scholarly journals Nrf2 Suppression Delays Diabetic Wound Healing Through Sustained Oxidative Stress and Inflammation

2019 ◽  
Vol 10 ◽  
Author(s):  
Min Li ◽  
Haibing Yu ◽  
Haiyan Pan ◽  
Xueqing Zhou ◽  
Qiongfang Ruan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wound Healing ◽  
Diabetic Wound ◽  
Diabetic Wound Healing

scholarly journals The Role of Oxidative Stress and Antioxidants in Diabetic Wound Healing

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Liling Deng ◽  
Chenzhen Du ◽  
Peiyang Song ◽  
Tianyi Chen ◽  
Shunli Rui ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wound Healing ◽  
Vital Role ◽  
The Body ◽  
Diabetic Wound ◽  
Cell Tissue ◽  
Poor Nutritional Status ◽  
Diabetic Wound Healing ◽  
Dietary Bioactive Compounds

Foot ulcers are one of the most common and severe complication of diabetes mellitus with significant resultant morbidity and mortality. Multiple factors impair wound healing include skin injury, diabetic neuropathy, ischemia, infection, inadequate glycemic control, poor nutritional status, and severe morbidity. It is currently believed that oxidative stress plays a vital role in diabetic wound healing. An imbalance of free radicals and antioxidants in the body results in overproduction of reactive oxygen species which lead to cell, tissue damage, and delayed wound healing. Therefore, decreasing ROS levels through antioxidative systems may reduce oxidative stress-induced damage to improve healing. In this context, we provide an update on the role of oxidative stress and antioxidants in diabetic wound healing through following four perspectives. We then discuss several therapeutic strategies especially dietary bioactive compounds by targeting oxidative stress to improve wounds healing.

scholarly journals ERβ Accelerates Diabetic Wound Healing by Ameliorating Hyperglycemia-Induced Persistent Oxidative Stress

2019 ◽  
Vol 10 ◽  
Author(s):  
Xueqing Zhou ◽  
Min Li ◽  
Meifang Xiao ◽  
Qiongfang Ruan ◽  
Zhigang Chu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wound Healing ◽  
Diabetic Wound ◽  
Diabetic Wound Healing

An aligned porous electrospun fibrous scaffold with embedded asiatic acid for accelerating diabetic wound healing

2019 ◽  
Vol 7 (40) ◽  
pp. 6125-6138 ◽  
Author(s):  
Yiming Han ◽  
Yuqi Jiang ◽  
You Li ◽  
Minna Wang ◽  
Tingting Fan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wound Healing ◽  
Lactic Acid ◽  
Asiatic Acid ◽  
Diabetic Wound ◽  
Fibrous Scaffold ◽  
Diabetic Wound Healing ◽  
High Oxidative Stress ◽  
Porous Poly

An asiatic acid (AA)-embedded aligned porous poly (l-lactic acid) electrospun fibrous scaffold was successfully prepared for significantly relieving the high oxidative stress in the diabetic wound bed and thereby accelerating diabetic wound healing.

scholarly journals Neuroprotectin/protectin D1: endogenous biosynthesis and actions on diabetic macrophages in promoting wound healing and innervation impaired by diabetes

2014 ◽  
Vol 307 (11) ◽  
pp. C1058-C1067 ◽  
Author(s):  
Song Hong ◽  
Haibin Tian ◽  
Yan Lu ◽  
James Monroe Laborde ◽  
Filipe A. Muhale ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wound Healing ◽  
Chronic Inflammation ◽  
Time Course ◽  
Skin Wound ◽  
Diabetic Wound ◽  
Diabetic Mice ◽  
Diabetic Wound Healing ◽  
Diabetic Wounds ◽  
And Oxidative Stress

Dysfunction of macrophages (MΦs) in diabetic wounds impairs the healing. MΦs produce anti-inflammatory and pro-resolving neuroprotectin/protectin D1 (NPD1/PD1, 10 R,17 S-dihydroxy-docosa-4 Z,7 Z,11 E,13 E,15 Z,19 Z-hexaenoic acid); however, little is known about endogenous NPD1 biosynthesis by MΦs and the actions of NPD1 on diabetic MΦ functions in diabetic wound healing. We used an excisional skin wound model of diabetic mice, MΦ depletion, MΦs isolated from diabetic mice, and mass spectrometry-based targeted lipidomics to study the time course progression of NPD1 levels in wounds, the roles of MΦs in NPD1 biosynthesis, and NPD1 action on diabetic MΦ inflammatory activities. We also investigated the healing, innervation, chronic inflammation, and oxidative stress in diabetic wounds treated with NPD1 or NPD1-modulated MΦs from diabetic mice. Injury induced endogenous NPD1 biosynthesis in wounds, but diabetes impeded NPD1 formation. NPD1 was mainly produced by MΦs. NPD1 enhanced wound healing and innervation in diabetic mice and promoted MΦs functions that accelerated these processes. The underlying mechanisms for these actions of NPD1 or NPD1-modulated MΦs involved 1) attenuating MΦ inflammatory activities and chronic inflammation and oxidative stress after acute inflammation in diabetic wound, and 2) increasing MΦ production of IL10 and hepatocyte growth factor. Taken together, NPD1 appears to be a MΦs-produced factor that accelerates diabetic wound healing and promotes MΦ pro-healing functions in diabetic wounds. Decreased NPD1 production in diabetic wound is associated with impaired healing. This study identifies a new molecular target that might be useful in development of more effective therapeutics based on NPD1 and syngeneic diabetic MΦs for treatment of diabetic wounds.

scholarly journals Antioxidant Therapy and Antioxidant-Related Bionanomaterials in Diabetic Wound Healing

2021 ◽  
Vol 9 ◽  
Author(s):  
Wenqian Zhang ◽  
Lang Chen ◽  
Yuan Xiong ◽  
Adriana C. Panayi ◽  
Abudula Abududilibaier ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wound Healing ◽  
Healing Process ◽  
Polyol Pathway ◽  
Antioxidant Therapy ◽  
Wound Healing Process ◽  
Diabetic Wound ◽  
Recurrence Rates ◽  
Key Factor ◽  
Diabetic Wound Healing

Ulcers are a lower-extremity complication of diabetes with high recurrence rates. Oxidative stress has been identified as a key factor in impaired diabetic wound healing. Hyperglycemia induces an accumulation of intracellular reactive oxygen species (ROS) and advanced glycation end products, activation of intracellular metabolic pathways, such as the polyol pathway, and PKC signaling leading to suppression of antioxidant enzymes and compounds. Excessive and uncontrolled oxidative stress impairs the function of cells involved in the wound healing process, resulting in chronic non-healing wounds. Given the central role of oxidative stress in the pathology of diabetic ulcers, we performed a comprehensive review on the mechanism of oxidative stress in diabetic wound healing, focusing on the progress of antioxidant therapeutics. We summarize the antioxidant therapies proposed in the past 5 years for use in diabetic wound healing, including Nrf2- and NFκB-pathway-related antioxidant therapy, vitamins, enzymes, hormones, medicinal plants, and biological materials.

The diabetic wound healing effect of a two-herb formula and its mechanisms of action

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
CBS Lau ◽  
VKM Lau ◽  
CL Liu ◽  
PKK Lai ◽  
JCW Tam ◽  
...  
Keyword(s):  
Wound Healing ◽  
Mechanisms Of Action ◽  
Diabetic Wound ◽  
Healing Effect ◽  
Diabetic Wound Healing ◽  
Wound Healing Effect
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