scholarly journals Changes of Intracellular Porphyrin, Reactive Oxygen Species, and Fatty Acids Profiles During Inactivation of Methicillin-Resistant Staphylococcus aureus by Antimicrobial Blue Light

2018 ◽  
Vol 9 ◽  
Author(s):  
Jiaxin Wu ◽  
Zhaojuan Chu ◽  
Zheng Ruan ◽  
Xiaoyuan Wang ◽  
Tianhong Dai ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Fatty Acids ◽  
Staphylococcus Aureus ◽  
Blue Light ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Methicillin Resistant

scholarly journals Annihilation of Methicillin-resistant Staphylococcus aureus via Photobleaching of Staphyloxanthin

2017 ◽  
Author(s):  
Pu-Ting Dong ◽  
Haroon Mohammad ◽  
Xiaoyu Wang ◽  
Jie Hui ◽  
Junjie Li ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Staphylococcus Aureus ◽  
Transient Absorption ◽  
Reactive Oxygen ◽  
Imaging Study ◽  
Infection Model ◽  
Oxygen Species ◽  
Methicillin Resistant ◽  
Antibiotic Development ◽  
Absorption Imaging

Given that the dearth of new antibiotic development loads an existential burden on successful infectious disease therapy1, health organizations are calling for alternative approaches to combat methicillin-resistant Staphylococcus aureus (MRSA) infections. Here, we report a drug-free photonic approach to eliminate MRSA through photobleaching of staphyloxanthin, an indispensable membrane-bound antioxidant of S. aureus2-5. The photobleaching process, uncovered through a transient absorption imaging study and quantitated by absorption spectroscopy and mass spectrometry, decomposes staphyloxanthin and sensitizes MRSA to reactive oxygen species attack. Consequently, staphyloxanthin bleaching by low-level blue light eradicates MRSA synergistically with external or internal reactive oxygen species. The effectiveness of this synergistic therapy is validated in MRSA culture, MRSA-infected macrophage cells, S. aureus biofilms, and a mouse wound infection model. Collectively, these findings highlight broad applications of staphyloxanthin photobleaching for treatment of MRSA infections.

scholarly journals Reactive Oxygen Species-Dependent Innate Immune Mechanisms Control Methicillin-Resistant Staphylococcus aureus Virulence in the Drosophila Larval Model

mBio ◽  
2021 ◽  
Author(s):  
Elodie Ramond ◽  
Anne Jamet ◽  
Xiongqi Ding ◽  
Daniel Euphrasie ◽  
Clémence Bouvier ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Staphylococcus Aureus ◽  
Virulence Factors ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Innate Immune ◽  
Oxygen Species ◽  
Methicillin Resistant ◽  
Content Type ◽  
Mrsa Strains

The pathogenicity of methicillin-resistant S. aureus (MRSA) strains relies on their ability to produce a wide variety of tightly regulated virulence factors. Current in vivo models to analyze host-pathogen interactions are limited and difficult to manipulate.

scholarly journals EFFECTS OF FATTY ACIDS ON PRODUCTION OF REACTIVE OXYGEN SPECIES (ROS) BY SKELETAL MUSCLE CELLS

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Renato Tadeu Nachbar ◽  
Augusto Ducati Luchessi ◽  
Tavane David Cambiaghi ◽  
Rafael Herling Lambertucci ◽  
Sandro Massao Hirabara ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Skeletal Muscle ◽  
Fatty Acids ◽  
Reactive Oxygen ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Oxygen Species

Piperine exhibits promising antibiofilm activity against Staphylococcus aureus by accumulating reactive oxygen species (ROS)

2021 ◽  
Vol 204 (1) ◽  
Author(s):  
Sharmistha Das ◽  
Payel Paul ◽  
Sudipta Chatterjee ◽  
Poulomi Chakraborty ◽  
Ranojit K. Sarker ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Staphylococcus Aureus ◽  
Reactive Oxygen ◽  
Antibiofilm Activity ◽  
Oxygen Species
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