scholarly journals Bradykinin B2 Receptor Signaling Increases Glucose Uptake and Oxidation: Evidence and Open Questions

2020 ◽  
Vol 11 ◽  
Author(s):  
Marcos Fernandes Gregnani ◽  
Talita G. Hungaro ◽  
Leonardo Martins-Silva ◽  
Michael Bader ◽  
Ronaldo C. Araujo
Keyword(s):  
Glucose Uptake ◽  
Receptor Signaling ◽  
Bradykinin B2 Receptor ◽  
Open Questions

scholarly journals Potentiation of B2 receptor signaling by AltB2R, a newly identified alternative protein encoded in the human bradykinin B2 receptor gene

2021 ◽  
Vol 296 ◽  
pp. 100329
Author(s):  
Maxime Gagnon ◽  
Martin Savard ◽  
Jean-François Jacques ◽  
Ghassan Bkaily ◽  
Sameh Geha ◽  
...  
Keyword(s):  
Receptor Gene ◽  
Receptor Signaling ◽  
Bradykinin B2 Receptor ◽  
Alternative Protein

scholarly journals Mechanistic insight into how gonadotropin hormone receptor complexes direct signaling†

2019 ◽  
Vol 102 (4) ◽  
pp. 773-783
Author(s):  
Gillian P Johnson ◽  
Kim Carol Jonas
Keyword(s):  
Hormone Receptor ◽  
Future Research ◽  
Signal Pathways ◽  
Receptor Signaling ◽  
Female Reproduction ◽  
Differential Signal ◽  
Receptor Complexes ◽  
Open Questions ◽  
Future Research Directions ◽  
Pka Pathway

Abstract Gonadotropin hormones and their receptors play a central role in the control of male and female reproduction. In recent years, there has been growing evidence surrounding the complexity of gonadotropin hormone/receptor signaling, with it increasingly apparent that the Gαs/cAMP/PKA pathway is not the sole signaling pathway that confers their biological actions. Here we review recent literature on the different receptor–receptor, receptor–scaffold, and receptor–signaling molecule complexes formed and how these modulate and direct gonadotropin hormone-dependent intracellular signal activation. We will touch upon the more controversial issue of extragonadal expression of FSHR and the differential signal pathways activated in these tissues, and lastly, highlight the open questions surrounding the role these gonadotropin hormone receptor complexes and how this will shape future research directions.

scholarly journals P-LAP/IRAP-induced cell proliferation and glucose uptake in endometrial carcinoma cells via insulin receptor signaling

BMC Cancer ◽  
2007 ◽  
Vol 7 (1) ◽  
Author(s):  
Kiyosumi Shibata ◽  
Hiroaki Kajiyama ◽  
Kazuhiko Ino ◽  
Akihiro Nawa ◽  
Seiji Nomura ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Insulin Receptor ◽  
Endometrial Carcinoma ◽  
Glucose Uptake ◽  
Carcinoma Cells ◽  
Receptor Signaling ◽  
Insulin Receptor Signaling

scholarly journals Bradykinin potentiates insulin-stimulated glucose uptake and enhances insulin signal through the bradykinin B2 receptor in dog skeletal muscle and rat L6 myoblasts

1998 ◽  
pp. 344-352 ◽  
Author(s):  
T Miyata ◽  
T Taguchi ◽  
M Uehara ◽  
S Isami ◽  
H Kishikawa ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Receptor ◽  
Glucose Uptake ◽  
Dependent Manner ◽  
Glut4 Translocation ◽  
Binding Studies ◽  
Insulin Receptor Tyrosine Kinase ◽  
Peripheral Tissues ◽  
Bradykinin B2 Receptor ◽  
Increase Glucose Uptake

Previously we demonstrated that bradykinin infusion could increase glucose uptake into dog peripheral tissues, and that bradykinin could potentiate insulin-induced glucose uptake through glucose transporter 4 (GLUT4) translocation in dog adipocytes. However, skeletal muscle is the predominant tissue for insulin-mediated glucose disposal. The aim of this study was to determine how bradykinin affected insulin-stimulated glucose uptake in dog skeletal muscle and myotubes transformed from rat L6 myoblasts. The bradykinin receptor binding studies revealed that dog skeletal muscle and rat L6 myoblasts possessed significant numbers of bradykinin receptors (Kd = 88 and 76 pmol/l, Bmax = 82.5 and 20 fmol/mg protein respectively). An RT-PCR (reverse transcriptase-polymerase chain reaction) amplification showed mRNA specific for bradykinin B2 receptor in both cells. Bradykinin significantly increased 2-deoxyglucose uptake in isolated muscle and L6 myoblasts in the presence of insulin (10(-7) mol/l) in a dose-dependent manner, but not in the absence of insulin. Bradykinin also enhanced insulin-stimulated GLUT4 translocation, and insulin-induced phosphorylation of insulin receptor beta subunit and insulin receptor substrate-1 (IRS-1) without affecting the binding affinities or numbers of cell surface insulin receptors in both cells. It is concluded that bradykinin could potentiate the insulin-induced glucose uptake through GLUT4 translocation in dog skeletal muscle and rat L6 myoblasts. This effect could be explained by the potency of bradykinin to upregulate the insulin receptor tyrosine kinase activity which stimulates phosphorylation of IRS-1, followed by an increase in GLUT4 translocation.

scholarly journals Exercise training improves muscle insulin resistance but not insulin receptor signaling in obese Zucker rats

2002 ◽  
Vol 92 (2) ◽  
pp. 736-744 ◽  
Author(s):  
Christine Y. Christ ◽  
Desmond Hunt ◽  
Joe Hancock ◽  
Rebeca Garcia-Macedo ◽  
Lawrence J. Mandarino ◽  
...  
Keyword(s):  
Exercise Training ◽  
Insulin Receptor ◽  
Glucose Uptake ◽  
Exercise Bout ◽  
Pi3 Kinase ◽  
Serine Phosphorylation ◽  
Zucker Rats ◽  
Receptor Signaling ◽  
Insulin Receptor Signaling ◽  
Obese Zucker Rats

Exercise training improves skeletal muscle insulin sensitivity in the obese Zucker rat. The purpose of this study was to investigate whether the improvement in insulin action in response to exercise training is associated with enhanced insulin receptor signaling. Obese Zucker rats were trained for 7 wk and studied by using the hindlimb-perfusion technique 24 h, 96 h, or 7 days after their last exercise training bout. Insulin-stimulated glucose uptake (traced with 2-deoxyglucose) was significantly reduced in untrained obese Zucker rats compared with lean controls (2.2 ± 0.17 vs. 5.4 ± 0.46 μmol · g−1 · h−1). Glucose uptake was normalized 24 h after the last exercise bout (4.9 ± 0.41 μmol · g−1 · h−1) and remained significantly elevated above the untrained obese Zucker rats for 7 days. However, exercise training did not increase insulin receptor or insulin receptor substrate-1 (IRS-1) tyrosine phosphorylation, phosphatidylinositol 3-kinase (PI3-kinase) activity associated with IRS-1 or tyrosine phosphorylated immunoprecipitates, or Akt serine phosphorylation. These results are consistent with the hypothesis that, in obese Zucker rats, adaptations occur during training that lead to improved insulin-stimulated muscle glucose uptake without affecting insulin receptor signaling through the PI3-kinase pathway.

scholarly journals The Bradykinin B2 Receptor Gene Is a Target of Angiotensin II Type 1 Receptor Signaling

2007 ◽  
Vol 18 (4) ◽  
pp. 1140-1149 ◽  
Author(s):  
Bing Shen ◽  
Lisa M. Harrison-Bernard ◽  
Andrew J. Fuller ◽  
Vanessa Vanderpool ◽  
Zubaida Saifudeen ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Receptor Gene ◽  
Receptor Signaling ◽  
Bradykinin B2 Receptor

scholarly journals Host Stromal Bradykinin B2 Receptor Signaling Facilitates Tumor-Associated Angiogenesis and Tumor Growth

2004 ◽  
Vol 64 (15) ◽  
pp. 5178-5185 ◽  
Author(s):  
Yasuhiro Ikeda ◽  
Izumi Hayashi ◽  
Emi Kamoshita ◽  
Akira Yamazaki ◽  
Hirahito Endo ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Receptor Signaling ◽  
Bradykinin B2 Receptor

scholarly journals Bradykinin B2 receptor signaling: Structural and functional characterization of the C-terminus

Biopolymers ◽  
2005 ◽  
Vol 80 (2-3) ◽  
pp. 367-373 ◽  
Author(s):  
Andrea Piserchio ◽  
Veronica Zelesky ◽  
Jun Yu ◽  
Linda Taylor ◽  
Peter Polgar ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Receptor Signaling ◽  
Bradykinin B2 Receptor ◽  
C Terminus

The angiotensin II type 1 receptor antagonist Losartan binds and activates bradykinin B2 receptor signaling

2011 ◽  
Vol 167 (1) ◽  
pp. 21-25 ◽  
Author(s):  
Marie Mi Bonde ◽  
Kristine Boisen Olsen ◽  
Niels Erikstrup ◽  
Tobias Speerschneider ◽  
Christina Lyngsø ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Receptor Antagonist ◽  
Receptor Signaling ◽  
Bradykinin B2 Receptor

scholarly journals Oleic Acid Stimulates Glucose Uptake Into Adipocytes by Enhancing Insulin Receptor Signaling

2014 ◽  
Vol 126 (4) ◽  
pp. 337-343 ◽  
Author(s):  
Ayako Tsuchiya ◽  
Hisao Nagaya ◽  
Takeshi Kanno ◽  
Tomoyuki Nishizaki
Keyword(s):  
Oleic Acid ◽  
Insulin Receptor ◽  
Glucose Uptake ◽  
Receptor Signaling ◽  
Insulin Receptor Signaling
Sign in / Sign up

Export Citation Format

Share Document