scholarly journals The Role of Oxidative Stress and Antioxidants in Diabetic Wound Healing

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Liling Deng ◽  
Chenzhen Du ◽  
Peiyang Song ◽  
Tianyi Chen ◽  
Shunli Rui ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wound Healing ◽  
Vital Role ◽  
The Body ◽  
Diabetic Wound ◽  
Cell Tissue ◽  
Poor Nutritional Status ◽  
Diabetic Wound Healing ◽  
Dietary Bioactive Compounds

Foot ulcers are one of the most common and severe complication of diabetes mellitus with significant resultant morbidity and mortality. Multiple factors impair wound healing include skin injury, diabetic neuropathy, ischemia, infection, inadequate glycemic control, poor nutritional status, and severe morbidity. It is currently believed that oxidative stress plays a vital role in diabetic wound healing. An imbalance of free radicals and antioxidants in the body results in overproduction of reactive oxygen species which lead to cell, tissue damage, and delayed wound healing. Therefore, decreasing ROS levels through antioxidative systems may reduce oxidative stress-induced damage to improve healing. In this context, we provide an update on the role of oxidative stress and antioxidants in diabetic wound healing through following four perspectives. We then discuss several therapeutic strategies especially dietary bioactive compounds by targeting oxidative stress to improve wounds healing.

scholarly journals Therapeutic Role of Nitric Oxide in Diabetic Wound Healing: A Systematic Review

2021 ◽  
pp. 68-80
Author(s):  
Mayur Meghashyam Chavhan ◽  
Ranjit Vinayak Gadhave ◽  
Yogita Sachin Ozarde ◽  
Ganesh Bhaurao Choudhari
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Bacterial Infections ◽  
The Body ◽  
Low Level Laser Therapy ◽  
Diabetic Patients ◽  
Diabetic Wound ◽  
Impaired Wound Healing ◽  
Diabetic Wound Healing

Post injury, healing of wound is essential for recovery of uprightness of the body, which is one of the complex, continuous and unanticipated chains of events in case of diabetic patients. Nitric oxide represents a potential wound therapeutic agent due to its ability to regulate inflammation and eradicate bacterial infections. Impaired wound healing is a prominent diabetic complication which may lead to amputations also. In addition to modern medicines we can use nitric oxide therapy prominently for diabetic wound healing. Prominent and proven role of nitric oxide as well as conventional materials (like metformin and hydrogen sulphide, whey proteins, acidified nitrile etc), therapies (like low level laser therapy, hyperbaric oxygen therapy etc) and techniques (like in vivo implants with biosensors) can be taken into consideration. Many plant extracts showed promising results for wound healing activity by increasing nitric oxide levels. Use of modern technologies such as implant with biosensor and technique like sonic head hog gene are available for diabetic wound healing using Nitric oxide. In this review, an attempt has been made to compile comprehensive updated information of role of nitric oxide in diabetic wound healing, which may be exploited by focusing more on development of effective strategies to treat diabetes-associated wound.

scholarly journals Abnormal Cell Responses and Role of TNF-αin Impaired Diabetic Wound Healing

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Fanxing Xu ◽  
Chenying Zhang ◽  
Dana T. Graves
Keyword(s):  
Wound Healing ◽  
Macrophage Polarization ◽  
Diabetic Wound ◽  
Major Health Problem ◽  
Abnormal Cell ◽  
Fibroblast Migration ◽  
Cell Responses ◽  
Impaired Healing ◽  
Diabetic Wound Healing

Impaired diabetic wound healing constitutes a major health problem. The impaired healing is caused by complex factors such as abnormal keratinocyte and fibroblast migration, proliferation, differentiation, and apoptosis, abnormal macrophage polarization, impaired recruitment of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs), and decreased vascularization. Diabetes-enhanced and prolonged expression of TNF-αalso contributes to impaired healing. In this paper, we discuss the abnormal cell responses in diabetic wound healing and the contribution of TNF-α.

scholarly journals An Essential Role of NRF2 in Diabetic Wound Healing

Diabetes ◽  
2015 ◽  
Vol 65 (3) ◽  
pp. 780-793 ◽  
Author(s):  
Min Long ◽  
Montserrat Rojo de la Vega ◽  
Qing Wen ◽  
Manish Bharara ◽  
Tao Jiang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Essential Role ◽  
Diabetic Wound ◽  
Diabetic Wound Healing

scholarly journals MicroRNA signature in diabetic wound healing: promotive role of miR-21 in fibroblast migration

2011 ◽  
Vol 9 (4) ◽  
pp. 355-361 ◽  
Author(s):  
R Madhyastha ◽  
H Madhyastha ◽  
Y Nakajima ◽  
S Omura ◽  
M Maruyama
Keyword(s):  
Wound Healing ◽  
Diabetic Wound ◽  
Fibroblast Migration ◽  
Diabetic Wound Healing

scholarly journals The Role of Matrix Metalloproteinases in Diabetic Wound Healing in relation to Photobiomodulation

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Sandra Matabi Ayuk ◽  
Heidi Abrahamse ◽  
Nicolette Nadene Houreld
Keyword(s):  
Wound Healing ◽  
Matrix Metalloproteinases ◽  
Vascular Complications ◽  
Diabetic Patients ◽  
Main Function ◽  
Diabetic Wound ◽  
Impaired Wound Healing ◽  
Inflammatory Phase ◽  
Diabetic Wound Healing

The integration of several cellular responses initiates the process of wound healing. Matrix Metalloproteinases (MMPs) play an integral role in wound healing. Their main function is degradation, by removal of damaged extracellular matrix (ECM) during the inflammatory phase, breakdown of the capillary basement membrane for angiogenesis and cell migration during the proliferation phase, and contraction and remodelling of tissue in the remodelling phase. For effective healing to occur, all wounds require a certain amount of these enzymes, which on the contrary could be very damaging at high concentrations causing excessive degradation and impaired wound healing. The imbalance in MMPs may increase the chronicity of a wound, a familiar problem seen in diabetic patients. The association of diabetes with impaired wound healing and other vascular complications is a serious public health issue. These may eventually lead to chronic foot ulcers and amputation. Low intensity laser irradiation (LILI) or photobiomodulation (PBM) is known to stimulate several wound healing processes; however, its role in matrix proteins and diabetic wound healing has not been fully investigated. This review focuses on the role of MMPs in diabetic wound healing and their interaction in PBM.

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