scholarly journals Calcineurin/NFAT Activation-Dependence of Leptin Synthesis and Vascular Growth in Response to Mechanical Stretch

2016 ◽  
Vol 7 ◽  
Author(s):  
Nadia Soudani ◽  
Crystal M. Ghantous ◽  
Zein Farhat ◽  
Wassim N. Shebaby ◽  
Kazem Zibara ◽  
...  
2014 ◽  
Vol 62 (S 01) ◽  
Author(s):  
S. Dhein ◽  
A. Schreiber ◽  
S. Steinbach ◽  
M. Kostelka ◽  
F.W. Mohr

2020 ◽  
Vol 27 (31) ◽  
pp. 5159-5174 ◽  
Author(s):  
Xinjie Lu

Background:Angiopoietin-Like Proteins (ANGPTLs) are structurally related to the angiopoietins. A total of eight ANGPTLs (from ANGPTL1 to ANGPTL8) have been identified so far. Most ANGPTLs possess multibiological functions on lipid metabolism, atherosclerosis, and cancer. Among them, ANGPTL3 has been shown to regulate the levels of Very Low-Density Lipoprotein (VLDL) made by the liver and play a crucial role in human lipoprotein metabolism.Method:A systematic appraisal of ANGPTLs was conducted, focusing on the main features of ANGPTL3 that has a significant role in atherosclerosis.Results:Angiopoietins including ANGPTL3 are vascular growth factors that are highly specific for endothelial cells, perform a variety of other regulatory activities to influence inflammation, and have been shown to possess both pro-atherosclerotic and atheroprotective effects.Conclusion:ANGPTL3 has been demonstrated as a promising target in the pharmacological management of atherosclerosis. However, many questions remain about its biological functions.


Author(s):  
Nikoleta Tellios ◽  
Mary Feng ◽  
Nancy Chen ◽  
Hong Liu ◽  
Vasiliki Tellios ◽  
...  

2021 ◽  
Author(s):  
Shavali Shaik ◽  
Shinji Maegawa ◽  
Amanda R Haltom ◽  
Feng Wang ◽  
Xue Xiao ◽  
...  
Keyword(s):  

2021 ◽  
pp. 004051752110191
Author(s):  
Hiroyuki Kanai ◽  
Kentaro Ogawa ◽  
Tetsu Sasagawa ◽  
Kiyohiro Shibata

The stretch property of fabrics is one of the most important factors that provide comfort to wearers. It is expected that tension building up in the fabric can be relaxed and the garment pressure on the body can be reduced by appropriately exploiting its stretch property. Currently, the stretch property is predominantly realized using spandex. However, weaving or knitting elastic threads cannot be employed for the worsted fabric used to design men’s suits because of their effects on the mechanical properties of the fabric (e.g., embrittlement), which deteriorate with time. In this study, worsted fabric with a graded mechanical stretch property was produced, and the effect of the mechanical stretch property on comfort was verified. The mechanical stretch property is developed from the tension relaxation and fabric shrinkage along the weft yarn during the crabbing, scouring, and drying stages of the finishing process. Then, the form of the fabric is set by heating. In this study, the worsted fabric had an elongation ratio varying from 5.9% to 16.1% along the weft direction that was produced without using elastic thread. Furthermore, men’s suit pants were made from the fabrics. The effect of the stretch property on the garment comfort was verified through sensory evaluation and garment pressure measurement. The contribution of the mechanical stretch property in improving the garment comfort of men’s suit pants is discussed.


Author(s):  
Lili Dong ◽  
Yang Song ◽  
Yajie Zhang ◽  
Weikang Zhao ◽  
Chunli Wang ◽  
...  

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yu Zhang ◽  
Christopher D. Kontos ◽  
Brian H. Annex ◽  
Aleksander S. Popel

AbstractThe Ang–Tie signaling pathway is an important vascular signaling pathway regulating vascular growth and stability. Dysregulation in the pathway is associated with vascular dysfunction and numerous diseases that involve abnormal vascular permeability and endothelial cell inflammation. The understanding of the molecular mechanisms of the Ang–Tie pathway has been limited due to the complex reaction network formed by the ligands, receptors, and molecular regulatory mechanisms. In this study, we developed a mechanistic computational model of the Ang–Tie signaling pathway validated against experimental data. The model captures and reproduces the experimentally observed junctional localization and downstream signaling of the Ang–Tie signaling axis, as well as the time-dependent role of receptor Tie1. The model predicts that Tie1 modulates Tie2’s response to the context-dependent agonist Ang2 by junctional interactions. Furthermore, modulation of Tie1’s junctional localization, inhibition of Tie2 extracellular domain cleavage, and inhibition of VE-PTP are identified as potential molecular strategies for potentiating Ang2’s agonistic activity and rescuing Tie2 signaling in inflammatory endothelial cells.


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