scholarly journals Oxytocin Reduces Intravesical Pressure in Anesthetized Female Rats: Action on Oxytocin Receptors of the Urinary Bladder

2020 ◽  
Vol 11 ◽  
Author(s):  
Eduardo M. Cafarchio ◽  
Luiz A. da Silva ◽  
Luciana C. Auresco ◽  
Itatiana F. Rodart ◽  
Janaina S. de Souza ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Female Rats ◽  
Intravesical Pressure ◽  
Oxytocin Receptors

Effects of capsaicin on micturition and associated reflexes in rats

1993 ◽  
Vol 265 (1) ◽  
pp. R132-R138 ◽  
Author(s):  
C. L. Cheng ◽  
C. P. Ma ◽  
W. C. de Groat
Keyword(s):  
Urinary Bladder ◽  
Large Dose ◽  
Urethral Catheter ◽  
Female Rats ◽  
Bladder Function ◽  
Intravesical Pressure ◽  
Pressor Responses ◽  
Bladder Activity ◽  
Micturition Volume ◽  
Stimulation Of

The effect of capsaicin on micturition and associated reflexes was studied in urethan-anesthetized female rats. Capsaicin or vehicle solution were administered 4 days before the experiment in a dose of 125 mg/kg sc or during the experiment in a dose of 50-100 mg/kg sc. Activity of the urinary bladder was recorded by measuring intravesical pressure via a urethral catheter while slowly filling (0.052 ml/min) the bladder or when the bladder was distended beyond the micturition threshold and maintained at a constant volume. Pretreatment with capsaicin did not significantly change various parameters of urinary bladder function including micturition volume threshold or the amplitude, duration, and interval between reflex bladder contractions. However, capsaicin pretreatment significantly reduced (80% decrease) the arterial pressor responses accompanying reflex bladder contractions and reduced by approximately one-half the percentage of animals in which bladder activity was inhibited by stimulation of the uterine cervix. A large dose of capsaicin (50 mg/kg sc) elicited an acute block of bladder activity that persisted for 8-15 h. This effect is attributable to an action on myelinated afferent or efferent components of the micturition reflex pathway. It is concluded that capsaicin-sensitive afferents are not essential for the performance of micturition in the rat. However, these afferents are involved in cervicovesical reflex mechanisms that modulate bladder activity and in vascular reflexes triggered by isometric bladder contractions.

scholarly journals Fourier analysis of electrical impedance variations in urinary bladder during changes of intravesical pressure

2010 ◽  
Vol 224 ◽  
pp. 012112 ◽  
Author(s):  
A V Sivkov ◽  
I S Mudraya ◽  
S V Revenko ◽  
A R Ibragimov ◽  
A V Nesterov ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Fourier Analysis ◽  
Electrical Impedance ◽  
Intravesical Pressure

Unravelling the intravenous and in situ vasopressin effects on the urinary bladder in anesthetized female rats: More than one vasopressin receptor subtype involved?

2018 ◽  
Vol 834 ◽  
pp. 109-117 ◽  
Author(s):  
Eduardo M. Cafarchio ◽  
Luciana C. Auresco ◽  
Luiz A. da Silva ◽  
Itatiana F. Rodart ◽  
Barbara do Vale ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Female Rats ◽  
Receptor Subtype ◽  
Vasopressin Receptor

Role of vasopressin V1A receptor in the urethral closure reflex in rats

2011 ◽  
Vol 300 (4) ◽  
pp. F976-F982 ◽  
Author(s):  
Hiroyuki Ueno ◽  
Masako Kuno ◽  
Yasushi Shintani ◽  
Izumi Kamo
Keyword(s):  
Spinal Cord ◽  
Pressure Rise ◽  
Physiological Role ◽  
Female Rats ◽  
Reflex Response ◽  
Abdominal Pressure ◽  
Intravesical Pressure ◽  
Urethral Closure ◽  
Urethral Resistance ◽  
Vasopressin V1a Receptor

An enhanced urethral closure reflex via the spinal cord is related to urethral resistance elevation during increased abdominal pressure. However, with the exception of monoamines, neurotransmitters modulating this reflex are not understood. We investigated whether the vasopressin V1A receptor (V1AR) is involved in the urethral closure reflex in urethane-anesthetized female rats. V1AR mRNA was highly expressed among the vasopressin receptor family in the total RNA purified from lamina IX in the spinal cord L6–S1 segment. In situ hybridization analysis of the spinal L6–S1 segment confirmed that these positive signals from the V1ARs were only detected in lamina IX. Intrathecally injected Arg8-vasopressin (AVP), an endogenous ligand, significantly increased urethral resistance during an intravesical pressure rise, and its effect was blocked by the V1AR antagonist. AVP did not increase urethral resistance in rats in which the pelvic nerves were transected bilaterally. Urethral closure reflex responses to the intravesical pressure rise increased by up to threefold compared with the baseline response after AVP administration in contrast to no increase by vehicle. In addition, intravenously and intrathecally injected V1AR antagonists decreased urethral resistance. These results suggest that V1AR stimulation in the spinal cord enhances the urethral closure reflex response, thereby increasing urethral resistance during an abdominal pressure rise and that V1AR plays a physiological role in preventing urine leakage.

Cholinergic activation of neurons in the medulla oblongata changes urinary bladder activity by plasma vasopressin release in female rats

2016 ◽  
Vol 776 ◽  
pp. 116-123 ◽  
Author(s):  
Eduardo M. Cafarchio ◽  
Luiz A. da Silva ◽  
Luciana C. Auresco ◽  
Cristiana A. Ogihara ◽  
Roberto L. Almeida ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Medulla Oblongata ◽  
Female Rats ◽  
Vasopressin Release ◽  
Plasma Vasopressin ◽  
Bladder Activity ◽  
Cholinergic Activation
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