scholarly journals Effects of Long-Term Estrogen Treatment on Micturition Behavior and the Sensory Neurons of the Urinary Bladder in Old Female Rats

2008 ◽  
Vol 81 (4) ◽  
pp. 462-467 ◽  
Author(s):  
Sumiyo Toji ◽  
Takeshi Watanabe ◽  
Ikuo Miyagawa
2011 ◽  
Vol 95 (4) ◽  
pp. 1478-1481 ◽  
Author(s):  
Aluana Carlos Santana ◽  
Carlos Alberto Soares da Costa ◽  
Luciana Armada ◽  
Gabrielle de Paula Lopes Gonzalez ◽  
Mariana dos Santos Ribeiro ◽  
...  

Diabetes ◽  
2003 ◽  
Vol 52 (9) ◽  
pp. 2363-2371 ◽  
Author(s):  
C. Cheng ◽  
D. W. Zochodne

2009 ◽  
Vol 10 (4) ◽  
pp. 374-380 ◽  
Author(s):  
Pamela Johnson Rowsey ◽  
Bonnie L. Metzger ◽  
John Carlson ◽  
Christopher J. Gordon

Long-term exercise training selectively alters serum cytokines involved in fever. Chronic exercise training has a number of effects on the immune system that may mimic the physiological response to fever. Female rats that voluntarily exercise on running wheels develop an elevated daytime core temperature after several weeks of training. It remains to be seen whether the elevation in daytime temperature involves inflammatory patterns characteristic of an infectious fever. We assessed whether chronic exercise training in the rat would alter levels of cytokines involved in fever. Female Sprague Dawley rats at 45 days of age weighing 90—110 g were divided into two groups (exercise and sedentary) and housed at an ambient temperature of 22°C. Interleukin-1 beta (IL-1β), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor alpha (TNF-α), iron, and zinc levels were analyzed. Rats underwent 8 weeks of exercise on running wheels. Exercise led to altered levels of some key cytokines that are involved in fever. Exercise animals had significantly higher IL-1β levels and lower IL-10 levels compared to sedentary animals. Although IL-6 levels were slightly lower in the exercise animals, these levels were not significantly affected by training. TNF-α activity was similar in the two groups. Training also led to a slight increase in serum zinc and decrease in serum unsaturated iron binding capacity (UIBC). The data suggest that chronic exercise training evokes immune responses that mimic some, but not all, aspects of fever. This may explain why exercise leads to elevated daytime core temperature.


Science ◽  
1987 ◽  
Vol 235 (4789) ◽  
pp. 685-687 ◽  
Author(s):  
K. Scholz ◽  
J. Byrne
Keyword(s):  

1993 ◽  
Vol 90 (23) ◽  
pp. 11411-11415 ◽  
Author(s):  
G A Clark ◽  
E R Kandel

Long-term synaptic facilitation at the connections of Aplysia sensory neurons onto their target cells involves alterations in gene expression. How then are the relevant cellular signals for the induction and expression of long-term synaptic changes conveyed between the nucleus and remote synaptic terminals? We have explored this question using a set of remote, peripheral terminals of siphon sensory cells, which are approximately 3 cm from the sensory cell body in the abdominal ganglion. We found that these remote synapses, like the proximal synapses previously studied in dissociated cell culture, can exhibit long-term facilitation 24 hr after cell-wide serotonin application. Furthermore, serotonin applications restricted to the remote synaptic terminals nevertheless produced long-term facilitation, indicating that signals generated in synaptic regions can trigger the long-term process, perhaps via retrograde signals to the nucleus to modify gene expression, followed by anterograde signals back to the terminal. Serotonin applications restricted to the cell body and proximal synapses of the sensory neuron also produced long-term facilitation at remote synapses, although to a lesser extent, suggesting that long-term facilitation is expressed cell-wide, but that superimposed on this cell-wide facilitation there appears to be a component that is synapse-specific.


2015 ◽  
Vol 25 (12) ◽  
pp. 2404-2415 ◽  
Author(s):  
Erica Zamberletti ◽  
Marina Gabaglio ◽  
Pamela Prini ◽  
Tiziana Rubino ◽  
Daniela Parolaro

2016 ◽  
Vol 60 (1) ◽  
pp. 28536 ◽  
Author(s):  
Noemi A. V. Roza ◽  
Luiz F. Possignolo ◽  
Adrianne C. Palanch ◽  
José A. R. Gontijo

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