scholarly journals Corrigendum: A Multi-Mode Bioactive Agent Isolated From Ficus microcarpa L. Fill. With Therapeutic Potential for Type 2 Diabetes Mellitus

2019 ◽  
Vol 10 ◽  
Author(s):  
Nosheen Akhtar ◽  
Laila Jafri ◽  
Brian D. Green ◽  
Saima Kalsoom ◽  
Bushra Mirza
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Therapeutic Potential ◽  
Ficus Microcarpa ◽  
Multi Mode ◽  
Bioactive Agent

The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus

2011 ◽  
Vol 14 (2) ◽  
pp. 112-120 ◽  
Author(s):  
R. S. Kootte ◽  
A. Vrieze ◽  
F. Holleman ◽  
G. M. Dallinga-Thie ◽  
E. G. Zoetendal ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gut Microbiota ◽  
Therapeutic Potential

Influence of piperine and quercetin on antidiabetic potential of curcumin

2016 ◽  
Vol 13 (3) ◽  
Author(s):  
Ginpreet Kaur ◽  
Mihir Invally ◽  
Meena Chintamaneni
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Oral Administration ◽  
Therapeutic Agent ◽  
Therapeutic Potential ◽  
Diabetic Rats ◽  
Reduced Dose ◽  
Single Intraperitoneal Injection

Abstract: Curcumin is a nutraceutical obtained from the rhizomes of: The present study was targeted to explore the antidiabetic potential of combinatorial extract of curcumin with piperine and quercetin (CPQ) in streptozotocin- and nicotinamide-induced diabetic rats. Diabetes mellitus was induced by single intraperitoneal injection of streptozotocin (55 mg/kg) and nicotinamide (120 mg/kg: Oral administration of CPQ at the dose of 100 mg kg: Treatment with combinatorial extract of curcumin presented a significantly better therapeutic potential when compared with curcumin alone, which reveals that CPQ, with reduced dose of curcumin may serve as a therapeutic agent in the treatment of type 2 diabetes mellitus.

scholarly journals Free Radicals Scavenging Capacity, Antidiabetic and Antihypertensive Activities of Flavonoid-Rich Fractions from Leaves ofTrichilia emeticaandOpilia amentaceain an Animal Model of Type 2 Diabetes Mellitus

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Kiessoun Konaté ◽  
Kassi Yomalan ◽  
Oksana Sytar ◽  
Patrice Zerbo ◽  
Marian Brestic ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Animal Model ◽  
Type 2 Diabetes Mellitus ◽  
Therapeutic Potential ◽  
Radical Scavenging Activity ◽  
Radical Scavenging

Trichilia emeticaandOpilia amentaceatraditional Burkinabe medicinal plants were investigated to determine their therapeutic potential to inhibit key enzymes in carbohydrate metabolism, which has relevance to the management of type 2 diabetes.In vitroandin vivoantioxidant and antihypertensive potential and antilipidemia and antihyperglycemia activities in an animal model of type 2 diabetes mellitus have been studied. The antioxidant activity of the flavonoids from leaves ofTrichilia emeticaandOpilia amentaceahas been evaluated usingβ-carotene-linoleic acid system, 1,1-diphenyl-2-picrylhydrazyl inhibitory activity, chelation of iron (II) ions, and lipid peroxidation which showed more pronounced antioxidant capacities ofTrichilia emetica. Total cholesterol concentrations decreased in an animal model of type 2 diabetes mellitus under effects of flavonoid-rich fractions from leaves ofTrichilia emeticaandOpilia amentaceahas been observed. Extract of flavonoid-rich fractions fromTrichilia emeticashown maximum radical scavenging activity and possessed marked antiamylase activity which may be due to the presence of certain secondary metabolites. Suggested better antihyperglycemia, antilipidemia, and antihypertensive properties of flavonoid-rich fractions fromTrichilia emeticacompared to the extract ofOpilia amentaceaare demonstrating antidiabetic potential ofTrichilia emeticaas therapeutic targets for the management of type 2 diabetes.

scholarly journals Rice Bran Derived Bioactive Compounds Modulate Risk Factors of Cardiovascular Disease and Type 2 Diabetes Mellitus: An Updated Review

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2736 ◽  
Author(s):  
Nancy Saji ◽  
Nidhish Francis ◽  
Lachlan J. Schwarz ◽  
Christopher L. Blanchard ◽  
Abishek B. Santhakumar
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Type 2 Diabetes Mellitus ◽  
Chronic Diseases ◽  
Bioactive Compounds ◽  
Rice Bran ◽  
Therapeutic Potential

Cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) are two chronic diseases that have claimed more lives globally than any other disease. Dietary supplementation of functional foods containing bioactive compounds is recognised to result in improvements in free-radical-mediated oxidative stress. Emerging evidence indicates that bioactive compounds derived from rice bran (RB) have therapeutic potential against cellular oxidative stress. This review aims to describe the mechanistic pathways behind CVD and T2DM development and the therapeutic potential of polyphenols derived from RB against these chronic diseases.

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