CCN1 Protein Promotes Mechanical-Stretch-Induced Skin Regeneration by Activating Epithelial-Mesenchymal Transition

2018 ◽  
Author(s):  
Yiwen Zhou ◽  
Haizhou Li ◽  
Xiao Liang ◽  
Hengyu Du ◽  
Yinjun So ◽  
...  
Keyword(s):  
Epithelial Mesenchymal Transition ◽  
Mechanical Stretch ◽  
Skin Regeneration ◽  
Mesenchymal Transition

scholarly journals Resolvin D1 attenuates mechanical stretch-induced pulmonary fibrosis via epithelial-mesenchymal transition

2019 ◽  
Vol 316 (6) ◽  
pp. L1013-L1024 ◽  
Author(s):  
Yiyi Yang ◽  
Lisha Hu ◽  
Haifa Xia ◽  
Lin Chen ◽  
Shunan Cui ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Pulmonary Fibrosis ◽  
Lung Fibrosis ◽  
Epithelial Mesenchymal Transition ◽  
Mechanical Stretch ◽  
Formyl Peptide Receptor ◽  
Pathological Feature ◽  
Resolvin D1 ◽  
Acid Aspiration ◽  
Mesenchymal Transition

Mechanical ventilation-induced pulmonary fibrosis plays an important role in the high mortality rate of acute respiratory distress syndrome (ARDS). Resolvin D1 (RvD1) displays potent proresolving activities. Epithelial-mesenchymal transition (EMT) has been proved to be an important pathological feature of lung fibrosis. This study aimed to investigate whether RvD1 can attenuate mechanical ventilation-induced lung fibrosis. Human lung epithelial (BEAS-2B) cells were pretreated with RvD1 for 30 min and exposed to acid for 10 min before being subjected to mechanical stretch for 48 h. C57BL/6 mice were subjected to intratracheal acid aspiration followed by mechanical ventilation 24 h later (peak inspiratory pressure 22 cmH2O, positive end-expiratory pressure 2 cmH2O, and respiratory rate 120 breaths/min for 2 h). RvD1 was injected into mice for 5 consecutive days after mechanical ventilation. Treatment with RvD1 significantly inhibited mechanical stretch-induced mesenchymal markers (vimentin and α-smooth muscle actin) and stimulated epithelial markers (E-cadherin). Tert-butyloxycarbonyl 2 (BOC-2), a lipoxin A4 receptor/formyl peptide receptor 2 (ALX/FPR2) antagonist, is known to inhibit ALX/FPR2 function. BOC-2 could reverse the beneficial effects of RvD1. The antifibrotic effect of RvD1 was associated with the suppression of Smad2/3 phosphorylation. This study demonstrated that mechanical stretch could induce EMT and pulmonary fibrosis and that treatment with RvD1 could attenuate mechanical ventilation-induced lung fibrosis, thus highlighting RvD1 as an effective therapeutic agent against pulmonary fibrosis associated with mechanical ventilation.

scholarly journals Mechanical Stretch Induces Epithelial-Mesenchymal Transition in Alveolar Epithelia via Hyaluronan Activation of Innate Immunity

2011 ◽  
Vol 286 (20) ◽  
pp. 17435-17444 ◽  
Author(s):  
Rebecca L. Heise ◽  
Vandy Stober ◽  
Chaitra Cheluvaraju ◽  
John W. Hollingsworth ◽  
Stavros Garantziotis
Keyword(s):  
Innate Immunity ◽  
Epithelial Mesenchymal Transition ◽  
Mechanical Stretch ◽  
Mesenchymal Transition

Epithelial mesenchymal transition, stromal density, and chemo-resistance in breast cancer (BrCa)

2019 ◽  
Author(s):  
Andrew Redfern ◽  
Veenoo Agarwal ◽  
Lisa Spalding ◽  
Tony Blick ◽  
Alexander Dobrovic ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition
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