scholarly journals Butyrate Protects Mice Against Methionine–Choline-Deficient Diet-Induced Non-alcoholic Steatohepatitis by Improving Gut Barrier Function, Attenuating Inflammation and Reducing Endotoxin Levels

2018 ◽  
Vol 9 ◽  
Author(s):  
Jianzhong Ye ◽  
Longxian Lv ◽  
Wenrui Wu ◽  
Yating Li ◽  
Ding Shi ◽  
...  
Keyword(s):  
Barrier Function ◽  
Gut Barrier ◽  
Deficient Diet ◽  
Alcoholic Steatohepatitis ◽  
Gut Barrier Function

Bofutsushosan Improves Gut Barrier Function with a Bloom of Akkermansia Muciniphila and Improves Glucose Metabolism in Diet-Induced Obese Mice

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1990-P ◽  
Author(s):  
SHIHO FUJISAKA ◽  
ISAO USUI ◽  
ALLAH NAWAZ ◽  
YOSHIKO IGARASHI ◽  
TOMONOBU KADO ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Barrier Function ◽  
Obese Mice ◽  
Gut Barrier ◽  
Akkermansia Muciniphila ◽  
Gut Barrier Function

scholarly journals The Mucus Layer is Critical in Protecting Against Ischemia-Reperfusion-Mediated Gut Injury and in the Restitution of Gut Barrier Function

Shock ◽  
2011 ◽  
Vol 35 (3) ◽  
pp. 275-281 ◽  
Author(s):  
Xiaofa Qin ◽  
Sharvil U. Sheth ◽  
Susan M. Sharpe ◽  
Wei Dong ◽  
Qi Lu ◽  
...  
Keyword(s):  
Barrier Function ◽  
Ischemia Reperfusion ◽  
Mucus Layer ◽  
Gut Barrier ◽  
Gut Barrier Function

Lycium ruthenicum diet alters the gut microbiota and partially enhances gut barrier function in male C57BL/6 mice

2019 ◽  
Vol 52 ◽  
pp. 516-528 ◽  
Author(s):  
Baoming Tian ◽  
Jianhua Zhao ◽  
Wei An ◽  
Jiawei Zhang ◽  
Xin Cao ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Barrier Function ◽  
Gut Barrier ◽  
Gut Barrier Function ◽  
Lycium Ruthenicum

scholarly journals Clinical Analysis of Gut Barrier Dysfunction in Patients with Advanced Colorectal Cancer Undergoing Cytoreductive Surgery and HIPEC

2021 ◽  
Author(s):  
Le lai Ping ◽  
Jiang xu Mian ◽  
Chen Wei
Keyword(s):  
Colorectal Cancer ◽  
Cytoreductive Surgery ◽  
Barrier Function ◽  
Intraperitoneal Injection ◽  
Advanced Colorectal Cancer ◽  
Patient Characteristics ◽  
Barrier Dysfunction ◽  
Large Area ◽  
Gut Barrier ◽  
Gut Barrier Function

Abstract Introduction: Hyperthermic intraperitoneal chemotherapy combinedwith cytoreductive surgery is a preferred treatment option for advanced colorectal cancer patients. However, little is known whether the HIPEC can cause the damage of gut barrier function.Methods: A total of 123 patients underwent surgical resection for advanced CRC. Sixty-five patients were treated HIPEC after cytoreductive surgery whereas 58 patients underwent surgery only. Gut barrier function were evaluated using the expression of serum DAO/D-la/ET on D1/D5/D10 after surgery. Both groups were compared for patient characteristics, perioperative data and gut barrier function. Moreover, rats received intraperitoneal injection of retetrexed to observe possible changes of colonic structure under optical microscope.Results: Both groups were comparable with respect to general patient characteristics and post-operative complications. The HIPEC+CRS group was associated with a higher postoperative serum level of DAO/D-la on D1/D5 (p < 0.05) and ET on D5 after surgery (p < 0.05) than that of the surgery only group. Ten days after surgery showed no statistical difference between the 2 groups (p > 0.05).A large area structure disorder, epithelial necrosis, glandular deformation and a large number of lymphocytes infiltration was found in the lamina propria in animals received intraperitoneal injection of retetrexed.Conclusion: In this study, CRS combined with HIPEC does have but only an irreversible impact on gut barrier for advanced CRC patients.

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