Therapeutic Effect of Kakkonto in a Mouse Model of Food Allergy with Gastrointestinal Symptoms

2009 ◽  
Vol 148 (3) ◽  
pp. 175-185 ◽  
Author(s):  
Takeshi Yamamoto ◽  
Kanae Fujiwara ◽  
Minako Yoshida ◽  
Natsuko Kageyama-Yahara ◽  
Hirofumi Kuramoto ◽  
...  
Keyword(s):  
Food Allergy ◽  
Mouse Model ◽  
Therapeutic Effect ◽  
Gastrointestinal Symptoms

Anti-allergenic effects of peanut sprouts extract in a systemic anaphylaxis food allergy mouse model

2019 ◽  
Author(s):  
WK Yang ◽  
DS Kim ◽  
E Son ◽  
YM Lee ◽  
DS Lee ◽  
...  
Keyword(s):  
Food Allergy ◽  
Mouse Model ◽  
Systemic Anaphylaxis

scholarly journals Gastric Enzyme Supplementation Inhibits Food Allergy in a BALB/c Mouse Model

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 738
Author(s):  
Nazanin Samadi ◽  
Denise Heiden ◽  
Martina Klems ◽  
Martina Salzmann ◽  
Johanna Rohrhofer ◽  
...  
Keyword(s):  
Food Allergy ◽  
Mouse Model ◽  
Gastric Acid ◽  
Clinical Symptoms ◽  
Acid Suppression ◽  
Gastric Digestion ◽  
Enzyme Solution ◽  
Allergic Symptoms ◽  
Gastric Acid Suppression ◽  
The Impact

Impaired gastric digestion due to suppressed gastric acidity enhances the risk for food allergy development. In the current study, we aimed to evaluate the impact of a supported gastric digestion via application of a pharmaceutical gastric enzyme solution (GES) on food allergy development and allergic reactions in a BALB/c mouse model. The ability of the GES to restore hypoacidic conditions was tested in mice treated with gastric acid suppression medication. To evaluate the impact on allergic symptoms, mice were orally sensitized with ovalbumin (OVA) under gastric acid suppression and subjected to oral challenges with or without GES. The immune response was evaluated by measurement of antibody titers, cytokine levels, mucosal allergy effector cell influx and regulatory T-cell counts. Clinical response was objectified by core body temperature measurements after oral OVA challenge. Supplementation of GES transiently restored physiological pH levels in the stomach after pharmaceutical gastric acid suppression. During oral sensitization, supplementation of gastric enzymes significantly reduced systemic IgE, IgG1 and IgG2a levels and allergic symptoms. In food allergic mice, clinical symptoms were reduced by co-administration of the gastric enzyme solution. Support of gastric digestion efficiently prevents food allergy induction and alleviates clinical symptoms in our food allergy model.

Study on alleviation effect of stachyose on food allergy through TLR2/NF-κB signal pathway in a mouse model

Life Sciences ◽  
2021 ◽  
pp. 120038
Author(s):  
Qian Li ◽  
Xinlei Tang ◽  
Jianghao Xu ◽  
Xingyuan Ren ◽  
Rui Wang ◽  
...  
Keyword(s):  
Food Allergy ◽  
Mouse Model ◽  
Signal Pathway

scholarly journals Therapeutic Effect of Berberine on Huntington’s Disease Transgenic Mouse Model

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0134142 ◽  
Author(s):  
Wenxiao Jiang ◽  
Wenjie Wei ◽  
Marta A. Gaertig ◽  
Shihua Li ◽  
Xiao-Jiang Li
Keyword(s):  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Transgenic Mouse ◽  
Therapeutic Effect ◽  
Transgenic Mouse Model

scholarly journals Structural changes induced by heating affect ovalbumin-antigen processing and reduce allergic response in mouse model of food allergy

2014 ◽  
Vol 4 (S2) ◽  
Author(s):  
Jaroslav Goliáš ◽  
Martin Schwarzer ◽  
Hana Kozáková ◽  
Dagmar Šrùtková ◽  
Ludmila Tuèková
Keyword(s):  
Food Allergy ◽  
Mouse Model ◽  
Antigen Processing ◽  
Structural Changes ◽  
Allergic Response

The therapeutic effect of dendritic cells expressing indoleamine 2,3-dioxygenase (IDO) on an IgA nephropathy mouse model

2020 ◽  
Vol 52 (2) ◽  
pp. 399-407 ◽  
Author(s):  
Kanghan Liu ◽  
Yiya Yang ◽  
Yinyin Chen ◽  
Shiyao Li ◽  
Yuting Gong ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Mouse Model ◽  
Iga Nephropathy ◽  
Therapeutic Effect ◽  
Indoleamine 2,3 Dioxygenase

scholarly journals 1025. Therapeutic Effect of a Self-Cleaving Hammerhead Ribozyme in a Mouse Model of Osteogenesis Imperfecta

2006 ◽  
Vol 13 ◽  
pp. S394
Author(s):  
Belinda E. Peace ◽  
Christopher J. Frede ◽  
Jane B. Florer ◽  
Michael W. Kilpatrick ◽  
Petros Tsipouras ◽  
...  
Keyword(s):  
Mouse Model ◽  
Osteogenesis Imperfecta ◽  
Therapeutic Effect ◽  
Hammerhead Ribozyme
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