematic search for articles was conducted using key terms relevant to mental fatigue in sport, military, and aerospace populations. Two reviewers screened 11,495 abstracts and 125 full texts. A meta-analysis was conducted whereby effect sizes were calculated using subgroups for nutritional intervention and cognitive domains. Results: Fourteen studies were included in the meta-analysis. The consumption of energy drinks was found to have a small positive effect on reaction time, whilst the use of beta-alanine, carbohydrate, and caffeine had no effect. Carbohydrate and caffeine use had no effect on accuracy. Conclusions: The results of this meta-analysis suggest that consuming energy drinks may improve reaction time. The lack of effect observed for other nutritional interventions is likely due to differences in the type, timing, dosage, and form of administration. More rigorous randomized controlled trials related to the effect of nutrition interventions before, during, and after induced mental fatigue are required.

Sign in / Sign up

Export Citation Format

Share Document