scholarly journals Oleic Acid Stimulates Glucose Uptake Into Adipocytes by Enhancing Insulin Receptor Signaling

2014 ◽  
Vol 126 (4) ◽  
pp. 337-343 ◽  
Author(s):  
Ayako Tsuchiya ◽  
Hisao Nagaya ◽  
Takeshi Kanno ◽  
Tomoyuki Nishizaki
Keyword(s):  
Oleic Acid ◽  
Insulin Receptor ◽  
Glucose Uptake ◽  
Receptor Signaling ◽  
Insulin Receptor Signaling

scholarly journals P-LAP/IRAP-induced cell proliferation and glucose uptake in endometrial carcinoma cells via insulin receptor signaling

BMC Cancer ◽  
2007 ◽  
Vol 7 (1) ◽  
Author(s):  
Kiyosumi Shibata ◽  
Hiroaki Kajiyama ◽  
Kazuhiko Ino ◽  
Akihiro Nawa ◽  
Seiji Nomura ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Insulin Receptor ◽  
Endometrial Carcinoma ◽  
Glucose Uptake ◽  
Carcinoma Cells ◽  
Receptor Signaling ◽  
Insulin Receptor Signaling

scholarly journals Exercise training improves muscle insulin resistance but not insulin receptor signaling in obese Zucker rats

2002 ◽  
Vol 92 (2) ◽  
pp. 736-744 ◽  
Author(s):  
Christine Y. Christ ◽  
Desmond Hunt ◽  
Joe Hancock ◽  
Rebeca Garcia-Macedo ◽  
Lawrence J. Mandarino ◽  
...  
Keyword(s):  
Exercise Training ◽  
Insulin Receptor ◽  
Glucose Uptake ◽  
Exercise Bout ◽  
Pi3 Kinase ◽  
Serine Phosphorylation ◽  
Zucker Rats ◽  
Receptor Signaling ◽  
Insulin Receptor Signaling ◽  
Obese Zucker Rats

Exercise training improves skeletal muscle insulin sensitivity in the obese Zucker rat. The purpose of this study was to investigate whether the improvement in insulin action in response to exercise training is associated with enhanced insulin receptor signaling. Obese Zucker rats were trained for 7 wk and studied by using the hindlimb-perfusion technique 24 h, 96 h, or 7 days after their last exercise training bout. Insulin-stimulated glucose uptake (traced with 2-deoxyglucose) was significantly reduced in untrained obese Zucker rats compared with lean controls (2.2 ± 0.17 vs. 5.4 ± 0.46 μmol · g−1 · h−1). Glucose uptake was normalized 24 h after the last exercise bout (4.9 ± 0.41 μmol · g−1 · h−1) and remained significantly elevated above the untrained obese Zucker rats for 7 days. However, exercise training did not increase insulin receptor or insulin receptor substrate-1 (IRS-1) tyrosine phosphorylation, phosphatidylinositol 3-kinase (PI3-kinase) activity associated with IRS-1 or tyrosine phosphorylated immunoprecipitates, or Akt serine phosphorylation. These results are consistent with the hypothesis that, in obese Zucker rats, adaptations occur during training that lead to improved insulin-stimulated muscle glucose uptake without affecting insulin receptor signaling through the PI3-kinase pathway.

scholarly journals Glucose Regulates Foxo1 Through Insulin Receptor Signaling in the Pancreatic Islet  -cell

Diabetes ◽  
2006 ◽  
Vol 55 (6) ◽  
pp. 1581-1591 ◽  
Author(s):  
S. C. Martinez ◽  
C. Cras-Meneur ◽  
E. Bernal-Mizrachi ◽  
M. A. Permutt
Keyword(s):  
Insulin Receptor ◽  
Pancreatic Islet ◽  
Islet Cell ◽  
Receptor Signaling ◽  
Pancreatic Islet Cell ◽  
Insulin Receptor Signaling

Abstract PO-056: Insulin receptor signaling in pancreatic acinar cells contributes to pancreatic cancer development

2021 ◽  
Author(s):  
Anni M. Y. Zhang ◽  
Jenny C. C. Yang ◽  
Twan J. J. de Winter ◽  
David F. Schaeffer ◽  
Janel L. Kopp ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Insulin Receptor ◽  
Acinar Cells ◽  
Cancer Development ◽  
Pancreatic Acinar Cells ◽  
Receptor Signaling ◽  
Insulin Receptor Signaling

scholarly journals Molecular elevation of insulin receptor signaling improves memory recall in aged Fischer 344 rats

Aging Cell ◽  
2020 ◽  
Vol 19 (10) ◽  
Author(s):  
Hilaree N. Frazier ◽  
Katie L. Anderson ◽  
Adam O. Ghoweri ◽  
Ruei-Lung Lin ◽  
Tara R. Hawkinson ◽  
...  
Keyword(s):  
Insulin Receptor ◽  
Memory Recall ◽  
Receptor Signaling ◽  
Fischer 344 Rats ◽  
Fischer 344 ◽  
Insulin Receptor Signaling

scholarly journals Glucose and amino acid metabolism in mice depend mutually on glucagon and insulin receptor signaling

2019 ◽  
Vol 316 (4) ◽  
pp. E660-E673 ◽  
Author(s):  
Katrine D. Galsgaard ◽  
Marie Winther-Sørensen ◽  
Jens Pedersen ◽  
Sasha A. S. Kjeldsen ◽  
Mette M. Rosenkilde ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Insulin Receptor ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Receptor Signaling ◽  
Cell Secretion ◽  
Glucagon Receptor ◽  
Insulin Receptor Signaling ◽  
Glucagon And Insulin

Glucagon and insulin are important regulators of blood glucose. The importance of insulin receptor signaling for alpha-cell secretion and of glucagon receptor signaling for beta-cell secretion is widely discussed and of clinical interest. Amino acids are powerful secretagogues for both hormones, and glucagon controls amino acid metabolism through ureagenesis. The role of insulin in amino acid metabolism is less clear. Female C57BL/6JRj mice received an insulin receptor antagonist (IRA) (S961; 30 nmol/kg), a glucagon receptor antagonist (GRA) (25-2648; 100 mg/kg), or both GRA and IRA (GRA + IRA) 3 h before intravenous administration of similar volumes of saline, glucose (0.5 g/kg), or amino acids (1 µmol/g) while anesthetized with isoflurane. IRA caused basal hyperglycemia, hyperinsulinemia, and hyperglucagonemia. Unexpectedly, IRA lowered basal plasma concentrations of amino acids, whereas GRA increased amino acids, lowered glycemia, and increased glucagon but did not influence insulin concentrations. After administration of GRA + IRA, insulin secretion was significantly reduced compared with IRA administration alone. Blood glucose responses to a glucose and amino acid challenge were similar after vehicle and GRA + IRA administration but greater after IRA and lower after GRA. Anesthesia may have influenced the results, which otherwise strongly suggest that both hormones are essential for the maintenance of glucose homeostasis and that the secretion of both is regulated by powerful negative feedback mechanisms. In addition, insulin limits glucagon secretion, while endogenous glucagon stimulates insulin secretion, revealed during lack of insulin autocrine feedback. Finally, glucagon receptor signaling seems to be of greater importance for amino acid metabolism than insulin receptor signaling.

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