scholarly journals Peroxisome degradation in mammals: mechanisms of action, recent advances, and perspectives

2013 ◽  
Vol 4 ◽  
Author(s):  
Marcus Nordgren ◽  
Bo Wang ◽  
Oksana Apanasets ◽  
Marc Fransen
Keyword(s):  
Mechanisms Of Action ◽  
Recent Advances

Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action

2017 ◽  
Vol 37 (6) ◽  
pp. 1492-1517 ◽  
Author(s):  
Yin Kwan Wong ◽  
Chengchao Xu ◽  
Karunakaran A. Kalesh ◽  
Yingke He ◽  
Qingsong Lin ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Mechanisms Of Action ◽  
Recent Advances

scholarly journals Emerging mechanisms of dynein transport in the cytoplasm versus the cilium

2018 ◽  
Vol 46 (4) ◽  
pp. 967-982 ◽  
Author(s):  
Anthony J. Roberts
Keyword(s):  
Intraflagellar Transport ◽  
Cytoplasmic Dynein ◽  
Mechanisms Of Action ◽  
Cell Interior ◽  
Long Distance ◽  
Cargo Transport ◽  
Recent Advances ◽  
Human Disorders ◽  
Cilia And Flagella

Two classes of dynein power long-distance cargo transport in different cellular contexts. Cytoplasmic dynein-1 is responsible for the majority of transport toward microtubule minus ends in the cell interior. Dynein-2, also known as intraflagellar transport dynein, moves cargoes along the axoneme of eukaryotic cilia and flagella. Both dyneins operate as large ATP-driven motor complexes, whose dysfunction is associated with a group of human disorders. But how similar are their mechanisms of action and regulation? To examine this question, this review focuses on recent advances in dynein-1 and -2 research, and probes to what extent the emerging principles of dynein-1 transport could apply to or differ from those of the less well-understood dynein-2 mechanoenzyme.

Recent advances in experimental polyphosphazene adjuvants and their mechanisms of action

2018 ◽  
Vol 374 (3) ◽  
pp. 465-471 ◽  
Author(s):  
Royford Magiri ◽  
George Mutwiri ◽  
Heather L. Wilson
Keyword(s):  
Mechanisms Of Action ◽  
Recent Advances

Molecular mechanisms of action of quercetin in cancer: recent advances

Tumor Biology ◽  
2016 ◽  
Vol 37 (10) ◽  
pp. 12927-12939 ◽  
Author(s):  
Dharambir Kashyap ◽  
Sonam Mittal ◽  
Katrin Sak ◽  
Paavan Singhal ◽  
Hardeep Singh Tuli
Keyword(s):  
Molecular Mechanisms ◽  
Mechanisms Of Action ◽  
Recent Advances

Recent Development of 1,2,4-triazole-containing Compounds as Anticancer Agents

2020 ◽  
Vol 20 (16) ◽  
pp. 1441-1460 ◽  
Author(s):  
Xiaoyue Wen ◽  
Yongqin Zhou ◽  
Junhao Zeng ◽  
Xinyue Liu
Keyword(s):  
Anticancer Activity ◽  
Anticancer Agents ◽  
Mechanisms Of Action ◽  
Triazole Derivatives ◽  
Recent Advances

1,2,4-Triazole derivatives possess promising in vitro and in vivo anticancer activity, and many anticancer agents such as fluconazole, tebuconazole, triadimefon, and ribavirin bear a 1,2,4-triazole moiety, revealing their potential in the development of novel anticancer agents. This review emphasizes the recent advances in 1,2,4-triazole-containing compounds with anticancer potential, and the structureactivity relationships as well as mechanisms of action are also discussed.

scholarly journals The Roles of NO and H2S in Sperm Biology: Recent Advances and New Perspectives

2020 ◽  
Vol 21 (6) ◽  
pp. 2174
Author(s):  
Martin Kadlec ◽  
José Luis Ros-Santaella ◽  
Eliana Pintus
Keyword(s):  
Assisted Reproductive Technologies ◽  
Male Gamete ◽  
Cell Types ◽  
Reproductive Technologies ◽  
Mechanisms Of Action ◽  
Sperm Function ◽  
Sperm Cells ◽  
Cellular Functions ◽  
Recent Advances ◽  
Potential Use

After being historically considered as noxious agents, nitric oxide (NO) and hydrogen sulfide (H2S) are now listed as gasotransmitters, gaseous molecules that play a key role in a variety of cellular functions. Both NO and H2S are endogenously produced, enzymatically or non-enzymatically, and interact with each other in a range of cells and tissues. In spite of the great advances achieved in recent decades in other biological systems, knowledge about H2S function and interactions with NO in sperm biology is in its infancy. Here, we aim to provide an update on the importance of these molecules in the physiology of the male gamete. Special emphasis is given to the most recent advances in the metabolism, mechanisms of action, and effects (both physiological and pathophysiological) of these gasotransmitters. This manuscript also illustrates the physiological implications of NO and H2S observed in other cell types, which might be important for sperm function. The relevance of these gasotransmitters to several signaling pathways within sperm cells highlights their potential use for the improvement and successful application of assisted reproductive technologies.

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