scholarly journals Liquiritin, as a Natural Inhibitor of AKR1C1, Could Interfere With the Progesterone Metabolism

2019 ◽  
Vol 10 ◽  
Author(s):  
Chenming Zeng ◽  
Difeng Zhu ◽  
Jun You ◽  
Xiaowu Dong ◽  
Bo Yang ◽  
...  
Keyword(s):  
Progesterone Metabolism ◽  
Natural Inhibitor

Experimental Haemorrhagic Effect of Two-Domain Non-Glycosylated Tissue Factor Pathway Inhibitor Compared to Low Molecular Weight Heparin

1996 ◽  
Vol 75 (04) ◽  
pp. 585-589 ◽  
Author(s):  
Jan Holst ◽  
Bengt Lindblad ◽  
Stefan E Matthíasson ◽  
Ulf Stjernquist ◽  
Mirella Ezban ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Tissue Factor Pathway Inhibitor ◽  
Bleeding Time ◽  
Low Molecular Weight ◽  
Prophylactic Dose ◽  
Significant Prolongation ◽  
Kunitz Inhibitor ◽  
Rat Gastric Mucosa ◽  
Natural Inhibitor ◽  
Tissue Factor Pathway

SummaryThe glycosylated multivalent three-domain Kunitz inhibitor TFPI is a natural inhibitor of tissue factor-FVIIa complex in the presence of FXa. TFPI has an experimental antithrombotic capacity indistinguishable from LMWH in a prophylactic dose, regardless of glycosylation and of the third domain. An inherited equilibrium between antithrombosis and haemorrhage exists. The aim of the study was to evaluate whether a two-domain non-glycosylated TFPI (117QTFPI1−161) has a bleeding potential in a rat gastric mucosa model. Groups; placebo, LMWH (tinzaparin) 60 and 250 anti-Xa IU/kg and 117QTFPIM61−161 1.0 and 10.0 mg/kg, given i.v. (bolus injection), randomised double dummy design.All actively treated groups significantly prolonged both the bleeding volume (493-984 Μl) and the bleeding time (10-20 min) compared to placebo (41 Μl, 2 min). It was not possible to distinguish a difference between the lower dose of LMWH and 117QTFPI1−161 in either parameter (p = 0.23-0.71). The two doses of 117QTFPI1−161 caused elevation of plasma-TFPI, 18 and 150 times baseline value. Both LMWH doses (0.6-3.2 anti-Xa IU/ml) and both 117QTFPI1−161 doses (0.2-2.7 anti-Xa IU/ml), caused significant effect in the anti-Xa assay, however 117QTFPI1−161 significantly less. Only the largest dose of 117QTFPI1−161 caused significant prolongation in the APTT assay (34 s). Both doses of LMWH caused significant prolongation (60-300 s). LMWH was the only substance to prolong the dilute-PT assay.Non-glycosylated two-domain 1.0 mg/kg TFPI, yielding supra-physiological plasma concentration, has an experimental haemorrhagic potential indistinguishable from LMWH in a prophylactic dose. The effect mediated by this type of TFPI could primarily be due to an inhibition of FXa.

DEPENDENCE OF IN VITRO PROGESTERONE METABOLISM ON PROTEIN BINDING IN THE RAT UTERUS

1974 ◽  
Vol 77 (1_Suppl) ◽  
pp. S86
Author(s):  
D. Egert ◽  
W. Jonat ◽  
H. Maass
Keyword(s):  
Protein Binding ◽  
Rat Uterus ◽  
Progesterone Metabolism

TAMM HORSFALL PROTEIN: THE MEN BEHIND THE EPONYM

2019 ◽  
Vol 23 (2) ◽  
pp. 117-119 ◽  
Author(s):  
D. N. Paskalev ◽  
B. T. Galunska ◽  
D. Petkova-Valkova
Keyword(s):  
Viral Replication ◽  
Research Team ◽  
Molecular Mechanisms ◽  
Thick Ascending Limb ◽  
Rockefeller Institute ◽  
The Usa ◽  
Natural Inhibitor ◽  
Simplex Virus ◽  
First Time ◽  
New Protein

Tamm–Horsfall Protein (uromodulin) is named after Igor Tamm and Franc Horsfall Jr who described it for the first time in 1952. It is a glycoprotein, secreted by the cells in the thick ascending limb of the loop of Henle. This protein will perform a number of important pathophysiological functions, including protection against uroinfections, especially caused by E. Сoli, and protection against formation of calcium concernments in the kidney. Igor Tamm (1922-1995) is an outstanding cytologist, virologist and biochemist. He is one of the pioneers in the study of viral replication. He was born in Estonia and died in the USA. In 1964 he was elected for a professorship in Rockefeller Institute for Medical Research, where has been working continuously. Since 1959, he became a head of the virology lab established by his mentor and co-author Franc Horsfall. In the course of studies on the natural inhibitor of viral replication, Tamm and Horsfall isolated and characterized biochemically a new protein named after their names. Franc Lappin Horsfall Jr (1906-1971) was a well-known clinician and virologist with remarkable achievements in internal medicine. He was born and died in the USA. He worked in the Rockefeller Hospital from 1934 to 1960, then in the Center for Cancer Research at the Sloan-Kettering Institute. Here he was a leader of a research team studying the molecular mechanisms of immunity, the effects of chemotherapy with benzimidazole compounds (together with I. Tamm), coxsackie viruses, herpes simplex virus, etc. 

Oleuropein is a natural inhibitor of PAI-1-mediated proliferation in human ER-/PR- breast cancer cells

2021 ◽  
Author(s):  
Elena E. Tzekaki ◽  
George Geromichalos ◽  
Sophia N. Lavrentiadou ◽  
Maria P. Tsantarliotou ◽  
Anastasia A. Pantazaki ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Natural Inhibitor ◽  
Pai 1

Alternaria alternataCrofton-Weed Toxin:  a Natural Inhibitor of Photosystem II inChlamydomonas reinhardtiiThylakoids

2007 ◽  
Vol 55 (13) ◽  
pp. 5180-5185 ◽  
Author(s):  
Yu-Xiao Liu ◽  
Xiao-Ming Xu ◽  
Xin-Bin Dai ◽  
Sheng Qiang
Keyword(s):  
Photosystem Ii ◽  
Toxin A ◽  
Natural Inhibitor
Sign in / Sign up

Export Citation Format

Share Document