Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action

2017 ◽  
Vol 37 (6) ◽  
pp. 1492-1517 ◽  
Author(s):  
Yin Kwan Wong ◽  
Chengchao Xu ◽  
Karunakaran A. Kalesh ◽  
Yingke He ◽  
Qingsong Lin ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Mechanisms Of Action ◽  
Recent Advances

scholarly journals Emerging mechanisms of dynein transport in the cytoplasm versus the cilium

2018 ◽  
Vol 46 (4) ◽  
pp. 967-982 ◽  
Author(s):  
Anthony J. Roberts
Keyword(s):  
Intraflagellar Transport ◽  
Cytoplasmic Dynein ◽  
Mechanisms Of Action ◽  
Cell Interior ◽  
Long Distance ◽  
Cargo Transport ◽  
Recent Advances ◽  
Human Disorders ◽  
Cilia And Flagella

Two classes of dynein power long-distance cargo transport in different cellular contexts. Cytoplasmic dynein-1 is responsible for the majority of transport toward microtubule minus ends in the cell interior. Dynein-2, also known as intraflagellar transport dynein, moves cargoes along the axoneme of eukaryotic cilia and flagella. Both dyneins operate as large ATP-driven motor complexes, whose dysfunction is associated with a group of human disorders. But how similar are their mechanisms of action and regulation? To examine this question, this review focuses on recent advances in dynein-1 and -2 research, and probes to what extent the emerging principles of dynein-1 transport could apply to or differ from those of the less well-understood dynein-2 mechanoenzyme.

Recent advances in experimental polyphosphazene adjuvants and their mechanisms of action

2018 ◽  
Vol 374 (3) ◽  
pp. 465-471 ◽  
Author(s):  
Royford Magiri ◽  
George Mutwiri ◽  
Heather L. Wilson
Keyword(s):  
Mechanisms Of Action ◽  
Recent Advances

Recent advances in pharmacogenetic approaches to anticancer drug development

2004 ◽  
Vol 62 (3) ◽  
pp. 233-253 ◽  
Author(s):  
Nicola F. Smith ◽  
William D. Figg ◽  
Alex Sparreboom
Keyword(s):  
Drug Development ◽  
Anticancer Drug ◽  
Recent Advances ◽  
Anticancer Drug Development

Molecular mechanisms of action of quercetin in cancer: recent advances

Tumor Biology ◽  
2016 ◽  
Vol 37 (10) ◽  
pp. 12927-12939 ◽  
Author(s):  
Dharambir Kashyap ◽  
Sonam Mittal ◽  
Katrin Sak ◽  
Paavan Singhal ◽  
Hardeep Singh Tuli
Keyword(s):  
Molecular Mechanisms ◽  
Mechanisms Of Action ◽  
Recent Advances

Recent Development of 1,2,4-triazole-containing Compounds as Anticancer Agents

2020 ◽  
Vol 20 (16) ◽  
pp. 1441-1460 ◽  
Author(s):  
Xiaoyue Wen ◽  
Yongqin Zhou ◽  
Junhao Zeng ◽  
Xinyue Liu
Keyword(s):  
Anticancer Activity ◽  
Anticancer Agents ◽  
Mechanisms Of Action ◽  
Triazole Derivatives ◽  
Recent Advances

1,2,4-Triazole derivatives possess promising in vitro and in vivo anticancer activity, and many anticancer agents such as fluconazole, tebuconazole, triadimefon, and ribavirin bear a 1,2,4-triazole moiety, revealing their potential in the development of novel anticancer agents. This review emphasizes the recent advances in 1,2,4-triazole-containing compounds with anticancer potential, and the structureactivity relationships as well as mechanisms of action are also discussed.

scholarly journals Peroxisome degradation in mammals: mechanisms of action, recent advances, and perspectives

2013 ◽  
Vol 4 ◽  
Author(s):  
Marcus Nordgren ◽  
Bo Wang ◽  
Oksana Apanasets ◽  
Marc Fransen
Keyword(s):  
Mechanisms Of Action ◽  
Recent Advances
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