scholarly journals Evaluation of Muscle microRNA Expression in Relation to Human Peripheral Insulin Sensitivity: A Cross-Sectional Study in Metabolically Distinct Subject Groups

2017 ◽  
Vol 8 ◽  
Author(s):  
Dennis Dahlmans ◽  
Alexandre Houzelle ◽  
Johanna A. Jörgensen ◽  
Esther Phielix ◽  
Lucas Lindeboom ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Cross Sectional Study ◽  
Microrna Expression ◽  
Sectional Study ◽  
Cross Sectional ◽  
Peripheral Insulin Sensitivity

Maternal age at childbirth is associated with offspring insulin sensitivity: a cross-sectional study in adult male siblings

2016 ◽  
Vol 86 (1) ◽  
pp. 52-59 ◽  
Author(s):  
Charlotte Verroken ◽  
Hans-Georg Zmierczak ◽  
Stefan Goemaere ◽  
Jean-Marc Kaufman ◽  
Bruno Lapauw
Keyword(s):  
Insulin Sensitivity ◽  
Adult Male ◽  
Maternal Age ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Myocardial Fat Accumulation Is Independent of Measures of Insulin Sensitivity

2015 ◽  
Vol 100 (8) ◽  
pp. 3060-3068 ◽  
Author(s):  
Ranganath Muniyappa ◽  
Radwa Noureldin ◽  
Ronald Ouwerkerk ◽  
Elizabeth Y. Liu ◽  
Ritu Madan ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Serum Triglyceride ◽  
Tolerance Test ◽  
Cross Sectional Study ◽  
Glucose Disposal ◽  
Sensitivity Index ◽  
Cross Sectional ◽  
Peripheral Insulin Sensitivity ◽  
Cardiac Steatosis ◽  
Myocardial Steatosis

Background: Myocardial steatosis, an independent predictor of diastolic dysfunction, is frequently present in type 2 diabetes mellitus. High free fatty acid flux, hyperglycemia, and hyperinsulinemia may play a role in myocardial steatosis. There are no prior studies examining the relationship between insulin sensitivity (antilipolytic and glucose disposal actions of insulin) and cardiac steatosis. Objective: Using a cross-sectional study design of individuals with and without metabolic syndrome (MetSyn), we examined the relationships between cardiac steatosis and the sensitivity of the antilipolytic and glucose disposal actions of insulin. Methods: Pericardial fat (PF) volume, intramyocardial and hepatic fat (MF and HF) content, visceral fat (VF) and sc fat content were assessed by magnetic resonance imaging in 77 subjects (49 without MetSyn and 28 with MetSyn). In a subset of the larger cohort (n = 52), peripheral insulin sensitivity index (SI) and adipocyte insulin sensitivity (Adipo-SI) were determined from an insulin-modified frequently sampled iv glucose tolerance test. The Quantitative Insulin Sensitivity Check Index was used as a surrogate for hepatic insulin sensitivity. Results: Individuals with the MetSyn had significantly higher body mass index, total body fat, and MF, PF, HF, and VF content. HF and VF, but not MF, were negatively correlated with the Quantitative Insulin Sensitivity Check Index, Adipo-SI, and SI. Stepwise regression revealed that waist circumference and serum triglyceride levels independently predicted MF and PF, respectively. Adipo-SI and serum triglyceride levels independently predict HF. Conclusion: Myocardial steatosis is unrelated to hepatic, adipocyte, or peripheral insulin sensitivity. Although it is frequently observed in insulin-resistant subjects, further studies are necessary to identify and delineate pathogenic mechanisms that differentially affect cardiac and hepatic steatosis.

scholarly journals Relationship between sleep disturbances, lipid profile and insulin sensitivity in type 1 diabetic patients: a cross-sectional study

2020 ◽  
Author(s):  
Ana Carolina Musser Tavares de Mattos ◽  
Yuri Sofiati Campos ◽  
Vitória Oliveira Fiorini ◽  
Yasmin Sab ◽  
Bruna Landeiro Tavares ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Lipid Profile ◽  
Sleep Disturbances ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Sectional Study ◽  
Cross Sectional ◽  
Type 1 Diabetic Patients

scholarly journals Insulin Sensitivity and Gynaecological Features of Infertile Cameroonian Females with Polycystic Ovary Syndrome: A Cross-Sectional Study

2017 ◽  
Vol 07 (13) ◽  
pp. 1247-1254
Author(s):  
Julius Sama Dohbit ◽  
Eugene Sobngwi ◽  
Jean Dupont Kemfang ◽  
Pascal Foumane ◽  
Joel Noutakdie Tochie ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Ovary Syndrome ◽  
Cross Sectional

scholarly journals Body composition and markers of cardiometabolic health in transgender youth compared to cisgender youth: a cross-sectional study

2019 ◽  
Author(s):  
Natalie J Nokoff ◽  
Sharon L Scarbro ◽  
Kerrie L Moreau ◽  
Philip Zeitler ◽  
Kristen J Nadeau ◽  
...  
Keyword(s):  
Body Composition ◽  
Insulin Sensitivity ◽  
Hormone Therapy ◽  
Body Fat ◽  
Lean Mass ◽  
Cross Sectional Study ◽  
Cardiometabolic Health ◽  
Sectional Study ◽  
Cross Sectional ◽  
Transgender Youth

AbstractContextUp to 1.8% of adolescents identify as transgender and many more seek care, yet the impact of gender affirming hormone therapy (GAHT) on cardiometabolic health is unknown.ObjectiveTo determine insulin sensitivity and body composition among transgender females (TF) and males (TM) on estradiol or testosterone, compared to cisgender females (CF) and males (CM).DesignPilot, cross-sectional study conducted from 2016-2018.Setting. Academic regional transgender referral center.ParticipantsTransgender adolescents on either testosterone or estradiol for at least 3 months were recruited. Nineteen TM were matched to 19 CM and 42 CF on pubertal stage and body mass index (BMI). Eleven TF were matched to 23 CF and 13 TF to 24 CM on age and BMI.Main Outcome Measure(s)1/[fasting insulin] and body composition (dual-energy absorptiometry, DXA).ResultsTotal body fat was lower in TM than CF (29±7 vs. 33±7%, p=0.002) and higher than CM (28±7 vs. 24±9%, p=0.047). TM had higher lean mass than CF (68±7 vs. 64±7%, p=0.002) and lower than CM (69± vs. 73±8%, p=0.029). Insulin sensitivity was not different between the groups.TF had lower body fat than CF (31±7 vs. 35±8%, p=0.033) and higher than CM (28±6 vs. 20±10, p=0.001). TF had higher lean mass than CF (66±6 vs. 62±7%, p=0.032) and lower than CM (69±5 vs. 77±9%, p=0.001). TF were more insulin resistant than CM (0.078±0.025 vs. 0.142±0.064, p=0.011).ConclusionsTransgender adolescents on GAHT have significant differences in body composition compared to cisgender controls, with a body composition intermediate between BMI-matched cisgender males and females. These changes in body composition may have consequences for the cardiometabolic health of transgender adolescents.PrecisTransgender youth on gender affirming hormone therapy have differences in their percent fat and lean mass compared to cisgender (non-transgender) youth.

scholarly journals Insulin Resistance is Associated with Central Pain in Patients with Fibromyalgia

2021 ◽  
pp. 175-184
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Hemoglobin A1c ◽  
Laboratory Data ◽  
Cross Sectional Study ◽  
Central Pain ◽  
Model Assessment ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hba1c Levels

BACKGROUND: Insulin resistance (IR) is a pathological condition in which cells fail to respond normally to insulin. IR has been associated with multiple conditions, including chronic pain. Fibromyalgia (FM) is one of the common generalized chronic painful conditions with an incidence rate affecting 3% to 6% of the population. Substantial interest and investigation into FM continue to generate many hypotheses. The relationship between IR and FM has not been explored. IR is known to cause abnormalities in the cerebral microvasculature, leading to focal hypoperfusion. IR also has been shown to cause cognitive impairment in FM patients, as in parkinsonism. As demonstrated by advanced imaging methods, similar brain perfusion abnormalities occur in the brain of patients with FM as with IR. OBJECTIVES: To determine the potential association between FM and IR. SETTING: Subspecialty pain medicine clinics. STUDY DESIGN: Observational cross-sectional study. METHODS: Laboratory data was extracted through a retrospective review of medical records from patients who had met the American College of Rheumatology (ACR) criteria for FM. The Hemoglobin A1c (HbA1c) values from 33 patients with FM were compared with the means of the glycated HbA1c levels of 2 control populations. In addition, established indices of IR [Quantitative Insulin Sensitivity Check Index (QUICKI) and the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)] were calculated in a subgroup of patients in whom the analytes necessary for these calculations were available. To assess for confounding factors, the associations between HbA1c, QUICKI, HOMA-IR, fasting insulin levels, and glucose, after controlling for age, were explored by multiple analyses of variance with relation to gender and ethnicity. RESULTS: We found an association between IR and FM that was independent of age, gender, and ethnicity. We found that patients with FM belong to a distinct population that can be segregated from the control groups by their HbA1c levels, a surrogate marker of IR. This was demonstrated by analyzing the data after introducing an age correction into a linear regression model. This strategy showed significant differences between patients with FM and control subjects (P < 0.0001 and P = 0.0002, for 2 separate control populations, respectively). A subgroup analysis using the QUICKI and HOMA-IR showed that all patients with FM in this subgroup (100%) exhibited laboratory abnormalities pointing to IR. LIMITATIONS: Small observational cross-sectional study. There are also intrinsic limitations that are attributed to cross-sectional studies. CONCLUSION: The association demonstrated in this study warrant further investigation, including the pursuit of randomized, double-blind clinical trials to determine the effect of improving insulin sensitivity in FM related pain scores. Such studies could unveil a potential pathogenetic relationship between FM, central pain, and IR. Based on these initial findings, we present the hypothesis that IR may underlie pathological mechanisms leading to central pain. If confirmed, this may lead to a paradigm shift in the management of central pain. KEY WORDS: Fibromyalgia, insulin resistance, chronic widespread pain, hemoglobin A1c

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