scholarly journals Hemoglobin Changes After Long-Term Intermittent Work at High Altitude

2018 ◽  
Vol 9 ◽  
Author(s):  
Almaz Akunov ◽  
Akylbek Sydykov ◽  
Turgun Toktash ◽  
Anara Doolotova ◽  
Akpay Sarybaev
Keyword(s):  
High Altitude ◽  
Intermittent Work

scholarly journals Long-Term Intermittent Work at High Altitude: Right Heart Functional and Morphological Status and Associated Cardiometabolic Factors

2018 ◽  
Vol 9 ◽  
Author(s):  
Julio Brito ◽  
Patricia Siques ◽  
Rosario López ◽  
Raul Romero ◽  
Fabiola León-Velarde ◽  
...  
Keyword(s):  
High Altitude ◽  
Right Heart ◽  
Morphological Status ◽  
Cardiometabolic Factors ◽  
Intermittent Work

scholarly journals Simultaneous generalized and low-layer SCIDAR turbulence profiles at san pedro mártir observatory

2019 ◽  
Vol 490 (1) ◽  
pp. 1397-1405 ◽  
Author(s):  
R Avila ◽  
O Valdés-Hernández ◽  
L J Sánchez ◽  
I Cruz-González ◽  
J L Avilés ◽  
...  
Keyword(s):  
High Altitude ◽  
Wind Direction ◽  
Close Agreement ◽  
Baja California ◽  
Ground Level ◽  
Combined Effect ◽  
Moderate Altitude ◽  
San Pedro ◽  
Simultaneous Measurements

ABSTRACT We present optical turbulence profiles obtained with a Generalized SCIDAR (G-SCIDAR) and a low-layer SCIDAR (LOLAS) at the Observatorio Astronómico Nacional in San Pedro Mártir (OAN-SPM), Baja California, Mexico, during three observing campaigns in 2013, 2014, and 2015. The G-SCIDAR delivers profiles with moderate altitude-resolution (a few hundred metres) along the entire turbulent section of the atmosphere, while the LOLAS gives high altitude resolution (on the order of tens of metres) but only within the first few hundred metres. Simultaneous measurements were obtained on 2014 and allowed us to characterize in detail the combined effect of the local orography and wind direction on the turbulence distribution close to the ground. At the beginning of several nights, the LOLAS profiles show that turbulence peaks between 25 and 50 m above the ground, not at ground level as was expected. The G-SCIDAR profiles exhibit a peak within the first kilometre. In 55 per cent and 36 per cent of the nights stable layers are detected between 10 and 15 km and at 3 km, respectively. This distribution is consistent with the results obtained with a G-SCIDAR in 1997 and 2000 observing campaigns. Statistics computed with the 7891 profiles that have been measured at the OAN-SPM with a G-SCIDAR in 1997, 2000, 2014, and 2015 campaigns are presented. The seeing values calculated with each of those profiles have a median of 0.79, first and third quartiles of 0.51 and 1.08 arcsec, which are in close agreement with other long term seeing monitoring performed at the OAN-SPM.

scholarly journals Thin Air Resulting in High Pressure: Mountain Sickness and Hypoxia-Induced Pulmonary Hypertension

2017 ◽  
Vol 2017 ◽  
pp. 1-17 ◽  
Author(s):  
Jan Grimminger ◽  
Manuel Richter ◽  
Khodr Tello ◽  
Natascha Sommer ◽  
Henning Gall ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
High Altitude ◽  
Hypobaric Hypoxia ◽  
Current Knowledge ◽  
Treatment Options ◽  
Acute Response ◽  
Mechanisms Of Adaptation ◽  
Mountain Sickness

With rising altitude the partial pressure of oxygen falls. This phenomenon leads to hypobaric hypoxia at high altitude. Since more than 140 million people permanently live at heights above 2500 m and more than 35 million travel to these heights each year, understanding the mechanisms resulting in acute or chronic maladaptation of the human body to these circumstances is crucial. This review summarizes current knowledge of the body’s acute response to these circumstances, possible complications and their treatment, and health care issues resulting from long-term exposure to high altitude. It furthermore describes the characteristic mechanisms of adaptation to life in hypobaric hypoxia expressed by the three major ethnic groups permanently dwelling at high altitude. We additionally summarize current knowledge regarding possible treatment options for hypoxia-induced pulmonary hypertension by reviewing in vitro, rodent, and human studies in this area of research.

Adaptations to High-Altitude Hypoxia

2021 ◽  
Author(s):  
Cynthia M. Beall ◽  
Kingman P. Strohl
Keyword(s):  
High Altitude ◽  
Oxygen Delivery ◽  
Hemoglobin Concentration ◽  
Barometric Pressure ◽  
Ambient Air ◽  
Extreme Environment ◽  
Indigenous Populations ◽  
East African ◽  
Short Term

Biological anthropologists aim to explain the hows and whys of human biological variation using the concepts of evolution and adaptation. High-altitude environments provide informative natural laboratories with the unique stress of hypobaric hypoxia, which is less than usual oxygen in the ambient air arising from lower barometric pressure. Indigenous populations have adapted biologically to their extreme environment with acclimatization, developmental adaptation, and genetic adaptation. People have used the East African and Tibetan Plateaus above 3,000 m for at least 30,000 years and the Andean Plateau for at least 12,000 years. Ancient DNA shows evidence that the ancestors of modern highlanders have used all three high-altitude areas for at least 3,000 years. It is necessary to examine the differences in biological processes involved in oxygen exchange, transport, and use among these populations. Such an approach compares oxygen delivery traits reported for East African Amhara, Tibetans, and Andean highlanders with one another and with short-term visitors and long-term upward migrants in the early or later stages of acclimatization to hypoxia. Tibetan and Andean highlanders provide most of the data and differ quantitatively in biological characteristics. The best supported difference is the unelevated hemoglobin concentration of Tibetans and Amhara compared with Andean highlanders as well as short- and long-term upward migrants. Moreover, among Tibetans, several features of oxygen transfer and oxygen delivery resemble those of short-term acclimatization, while several features of Andean highlanders resemble the long-term responses. Genes and molecules of the oxygen homeostasis pathways contribute to some of the differences.

scholarly journals Long-Term High-Altitude Hypoxia and Alpha Adrenoceptor-Dependent Pulmonary Arterial Contractions in Fetal and Adult Sheep

2019 ◽  
Vol 10 ◽  
Author(s):  
Dafne Moretta ◽  
Demosthenes G. Papamatheakis ◽  
Daniel P. Morris ◽  
Paresh C. Giri ◽  
Quintin Blood ◽  
...  
Keyword(s):  
High Altitude ◽  
Altitude Hypoxia ◽  
Adult Sheep ◽  
Alpha Adrenoceptor ◽  
High Altitude Hypoxia ◽  
Pulmonary Arterial
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