scholarly journals Transcutaneous Vagus Nerve Stimulation Regulates the Cholinergic Anti-inflammatory Pathway to Counteract 1, 2-Dimethylhydrazine Induced Colon Carcinogenesis in Albino wistar Rats

2019 ◽  
Vol 10 ◽  
Author(s):  
Jitendra K. Rawat ◽  
Subhadeep Roy ◽  
Manjari Singh ◽  
Swetlana Guatam ◽  
Rajnish K. Yadav ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Wistar Rats ◽  
Colon Carcinogenesis ◽  
Inflammatory Pathway ◽  
Transcutaneous Vagus Nerve Stimulation ◽  
Anti Inflammatory

Vagus nerve stimulation: from epilepsy to the cholinergic anti-inflammatory pathway

2013 ◽  
Vol 25 (3) ◽  
pp. 208-221 ◽  
Author(s):  
B. Bonaz ◽  
C. Picq ◽  
V. Sinniger ◽  
J. F. Mayol ◽  
D. Clarençon
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Inflammatory Pathway ◽  
Anti Inflammatory

scholarly journals The cholinergic anti-inflammatory pathway in chronic kidney disease—review and vagus nerve stimulation clinical pilot study

2020 ◽  
Vol 35 (11) ◽  
pp. 1840-1852
Author(s):  
Marie Hilderman ◽  
Annette Bruchfeld
Keyword(s):  
Chronic Kidney Disease ◽  
Pilot Study ◽  
Kidney Disease ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Cell Injury ◽  
Inflammatory Pathway ◽  
Increased Risk ◽  
Anti Inflammatory

Abstract Inflammation and autonomic dysfunction are common findings in chronic and end-stage kidney disease and contribute to a markedly increased risk of mortality in this patient population. The cholinergic anti-inflammatory pathway (CAP) is a vagal neuro-immune circuit that upholds the homoeostatic balance of inflammatory activity in response to cell injury and pathogens. CAP models have been examined in preclinical studies to investigate its significance in a range of clinical inflammatory conditions and diseases. More recently, cervical vagus nerve stimulation (VNS) implants have been shown to be of potential benefit for patients with chronic autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease. We have previously shown that dialysis patients have a functional CAP ex vivo. Here we review the field and the potential role of the CAP in acute kidney injury and chronic kidney disease (CKD) as well as in hypertension. We also present a VNS pilot study in haemodialysis patients. Controlling inflammation by neuroimmune modulation may lead to new therapeutic modalities for improved treatment, outcome, prognosis and quality of life for patients with CKD.

scholarly journals Transcutaneous Auricular Vagus Nerve Stimulation Protects Endotoxemic Rat from Lipopolysaccharide-Induced Inflammation

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Yu Xue Zhao ◽  
Wei He ◽  
Xiang Hong Jing ◽  
Jun Ling Liu ◽  
Pei Jing Rong ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Proinflammatory Cytokines ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Inflammatory Responses ◽  
Interleukin 1 ◽  
Nf Kappa B ◽  
Necrosis Factor Alpha ◽  
Inflammatory Pathway ◽  
Anti Inflammatory

Background. Transcutaneous auricular vagus nerve stimulation (ta-VNS) could evoke parasympathetic activities via activating the brainstem autonomic nuclei, similar to the effects that are produced after vagus nerve stimulation (VNS). VNS modulates immune function through activating the cholinergic anti-inflammatory pathway.Methods. VNS, ta-VNS, or transcutaneous electrical acupoint stimulation (TEAS) on ST36 was performed to modulate the inflammatory response. The concentration of serum proinflammatory cytokines and tissue NF-kappa B p65 (NF-κB p65) were detected in endotoxaemia affected anesthetized rats.Results. Similar to the effect of VNS, ta-VNS suppressed the serum proinflammatory cytokines levels, such as tumour necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6) as well as NF-kappa B p65 expressions of lung tissues. ST36 stimulation also decreases LPS-induced high TNF-αlevel and NF-κB signal, but it did not restrain proinflammatory cytokine IL-1βand IL-6. Neither ta-VNS nor ST36 stimulation could suppress LPS-induced TNF-αand NF-κB after vagotomy or withα7nAChR antagonist injection.Conclusions. The present paper demonstrated that ta-VNS could be utilized to suppress LPS-induced inflammatory responses viaα7nAChR-mediated cholinergic anti-inflammatory pathway.

scholarly journals Vagal Nerve Stimulation-Modulation of the Anti-Inflammatory Response and Clinical Outcome in Psoriatic Arthritis or Ankylosing Spondylitis

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
C. Brock ◽  
S. E. Rasmussen ◽  
A. M. Drewes ◽  
H. J. Møller ◽  
B. Brock ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Ankylosing Spondylitis ◽  
Vagus Nerve ◽  
Disease Activity ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Vagal Nerve ◽  
Clinical Disease ◽  
Transcutaneous Vagus Nerve Stimulation ◽  
Anti Inflammatory

Objectives. The vagal nerve exerts an essential pathway in controlling the cholinergic anti-inflammatory reflex. Thus, the study is aimed at investigating the acute effect of a noninvasive transcutaneous vagus nerve stimulation on clinical disease activity and systemic levels of inflammation in patients with psoriatic arthritis or ankylosing spondylitis. Methods. Twenty patients with psoriatic arthritis (PsA) and 20 patients with ankylosing spondylitis (AS) were included and stimulated bilaterally with a handheld vagal nerve stimulator for 120 seconds 3 times a day for 5 consecutive days. All patients were in remission. Cardiac vagal tone, clinical scores, CRP, and cytokine levels were assessed. Results. In PsA and AS, decreased heart rate was observed, confirming compliance. Furthermore, in PsA, a clear reduction of clinical disease activity associated with a 20% reduction in CRP was shown. In AS, a reduction in interferon-γ, interleukin- (IL-) 8, and 10 was shown. No side effects were described. Conclusion. This open-label study provides support for an anti-inflammatory effect of transcutaneous vagus nerve stimulation in patients with psoriatic arthritis and ankylosing spondylitis. The modulated immune response and reduced disease activity and CRP-levels raise the fascinating possibility of using neuromodulation as an add-on to existing pharmacological treatments.

scholarly journals Vagus Nerve Stimulation Protects Enterocyte Glycocalyx After Hemorrhagic Shock Via The Cholinergic Anti-Inflammatory Pathway

Shock ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Juan Wu ◽  
Yushuang Yin ◽  
Mingzhe Qin ◽  
Kun Li ◽  
Fang Liu ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Hemorrhagic Shock ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Inflammatory Pathway ◽  
Anti Inflammatory

Effect of Transcutaneous Vagus Nerve Stimulation in Dysphagia After Lateral Medullary Infarction: A Case Report

2019 ◽  
Vol 28 (4) ◽  
pp. 1381-1387
Author(s):  
Ying Yuan ◽  
Jie Wang ◽  
Dongyu Wu ◽  
Dahua Zhang ◽  
Weiqun Song
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Rating Scale ◽  
Tube Feeding ◽  
Nasogastric Feeding ◽  
Lateral Medullary Infarction ◽  
Severe Dysphagia ◽  
Transcutaneous Vagus Nerve Stimulation ◽  
Medullary Infarction

Purpose Severe dysphagia with weak pharyngeal peristalsis after dorsal lateral medullary infarction (LMI) requires long-term tube feeding. However, no study is currently available on therapeutic effectiveness in severe dysphagia caused by nuclear damage of vagus nerve after dorsal LMI. The purpose of the present investigation was to explore the potential of transcutaneous vagus nerve stimulation (tVNS) to improve severe dysphagia with weak pharyngeal peristalsis after dorsal LMI. Method We assessed the efficacy of 6-week tVNS in a 28-year-old woman presented with persisting severe dysphagia after dorsal LMI who had been on nasogastric feeding for 6 months. tVNS was applied for 20 min twice a day, 5 days a week, for 6 weeks. The outcome measures included saliva spitted, Swallow Function Scoring System, Functional Oral Intake Scale, Clinical Assessment of Dysphagia With Wallenberg Syndrome, Yale Pharyngeal Residue Severity Rating Scale, and upper esophagus X-ray examination. Results After tVNS, the patient was advanced to a full oral diet without head rotation or spitting. No saliva residue was found in the valleculae and pyriform sinuses. Contrast medium freely passed through the upper esophageal sphincter. Conclusion Our findings suggest that tVNS might provide a useful means for recovery of severe dysphagia with weak pharyngeal peristalsis after dorsal LMI. Supplemental Material https://doi.org/10.23641/asha.9755438

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