Vagus nerve stimulation: from epilepsy to the cholinergic anti-inflammatory pathway

2013 ◽  
Vol 25 (3) ◽  
pp. 208-221 ◽  
Author(s):  
B. Bonaz ◽  
C. Picq ◽  
V. Sinniger ◽  
J. F. Mayol ◽  
D. Clarençon
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Inflammatory Pathway ◽  
Anti Inflammatory

scholarly journals The cholinergic anti-inflammatory pathway in chronic kidney disease—review and vagus nerve stimulation clinical pilot study

2020 ◽  
Vol 35 (11) ◽  
pp. 1840-1852
Author(s):  
Marie Hilderman ◽  
Annette Bruchfeld
Keyword(s):  
Chronic Kidney Disease ◽  
Pilot Study ◽  
Kidney Disease ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Cell Injury ◽  
Inflammatory Pathway ◽  
Increased Risk ◽  
Anti Inflammatory

Abstract Inflammation and autonomic dysfunction are common findings in chronic and end-stage kidney disease and contribute to a markedly increased risk of mortality in this patient population. The cholinergic anti-inflammatory pathway (CAP) is a vagal neuro-immune circuit that upholds the homoeostatic balance of inflammatory activity in response to cell injury and pathogens. CAP models have been examined in preclinical studies to investigate its significance in a range of clinical inflammatory conditions and diseases. More recently, cervical vagus nerve stimulation (VNS) implants have been shown to be of potential benefit for patients with chronic autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease. We have previously shown that dialysis patients have a functional CAP ex vivo. Here we review the field and the potential role of the CAP in acute kidney injury and chronic kidney disease (CKD) as well as in hypertension. We also present a VNS pilot study in haemodialysis patients. Controlling inflammation by neuroimmune modulation may lead to new therapeutic modalities for improved treatment, outcome, prognosis and quality of life for patients with CKD.

scholarly journals Transcutaneous Auricular Vagus Nerve Stimulation Protects Endotoxemic Rat from Lipopolysaccharide-Induced Inflammation

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Yu Xue Zhao ◽  
Wei He ◽  
Xiang Hong Jing ◽  
Jun Ling Liu ◽  
Pei Jing Rong ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Proinflammatory Cytokines ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Inflammatory Responses ◽  
Interleukin 1 ◽  
Nf Kappa B ◽  
Necrosis Factor Alpha ◽  
Inflammatory Pathway ◽  
Anti Inflammatory

Background. Transcutaneous auricular vagus nerve stimulation (ta-VNS) could evoke parasympathetic activities via activating the brainstem autonomic nuclei, similar to the effects that are produced after vagus nerve stimulation (VNS). VNS modulates immune function through activating the cholinergic anti-inflammatory pathway.Methods. VNS, ta-VNS, or transcutaneous electrical acupoint stimulation (TEAS) on ST36 was performed to modulate the inflammatory response. The concentration of serum proinflammatory cytokines and tissue NF-kappa B p65 (NF-κB p65) were detected in endotoxaemia affected anesthetized rats.Results. Similar to the effect of VNS, ta-VNS suppressed the serum proinflammatory cytokines levels, such as tumour necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6) as well as NF-kappa B p65 expressions of lung tissues. ST36 stimulation also decreases LPS-induced high TNF-αlevel and NF-κB signal, but it did not restrain proinflammatory cytokine IL-1βand IL-6. Neither ta-VNS nor ST36 stimulation could suppress LPS-induced TNF-αand NF-κB after vagotomy or withα7nAChR antagonist injection.Conclusions. The present paper demonstrated that ta-VNS could be utilized to suppress LPS-induced inflammatory responses viaα7nAChR-mediated cholinergic anti-inflammatory pathway.

scholarly journals Vagus Nerve Stimulation Protects Enterocyte Glycocalyx After Hemorrhagic Shock Via The Cholinergic Anti-Inflammatory Pathway

Shock ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Juan Wu ◽  
Yushuang Yin ◽  
Mingzhe Qin ◽  
Kun Li ◽  
Fang Liu ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Hemorrhagic Shock ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Inflammatory Pathway ◽  
Anti Inflammatory

W1706 Anti-Inflammatory Effect of Vagus Nerve Stimulation in a Rat Model of Colitis

2009 ◽  
Vol 136 (5) ◽  
pp. A-721
Author(s):  
Julien Meregnani ◽  
Clarençon Didier ◽  
Chloé A. Picq ◽  
Valérie Sinniger ◽  
Bruno L. Bonaz
Keyword(s):  
Vagus Nerve ◽  
Rat Model ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Anti-inflammatory Effects of Abdominal Vagus Nerve Stimulation on Experimental Intestinal Inflammation

2019 ◽  
Vol 13 ◽  
Author(s):  
Sophie C. Payne ◽  
John B. Furness ◽  
Owen Burns ◽  
Alicia Sedo ◽  
Tomoko Hyakumura ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Intestinal Inflammation ◽  
Anti Inflammatory

scholarly journals Vagus Nerve Stimulation in Refractory Epilepsy: Effects on Pro- and Anti-Inflammatory Cytokines in Peripheral Blood

2011 ◽  
Vol 18 (1) ◽  
pp. 52-56 ◽  
Author(s):  
H.J.M. Majoie ◽  
K. Rijkers ◽  
M.W. Berfelo ◽  
J.A.R.J. Hulsman ◽  
A. Myint ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Inflammatory Cytokines ◽  
Nerve Stimulation ◽  
Peripheral Blood ◽  
Vagus Nerve Stimulation ◽  
Refractory Epilepsy ◽  
Anti Inflammatory
Sign in / Sign up

Export Citation Format

Share Document