scholarly journals Eupafolin Suppresses Esophagus Cancer Growth by Targeting T-LAK Cell-Originated Protein Kinase

2019 ◽  
Vol 10 ◽  
Author(s):  
Xiaoming Fan ◽  
Junyan Tao ◽  
Xin Cai ◽  
Mangaladoss Fredimoses ◽  
Junzi Wu ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Cancer Growth ◽  
Esophagus Cancer ◽  
Lak Cell

scholarly journals Baicalin suppresses lung cancer growth by targeting PDZ-binding kinase/T-LAK cell-originated protein kinase

2019 ◽  
Vol 39 (4) ◽  
Author(s):  
Xin Diao ◽  
Danfen Yang ◽  
Yu Chen ◽  
Wentian Liu
Keyword(s):  
Lung Cancer ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Ex Vivo ◽  
Lung Cancer Cells ◽  
Cancer Growth ◽  
Downstream Signaling ◽  
Lak Cell

AbstractBaicalin is the main bioactive component extracted from the traditional Chinese medicine Baical Skullcap Root, and its anti-tumor activity has been studied in previous studies. PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK), a serine/threonine protein kinase, is highly expressed in many cancer cells and stimulates the tumorigenic properties, and so, it is a pivotal target for agent to cure cancers. We reported for the first time that baicalin suppressed PBK/TOPK activities by directly binding with PBK/TOPK in vitro and in vivo. Ex vivo studies showed that baicalin suppressed PBK/TOPK activity in JB6 Cl41 cells and H441 lung cancer cells. Moreover, knockdown of PBK/TOPK in H441 cells decreased their sensitivity to baicalin. In vivo study indicated that injection of baicalin in H441 tumor-bearing mice effectively suppressed cancer growth. The PBK/TOPK downstream signaling molecules Histone H3 and ERK2 in tumor tissues were also decreased after baicalin treatment. Taken together, baicalin can inhibit proliferation of lung cancer cells as a PBK/TOPK inhibitor both in vitro and in vivo.

scholarly journals T-LAK Cell-originated Protein Kinase (TOPK) Phosphorylation of Prx1 at Ser-32 Prevents UVB-induced Apoptosis in RPMI7951 Melanoma Cells through the Regulation of Prx1 Peroxidase Activity

2010 ◽  
Vol 285 (38) ◽  
pp. 29138-29146 ◽  
Author(s):  
Tatyana A. Zykova ◽  
Feng Zhu ◽  
Tatyana I. Vakorina ◽  
Jishuai Zhang ◽  
Lee Ann Higgins ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Peroxidase Activity ◽  
Melanoma Cells ◽  
Lak Cell ◽  
Induced Apoptosis

T-LAK Cell-Originated Protein Kinase (TOPK) as a Prognostic Factor and a Potential Therapeutic Target in Ovarian Cancer

2016 ◽  
Vol 22 (24) ◽  
pp. 6110-6117 ◽  
Author(s):  
Yuji Ikeda ◽  
Jae-Hyun Park ◽  
Takashi Miyamoto ◽  
Naofumi Takamatsu ◽  
Taigo Kato ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Protein Kinase ◽  
Prognostic Factor ◽  
Therapeutic Target ◽  
Potential Therapeutic Target ◽  
Lak Cell

scholarly journals A Novel Small-Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth In vitro and In vivo

2010 ◽  
Vol 9 (5) ◽  
pp. 1136-1146 ◽  
Author(s):  
Kuzhuvelil B. Harikumar ◽  
Ajaikumar B. Kunnumakkara ◽  
Nobuo Ochi ◽  
Zhimin Tong ◽  
Amit Deorukhkar ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Protein Kinase ◽  
Small Molecule ◽  
Small Molecule Inhibitor ◽  
Cancer Growth ◽  
Protein Kinase D ◽  
Molecule Inhibitor

scholarly journals Protein kinase D inhibitor CRT0066101 suppresses bladder cancer growth in vitro and xenografts via blockade of the cell cycle at G2/M

2017 ◽  
Vol 75 (5) ◽  
pp. 939-963 ◽  
Author(s):  
Qingdi Quentin Li ◽  
Iawen Hsu ◽  
Thomas Sanford ◽  
Reema Railkar ◽  
Navin Balaji ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Bladder Cancer ◽  
Protein Kinase ◽  
Cancer Growth ◽  
Protein Kinase D

Critical roles of T-LAK cell-originated protein kinase in cytokinesis

2010 ◽  
Vol 101 (2) ◽  
pp. 403-411 ◽  
Author(s):  
Jae-Hyun Park ◽  
Toshihiko Nishidate ◽  
Yusuke Nakamura ◽  
Toyomasa Katagiri
Keyword(s):  
Protein Kinase ◽  
Lak Cell
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