scholarly journals Pathophysiological Mechanisms and Potential Therapeutic Targets in Intracerebral Hemorrhage

2019 ◽  
Vol 10 ◽  
Author(s):  
Zhiwei Shao ◽  
Sheng Tu ◽  
Anwen Shao
Keyword(s):  
Intracerebral Hemorrhage ◽  
Therapeutic Targets ◽  
Pathophysiological Mechanisms

Treatment of COVID-19: a review of current and prospective pharmacotherapies

2021 ◽  
pp. 1-9
Author(s):  
Eleanor Quek ◽  
Hasan Tahir ◽  
Poornima Kumar ◽  
Robert Hastings ◽  
Rajeev Jha
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Therapeutic Targets ◽  
Pathophysiological Mechanisms ◽  
Socioeconomic Consequences

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread and have grave health and socioeconomic consequences worldwide. Researchers have raced to understand the pathophysiological mechanisms underpinning the disease caused by SARS-CoV-2 so that effective therapeutic targets can be discovered. This review summarises the key pharmacotherapies that are being investigated for treatment of COVID-19, including antiviral, immunomodulator and anticoagulation strategies.

scholarly journals Inflammatory Cytokines, Immune Cells, and Organ Interactions in Heart Failure

2021 ◽  
Vol 12 ◽  
Author(s):  
Huihui Li ◽  
Chen Chen ◽  
Dao Wen Wang
Keyword(s):  
Heart Failure ◽  
Clinical Trials ◽  
Inflammatory Cytokines ◽  
Immune Cells ◽  
Inflammatory Responses ◽  
Therapeutic Targets ◽  
Pathophysiological Mechanisms

Despite mounting evidence demonstrating the significance of inflammation in the pathophysiological mechanisms of heart failure (HF), most large clinical trials that target the inflammatory responses in HF yielded neutral or even worsening outcomes. Further in-depth understanding about the roles of inflammation in the pathogenesis of HF is eagerly needed. This review summarizes cytokines, cardiac infiltrating immune cells, and extracardiac organs that orchestrate the complex inflammatory responses in HF and highlights emerging therapeutic targets.

Neuroinflammation Mediated by NLRP3 Inflammasome After Intracerebral Hemorrhage and Potential Therapeutic Targets

2020 ◽  
Vol 57 (12) ◽  
pp. 5130-5149
Author(s):  
Linglong Xiao ◽  
Huaping Zheng ◽  
Jing Li ◽  
Qinghua Wang ◽  
Haitao Sun
Keyword(s):  
Intracerebral Hemorrhage ◽  
Nlrp3 Inflammasome ◽  
Therapeutic Targets

scholarly journals WITHDRAWN: Mechanisms and potential therapeutic targets for intracerebral hemorrhage

2019 ◽  
Author(s):  
Wei Hua ◽  
Xiuli Yang ◽  
Xuemei Chen ◽  
Honglei Ren ◽  
Michael Hong ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Therapeutic Targets

scholarly journals Magnesium: Pathophysiological mechanisms and potential therapeutic roles in intracerebral hemorrhage

2019 ◽  
Vol 14 (7) ◽  
pp. 1116 ◽  
Author(s):  
AdamS Arthur ◽  
JasonJ Chang ◽  
Rocco Armonda ◽  
Nitin Goyal
Keyword(s):  
Intracerebral Hemorrhage ◽  
Pathophysiological Mechanisms

scholarly journals Atrial Fibrillation: Development Mechanisms, Approaches and Prospects of Therapy

2020 ◽  
Vol 16 (1) ◽  
pp. 118-125 ◽  
Author(s):  
O. V. Sapelnikov ◽  
A. A. Kulikov ◽  
D. I. Cherkashin ◽  
I. R. Grishin ◽  
O. A. Nikolaeva ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Therapeutic Targets ◽  
Dynamic Interaction ◽  
P Waves ◽  
Pathophysiological Mechanisms ◽  
Entire Process ◽  
Atrial Activation ◽  
Permanent Form

Atrial fibrillation (AF) is the most common arrhythmia. It is diagnosed in more than 33 million people worldwide and is the leading cause of hospitalization for arrhythmias. AF is characterized by fast and irregular atrial activation without discrete P-waves at a surface electrocardiography. AF pathophysiological mechanisms are very complex and include the dynamic interaction between arrhythmia substrate and triggers. Consequently, the clinical search for effective therapeutic targets should include the entire process of the onset and progression of the disease: from the first paroxysms to the development of a stable permanent form of AF.

scholarly journals Mechanisms and Therapeutic Targets of Depression After Intracerebral Hemorrhage

2018 ◽  
Vol 9 ◽  
Author(s):  
Yinan Wu ◽  
Liangliang Wang ◽  
Kaimin Hu ◽  
Chengcheng Yu ◽  
Yuanhan Zhu ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Therapeutic Targets

scholarly journals Oxidative Stress in Intracerebral Hemorrhage: Sources, Mechanisms, and Therapeutic Targets

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Xin Hu ◽  
Chuanyuan Tao ◽  
Qi Gan ◽  
Jun Zheng ◽  
Hao Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Brain Injury ◽  
Intracerebral Hemorrhage ◽  
Brain Damage ◽  
Molecular Mechanisms ◽  
Therapeutic Targets ◽  
Heme Iron ◽  
Mortality And Morbidity ◽  
Underlying Mechanisms ◽  
Damaging Effects

Intracerebral hemorrhage (ICH) is associated with the highest mortality and morbidity despite only constituting approximately 10–15% of all strokes. Complex underlying mechanisms consisting of cytotoxic, excitotoxic, and inflammatory effects of intraparenchymal blood are responsible for its highly damaging effects. Oxidative stress (OS) also plays an important role in brain injury after ICH but attracts less attention than other factors. Increasing evidence has demonstrated that the metabolite axis of hemoglobin-heme-iron is the key contributor to oxidative brain damage after ICH, although other factors, such as neuroinflammation and prooxidases, are involved. This review will discuss the sources, possible molecular mechanisms, and potential therapeutic targets of OS in ICH.

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