scholarly journals Comparison of the Reverse-Remodeling Effect of Pharmacological Soluble Guanylate Cyclase Activation With Pressure Unloading in Pathological Myocardial Left Ventricular Hypertrophy

2019 ◽  
Vol 9 ◽  
Author(s):  
Mihály Ruppert ◽  
Sevil Korkmaz-Icöz ◽  
Shiliang Li ◽  
Paige Brlecic ◽  
Balázs Tamás Németh ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Guanylate Cyclase ◽  
Ventricular Hypertrophy ◽  
Soluble Guanylate Cyclase ◽  
Left Ventricular ◽  
Reverse Remodeling ◽  
Cyclase Activation ◽  
Guanylate Cyclase Activation

scholarly journals Molecular steps in soluble guanylate cyclase activation

2005 ◽  
Vol 5 (Suppl 1) ◽  
pp. S1
Author(s):  
Elizabeth M Boon ◽  
Stephen PL Cary ◽  
Shirley H Huang ◽  
Jonathan A Winger ◽  
Michael A Marletta
Keyword(s):  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase ◽  
Cyclase Activation ◽  
Guanylate Cyclase Activation

Incomplete structural reverse remodeling from late-stage left ventricular hypertrophy impedes the recovery of diastolic but not systolic dysfunction in rats

2019 ◽  
Vol 37 (6) ◽  
pp. 1200-1212 ◽  
Author(s):  
Mihály Ruppert ◽  
Sevil Korkmaz-Icöz ◽  
Sivakkanan Loganathan ◽  
Weipeng Jiang ◽  
Attila Oláh ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Late Stage ◽  
Ventricular Hypertrophy ◽  
Systolic Dysfunction ◽  
Left Ventricular ◽  
Reverse Remodeling

Hydrogen peroxide elicits pulmonary arterial relaxation and guanylate cyclase activation

1987 ◽  
Vol 252 (4) ◽  
pp. H721-H732 ◽  
Author(s):  
T. M. Burke ◽  
M. S. Wolin
Keyword(s):  
Hydrogen Peroxide ◽  
Guanylate Cyclase ◽  
Superoxide Anion ◽  
Vascular Tone ◽  
Soluble Guanylate Cyclase ◽  
Compound I ◽  
Cyclase Activation ◽  
Arterial Relaxation ◽  
Pulmonary Arterial ◽  
Guanylate Cyclase Activation

Hydrogen peroxide produces concentration-dependent relaxation of precontracted isolated bovine intrapulmonary arterial rings by a mechanism which is independent of the endothelium or prostaglandin mediators. Relaxant responses to hydrogen peroxide concentrations of up to 100 microM were markedly attenuated by the inhibitor of soluble guanylate cyclase activation, methylene blue (10 microM). Micromolar concentrations of hydrogen peroxide elicit time- and concentration-dependent increase in arterial levels of guanosine 3',5'-cyclic monophosphate that are associated with decreases in force. Soluble guanylate cyclase activity is markedly activated by enzymatically generated hydrogen peroxide in a manner that is most closely associated with the concentration of catalase present in the assay, by a mechanism that is inhibited by superoxide anion and the inactivation of catalase. Our data are most consistent with the involvement of compound I, a species of catalase formed during the metabolism of peroxide, in the mechanism of guanylate cyclase activation. The nature of this mechanism of arterial relaxation suggests that it could contribute to the regulation of pulmonary vascular tone by oxygen tension.

Effects of soluble guanylate cyclase activation on heart transplantation in a rat model

2015 ◽  
Vol 34 (10) ◽  
pp. 1346-1353 ◽  
Author(s):  
Sivakkanan Loganathan ◽  
Sevil Korkmaz-Icöz ◽  
Tamás Radovits ◽  
Shiliang Li ◽  
Beatrice Mikles ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Guanylate Cyclase ◽  
Rat Model ◽  
Soluble Guanylate Cyclase ◽  
Cyclase Activation ◽  
Guanylate Cyclase Activation

Identification of residues crucially involved in soluble guanylate cyclase activation

FEBS Letters ◽  
2006 ◽  
Vol 580 (17) ◽  
pp. 4205-4213 ◽  
Author(s):  
Christiane Rothkegel ◽  
Peter M. Schmidt ◽  
Friederike Stoll ◽  
Henning Schröder ◽  
Harald H.H.W. Schmidt ◽  
...  
Keyword(s):  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase ◽  
Cyclase Activation ◽  
Guanylate Cyclase Activation
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