scholarly journals Time-Course Effects of Acute Aflatoxin B1 Exposure on Hepatic Mitochondrial Lipids and Oxidative Stress in Rats

2019 ◽  
Vol 10 ◽  
Author(s):  
Oluwakemi A. Rotimi ◽  
Solomon O. Rotimi ◽  
Jaclyn M. Goodrich ◽  
Isaacson B. Adelani ◽  
Emmanuel Agbonihale ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Aflatoxin B1 ◽  
Time Course ◽  
Mitochondrial Lipids ◽  
And Oxidative Stress

Time course of skeletal muscle loss and oxidative stress in rats with walker 256 solid tumor

2010 ◽  
Vol 42 (6) ◽  
pp. 950-958 ◽  
Author(s):  
Flávia A. Guarnier ◽  
Alessandra L. Cecchini ◽  
Andréia A. Suzukawa ◽  
Ana Leticia G.C. Maragno ◽  
Andréa N.C. Simão ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Solid Tumor ◽  
Time Course ◽  
Muscle Loss ◽  
Skeletal Muscle Loss ◽  
Walker 256 ◽  
And Oxidative Stress

Effects of Amaranthus cruentus L. on aflatoxin B1- and oxidative stress-induced DNA damage in human liver (HepG2) cells

2018 ◽  
Vol 26 ◽  
pp. 42-48 ◽  
Author(s):  
Grace A. Odongo ◽  
Nina Schlotz ◽  
Susanne Baldermann ◽  
Susanne Neugart ◽  
Benard Ngwene ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Aflatoxin B1 ◽  
Hepg2 Cells ◽  
Human Liver ◽  
Amaranthus Cruentus ◽  
And Oxidative Stress

Time Course of Cardiac Function and Oxidative Stress Induced by an Acute Bout of Exercise

2006 ◽  
Vol 38 (Supplement) ◽  
pp. S419
Author(s):  
Chia-Ying Lien ◽  
Karen Y. Wonders ◽  
David S. Hydock ◽  
Carole M. Schneider ◽  
Reid Hayward ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cardiac Function ◽  
Time Course ◽  
Acute Bout ◽  
And Oxidative Stress

Time course of the inflammatory and oxidative stress response to pulmonary infection in mice

2012 ◽  
Vol 38 (3) ◽  
pp. 157-163 ◽  
Author(s):  
Matthias Lange ◽  
Yoshimitsu Nakano ◽  
Daniel L. Traber ◽  
Atsumori Hamahata ◽  
Lillian D. Traber ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Time Course ◽  
Pulmonary Infection ◽  
Oxidative Stress Response ◽  
And Oxidative Stress

Time course of heme oxygenase-1 and oxidative stress after experimental intracerebral hemorrhage

2010 ◽  
Vol 153 (2) ◽  
pp. 319-325 ◽  
Author(s):  
Gaiqing Wang ◽  
Qidong Yang ◽  
Guanglai Li ◽  
Li Wang ◽  
Weimin Hu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intracerebral Hemorrhage ◽  
Heme Oxygenase ◽  
Time Course ◽  
Heme Oxygenase 1 ◽  
And Oxidative Stress

Bacillus amyloliquefaciens B10 can alleviate liver apoptosis and oxidative stress induced by aflatoxin B1

2021 ◽  
pp. 112124
Author(s):  
Xiaotong Li ◽  
Zhiming Lv ◽  
Jia Chen ◽  
Eugenie Nepovimova ◽  
Miao Long ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Aflatoxin B1 ◽  
Bacillus Amyloliquefaciens ◽  
And Oxidative Stress

Acute brain inflammation, white matter oxidative stress, and myelin deficiency in a model of neonatal intraventricular hemorrhage

2020 ◽  
Vol 26 (6) ◽  
pp. 613-623 ◽  
Author(s):  
Danielle S. Goulding ◽  
R. Caleb Vogel ◽  
John C. Gensel ◽  
Josh M. Morganti ◽  
Arnold J. Stromberg ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Brain Injury ◽  
White Matter ◽  
Rat Model ◽  
Intraventricular Hemorrhage ◽  
Time Course ◽  
Brain Inflammation ◽  
Current Therapy ◽  
Posthemorrhagic Hydrocephalus ◽  
And Oxidative Stress

OBJECTIVENeonatal intraventricular hemorrhage (IVH) leads to posthemorrhagic hydrocephalus (PHH), brain injury, and long-term disability. Current therapy for IVH is based on treating PHH but does not address the underlying brain injury. In order to develop pharmacological treatment for IVH, there must be a better understanding of the underlying pathology of this disease. This study was designed to determine the time course of the acute inflammation and oxidative stress that may underlie the progressive pathology of IVH. The authors sought to understand the temporal relationships among inflammation, oxidative stress, and white matter pathology in a rat model of IVH.METHODSA rat model of IVH consisting of hemoglobin injection into the lateral ventricle was used. Tissue was analyzed via biochemical and histological methods to map the spatiotemporal distribution of innate immune activation and oxidative stress. White matter was quantified using both immunohistochemistry and Western blot for myelin basic protein (MBP) in the corpus callosum.RESULTSIVH led to acute induction of inflammatory cytokines, followed by oxidative stress. Oxidative stress was concentrated in white matter, adjacent to the lateral ventricles. Animals with IVH initially gained weight at a lower rate than control animals and had larger ventricles and less MBP than control animals.CONCLUSIONSExperimental IVH induces global inflammation throughout the brain and oxidative stress concentrated in the white matter. Both of these phenomena occur early after IVH. This has implications for human neonates with immature white matter that is exquisitely sensitive to inflammation and oxidative stress. Antiinflammatory or antioxidant therapy for IVH may need to be initiated early in order to protect developing white matter.

scholarly journals A mitohormetic response to pro-oxidant exposure in the house mouse

2018 ◽  
Vol 314 (1) ◽  
pp. R122-R134 ◽  
Author(s):  
Yufeng Zhang ◽  
Frances Humes ◽  
Gregory Almond ◽  
Andreas N. Kavazis ◽  
Wendy R. Hood
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Time Course ◽  
Specific Response ◽  
Enzymatic Antioxidants ◽  
Stress Studies ◽  
Skeletal Muscle Mitochondria ◽  
Course Changes ◽  
X Irradiation ◽  
And Oxidative Stress

Mitochondria are hypothesized to display a biphasic response to reactive oxygen species (ROS) exposure. In this study, we evaluated the time course changes in mitochondrial performance and oxidative stress in house mice following X-irradiation. Forty-eight mice were equally divided among six groups, including a nonirradiated control and five experimental groups that varied in time between X-ray exposure and euthanasia (1 h and 1, 4, 7, and 10 days after X-irradiation). We measured parameters associated with mitochondrial respiratory function and ROS emission from isolated liver and skeletal muscle mitochondria and levels of oxidative damage and antioxidants in liver, skeletal muscle, and heart tissues. Mitochondrial function dropped initially after X-irradiation but recovered quickly and was elevated 10 days after the exposure. Hydrogen peroxide production, lipid peroxidation, and protein carbonylation showed inverse U-shaped curves, with levels returning to control or lower than control, 10 days after X-irradiation. Enzymatic antioxidants and markers for mitochondrial biogenesis exhibited a tissue-specific response after irradiation. These data provide the first chronological description of the mitohormetic response after a mild dose of irradiation and highlight the protective response that cells display to ROS exposure. This study also provides valuable information and application for future mitochondrial and oxidative stress studies in numerous physiological settings.

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