scholarly journals Proteomic Analysis Provides Insights Into the Therapeutic Effect of GU-BEN-FANG-XIAO Decoction on a Persistent Asthmatic Mouse Model

2019 ◽  
Vol 10 ◽  
Author(s):  
Li-wei Liu ◽  
Qiong-qiong Xing ◽  
Xia Zhao ◽  
Min Tan ◽  
Yuan Lu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Therapeutic Effect ◽  
Proteomic Analysis

Therapeutic Effect of Kakkonto in a Mouse Model of Food Allergy with Gastrointestinal Symptoms

2009 ◽  
Vol 148 (3) ◽  
pp. 175-185 ◽  
Author(s):  
Takeshi Yamamoto ◽  
Kanae Fujiwara ◽  
Minako Yoshida ◽  
Natsuko Kageyama-Yahara ◽  
Hirofumi Kuramoto ◽  
...  
Keyword(s):  
Food Allergy ◽  
Mouse Model ◽  
Therapeutic Effect ◽  
Gastrointestinal Symptoms

scholarly journals PRKAR1B-AS2 Long Noncoding RNA Promotes Tumorigenesis, Survival, and Chemoresistance via the PI3K/AKT/mTOR Pathway

2021 ◽  
Vol 22 (4) ◽  
pp. 1882
Author(s):  
Abdelrahman M. Elsayed ◽  
Emine Bayraktar ◽  
Paola Amero ◽  
Salama A. Salama ◽  
Abdelaziz H. Abdelaziz ◽  
...  
Keyword(s):  
Mouse Model ◽  
Long Noncoding Rna ◽  
Proteomic Analysis ◽  
Noncoding Rna ◽  
Mtor Pathway ◽  
The Cancer Genome Atlas ◽  
Migration And Invasion ◽  
Physical Interaction ◽  
Cisplatin Sensitivity

Many long noncoding RNAs have been implicated in tumorigenesis and chemoresistance; however, the underlying mechanisms are not well understood. We investigated the role of PRKAR1B-AS2 long noncoding RNA in ovarian cancer (OC) and chemoresistance and identified potential downstream molecular circuitry underlying its action. Analysis of The Cancer Genome Atlas OC dataset, in vitro experiments, proteomic analysis, and a xenograft OC mouse model were implemented. Our findings indicated that overexpression of PRKAR1B-AS2 is negatively correlated with overall survival in OC patients. Furthermore, PRKAR1B-AS2 knockdown-attenuated proliferation, migration, and invasion of OC cells and ameliorated cisplatin and alpelisib resistance in vitro. In proteomic analysis, silencing PRKAR1B-AS2 markedly inhibited protein expression of PI3K-110α and abrogated the phosphorylation of PDK1, AKT, and mTOR, with no significant effect on PTEN. The RNA immunoprecipitation detected a physical interaction between PRKAR1B-AS2 and PI3K-110α. Moreover, PRKAR1B-AS2 knockdown by systemic administration of 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine nanoparticles loaded with PRKAR1B-AS2–specific small interfering RNA enhanced cisplatin sensitivity in a xenograft OC mouse model. In conclusion, PRKAR1B-AS2 promotes tumor growth and confers chemoresistance by modulating the PI3K/AKT/mTOR pathway. Thus, targeting PRKAR1B-AS2 may represent a novel therapeutic approach for the treatment of OC patients.

scholarly journals Proteomic analysis revealed the altered kidney protein profile of a Cyld knockout mouse model

2015 ◽  
Vol 14 (2) ◽  
pp. 5970-5978 ◽  
Author(s):  
Y. Zhao ◽  
Y. Zhang ◽  
H.B. Song ◽  
F. Wu ◽  
X.L. Wang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Proteomic Analysis ◽  
Knockout Mouse ◽  
Protein Profile ◽  
Knockout Mouse Model

scholarly journals Therapeutic Effect of Berberine on Huntington’s Disease Transgenic Mouse Model

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0134142 ◽  
Author(s):  
Wenxiao Jiang ◽  
Wenjie Wei ◽  
Marta A. Gaertig ◽  
Shihua Li ◽  
Xiao-Jiang Li
Keyword(s):  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Transgenic Mouse ◽  
Therapeutic Effect ◽  
Transgenic Mouse Model

Proteomic analysis of the brain tissues from a transgenic mouse model of amyloid β oligomers

2012 ◽  
Vol 61 (3) ◽  
pp. 347-355 ◽  
Author(s):  
Masaoki Takano ◽  
Kouji Maekura ◽  
Mieko Otani ◽  
Keiji Sano ◽  
Tooru Nakamura-Hirota ◽  
...  
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
Proteomic Analysis ◽  
Amyloid Β ◽  
Transgenic Mouse Model ◽  
The Brain ◽  
Brain Tissues

scholarly journals High-Throughput LC–MS/MS Proteomic Analysis of a Mouse Model of Mesiotemporal Lobe Epilepsy Predicts Microglial Activation Underlying Disease Development

2016 ◽  
Vol 15 (5) ◽  
pp. 1546-1562 ◽  
Author(s):  
Vasiliki Bitsika ◽  
Venceslas Duveau ◽  
Julia Simon-Areces ◽  
William Mullen ◽  
Corinne Roucard ◽  
...  
Keyword(s):  
Mouse Model ◽  
High Throughput ◽  
Proteomic Analysis ◽  
Microglial Activation ◽  
Underlying Disease ◽  
Disease Development

The therapeutic effect of dendritic cells expressing indoleamine 2,3-dioxygenase (IDO) on an IgA nephropathy mouse model

2020 ◽  
Vol 52 (2) ◽  
pp. 399-407 ◽  
Author(s):  
Kanghan Liu ◽  
Yiya Yang ◽  
Yinyin Chen ◽  
Shiyao Li ◽  
Yuting Gong ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Mouse Model ◽  
Iga Nephropathy ◽  
Therapeutic Effect ◽  
Indoleamine 2,3 Dioxygenase

scholarly journals 1025. Therapeutic Effect of a Self-Cleaving Hammerhead Ribozyme in a Mouse Model of Osteogenesis Imperfecta

2006 ◽  
Vol 13 ◽  
pp. S394
Author(s):  
Belinda E. Peace ◽  
Christopher J. Frede ◽  
Jane B. Florer ◽  
Michael W. Kilpatrick ◽  
Petros Tsipouras ◽  
...  
Keyword(s):  
Mouse Model ◽  
Osteogenesis Imperfecta ◽  
Therapeutic Effect ◽  
Hammerhead Ribozyme
Sign in / Sign up

Export Citation Format

Share Document