Identification of residues crucially involved in soluble guanylate cyclase activation

FEBS Letters ◽  
2006 ◽  
Vol 580 (17) ◽  
pp. 4205-4213 ◽  
Author(s):  
Christiane Rothkegel ◽  
Peter M. Schmidt ◽  
Friederike Stoll ◽  
Henning Schröder ◽  
Harald H.H.W. Schmidt ◽  
...  
Keyword(s):  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase ◽  
Cyclase Activation ◽  
Guanylate Cyclase Activation

scholarly journals Molecular steps in soluble guanylate cyclase activation

2005 ◽  
Vol 5 (Suppl 1) ◽  
pp. S1
Author(s):  
Elizabeth M Boon ◽  
Stephen PL Cary ◽  
Shirley H Huang ◽  
Jonathan A Winger ◽  
Michael A Marletta
Keyword(s):  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase ◽  
Cyclase Activation ◽  
Guanylate Cyclase Activation

Hydrogen peroxide elicits pulmonary arterial relaxation and guanylate cyclase activation

1987 ◽  
Vol 252 (4) ◽  
pp. H721-H732 ◽  
Author(s):  
T. M. Burke ◽  
M. S. Wolin
Keyword(s):  
Hydrogen Peroxide ◽  
Guanylate Cyclase ◽  
Superoxide Anion ◽  
Vascular Tone ◽  
Soluble Guanylate Cyclase ◽  
Compound I ◽  
Cyclase Activation ◽  
Arterial Relaxation ◽  
Pulmonary Arterial ◽  
Guanylate Cyclase Activation

Hydrogen peroxide produces concentration-dependent relaxation of precontracted isolated bovine intrapulmonary arterial rings by a mechanism which is independent of the endothelium or prostaglandin mediators. Relaxant responses to hydrogen peroxide concentrations of up to 100 microM were markedly attenuated by the inhibitor of soluble guanylate cyclase activation, methylene blue (10 microM). Micromolar concentrations of hydrogen peroxide elicit time- and concentration-dependent increase in arterial levels of guanosine 3',5'-cyclic monophosphate that are associated with decreases in force. Soluble guanylate cyclase activity is markedly activated by enzymatically generated hydrogen peroxide in a manner that is most closely associated with the concentration of catalase present in the assay, by a mechanism that is inhibited by superoxide anion and the inactivation of catalase. Our data are most consistent with the involvement of compound I, a species of catalase formed during the metabolism of peroxide, in the mechanism of guanylate cyclase activation. The nature of this mechanism of arterial relaxation suggests that it could contribute to the regulation of pulmonary vascular tone by oxygen tension.

Effects of soluble guanylate cyclase activation on heart transplantation in a rat model

2015 ◽  
Vol 34 (10) ◽  
pp. 1346-1353 ◽  
Author(s):  
Sivakkanan Loganathan ◽  
Sevil Korkmaz-Icöz ◽  
Tamás Radovits ◽  
Shiliang Li ◽  
Beatrice Mikles ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Guanylate Cyclase ◽  
Rat Model ◽  
Soluble Guanylate Cyclase ◽  
Cyclase Activation ◽  
Guanylate Cyclase Activation

scholarly journals Probing Soluble Guanylate Cyclase Activation by CO and YC-1 Using Resonance Raman Spectroscopy

Biochemistry ◽  
2010 ◽  
Vol 49 (18) ◽  
pp. 3815-3823 ◽  
Author(s):  
Mohammed Ibrahim ◽  
Emily R. Derbyshire ◽  
Michael A. Marletta ◽  
Thomas G. Spiro
Keyword(s):  
Raman Spectroscopy ◽  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase ◽  
Resonance Raman Spectroscopy ◽  
Resonance Raman ◽  
Cyclase Activation ◽  
Guanylate Cyclase Activation

scholarly journals Direct soluble guanylate cyclase activation improves vascular function in a mouse model of sickle cell disease

Nitric Oxide ◽  
2014 ◽  
Vol 42 ◽  
pp. 138
Author(s):  
Karin Potoka ◽  
Christina Mucci ◽  
Stephanie Mutchler ◽  
Marta Bueno ◽  
Eva Becker-Pelster ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Mouse Model ◽  
Sickle Cell ◽  
Guanylate Cyclase ◽  
Vascular Function ◽  
Soluble Guanylate Cyclase ◽  
Cell Disease ◽  
Cyclase Activation ◽  
Guanylate Cyclase Activation

scholarly journals Role of soluble guanylate cyclase activation in the gastroprotective effect of the HO-1/CO pathway against alendronate-induced gastric damage in rats

2013 ◽  
Vol 700 (1-3) ◽  
pp. 51-59 ◽  
Author(s):  
Natália R.D. Costa ◽  
Renan O. Silva ◽  
Lucas A.D. Nicolau ◽  
Larisse T. Lucetti ◽  
Ana Paula M. Santana ◽  
...  
Keyword(s):  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase ◽  
Gastric Damage ◽  
Cyclase Activation ◽  
Gastroprotective Effect ◽  
Guanylate Cyclase Activation
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