scholarly journals Immunological Changes During Space Travel: A Ground-Based Evaluation of the Impact of Neutron Dose Rate on Plasma Cytokine Levels in Human Whole Blood Cultures

2020 ◽  
Vol 8 ◽  
Author(s):  
Randall Fisher ◽  
Bjorn Baselet ◽  
Randy Vermeesen ◽  
Marjan Moreels ◽  
Sarah Baatout ◽  
...  
Keyword(s):  
Dose Rate ◽  
Whole Blood ◽  
Blood Cultures ◽  
Space Travel ◽  
Plasma Cytokine ◽  
Human Whole Blood ◽  
Cytokine Levels ◽  
Immunological Changes ◽  
The Impact ◽  
Neutron Dose Rate

scholarly journals Levonadifloxacin, a Novel Benzoquinolizine Fluoroquinolone, Modulates Lipopolysaccharide-Induced Inflammatory Responses in Human Whole-Blood Assay and Murine Acute Lung Injury Model

2020 ◽  
Vol 64 (5) ◽  
Author(s):  
Anasuya Patel ◽  
Ganesh V. Sangle ◽  
Jinal Trivedi ◽  
Sushant A. Shengule ◽  
Deepak Thorve ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Whole Blood ◽  
Inflammatory Responses ◽  
Immunomodulatory Activity ◽  
Human Whole Blood ◽  
Injury Model ◽  
Cytokine Levels ◽  
Lung Injury Model ◽  
Clinical Benefits

ABSTRACT Fluoroquinolones are reported to possess immunomodulatory activity; hence, a novel benzoquinolizine fluoroquinolone, levonadifloxacin, was evaluated in lipopolysaccharide-stimulated human whole-blood (HWB) and mouse acute lung injury (ALI) models. Levonadifloxacin significantly mitigated the inflammatory responses in an HWB assay through inhibition of proinflammatory cytokines and in the ALI model by lowering lung total white blood cell count, myeloperoxidase, and cytokine levels. The immunomodulatory effect of levonadifloxacin, along with promising antibacterial activity, is expected to provide clinical benefits in the treatment of infections.

scholarly journals Impact of different antimycotics on cytokine levels in an in vitro aspergillosis model in human whole blood

Infection ◽  
2019 ◽  
Vol 48 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Zoe Oesterreicher ◽  
Sabine Eberl ◽  
Markus Zeitlinger
Keyword(s):  
Whole Blood ◽  
Human Whole Blood ◽  
Cytokine Levels

scholarly journals Acute high-intensity interval exercise reduces human monocyte Toll-like receptor 2 expression in type 2 diabetes

2017 ◽  
Vol 312 (4) ◽  
pp. R529-R538 ◽  
Author(s):  
Cody Durrer ◽  
Monique Francois ◽  
Helena Neudorf ◽  
Jonathan P. Little
Keyword(s):  
Type 2 Diabetes ◽  
Whole Blood ◽  
Blood Cultures ◽  
Toll Like Receptor ◽  
Single Session ◽  
Tnf Α ◽  
Anti Inflammatory ◽  
High Intensity Interval ◽  
The Impact

Type 2 diabetes (T2D) is characterized by chronic low-grade inflammation that contributes to disease pathophysiology. Exercise has anti-inflammatory effects, but the impact of high-intensity interval training (HIIT) is not known. The purpose of this study was to determine the impact of a single session of HIIT on cellular, molecular, and circulating markers of inflammation in individuals with T2D. Participants with T2D ( n = 10) and healthy age-matched controls (HC; n = 9) completed an acute bout of HIIT (7 × 1 min at ~85% maximal aerobic power output, separated by 1 min of recovery) on a cycle ergometer with blood samples obtained before (Pre), immediately after (Post), and at 1 h of recovery (1-h Post). Inflammatory markers on leukocytes were measured by flow cytometry, and TNF-α was assessed in both LPS-stimulated whole blood cultures and plasma. A single session of HIIT had an overall anti-inflammatory effect, as evidenced by 1) significantly lower levels of Toll-like receptor (TLR) 2 surface protein expression on both classical and CD16+ monocytes assessed at Post and 1-h Post compared with Pre ( P < 0.05 for all); 2) significantly lower LPS-stimulated TNF-α release in whole blood cultures at 1-h Post ( P < 0.05 vs. Pre); and 3) significantly lower levels of plasma TNF-α at 1-h Post ( P < 0.05 vs. Pre). There were no differences between T2D and HC, except for a larger decrease in plasma TNF-α in HC vs. T2D (group × time interaction, P < 0.05). One session of low-volume HIIT has immunomodulatory effects and provides potential anti-inflammatory benefits to people with, and without, T2D.

Inflammatory Activity as an Indicator of Water Quality: The use of human whole blood cultures

2000 ◽  
Vol 21 (4) ◽  
pp. 387-399 ◽  
Author(s):  
Edmund J. Pool ◽  
Johannes H. van Wyk ◽  
Alison J. Leslie
Keyword(s):  
Water Quality ◽  
Whole Blood ◽  
Blood Cultures ◽  
Inflammatory Activity ◽  
Human Whole Blood
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