scholarly journals Spinacetin Suppresses the Mast Cell Activation and Passive Cutaneous Anaphylaxis in Mouse Model

2018 ◽  
Vol 9 ◽  
Author(s):  
Ning Ji ◽  
Shunli Pan ◽  
Chen Shao ◽  
Yufen Chen ◽  
Zhe Zhang ◽  
...  
Keyword(s):  
Mast Cell ◽  
Mouse Model ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Passive Cutaneous Anaphylaxis

scholarly journals Viridicatol Isolated from Deep-Sea Penicillium Griseofulvum Alleviates Anaphylaxis and Repairs the Intestinal Barrier in Mice by Suppressing Mast Cell Activation

Marine Drugs ◽  
2020 ◽  
Vol 18 (10) ◽  
pp. 517
Author(s):  
Zhendan Shu ◽  
Qingmei Liu ◽  
Cuiping Xing ◽  
Yafen Zhang ◽  
Yu Zhou ◽  
...  
Keyword(s):  
Mast Cell ◽  
Mouse Model ◽  
Deep Sea ◽  
Cell Activation ◽  
Immunoglobulin E ◽  
Cell Model ◽  
Intestinal Barrier ◽  
Interleukin 10 ◽  
Mast Cell Activation ◽  
Penicillium Griseofulvum

Viridicatol is a quinoline alkaloid isolated from the deep-sea-derived fungus Penicillium griseofulvum. The structure of viridicatol was unambiguously established by X-ray diffraction analysis. In this study, a mouse model of ovalbumin-induced food allergy and the rat basophil leukemia (RBL)-2H3 cell model were established to explore the anti-allergic properties of viridicatol. On the basis of the mouse model, we found viridicatol to alleviate the allergy symptoms; decrease the levels of specific immunoglobulin E, mast cell protease-1, histamine, and tumor necrosis factor-α; and promote the production of interleukin-10 in the serum. The treatment of viridicatol also downregulated the population of B cells and mast cells (MCs), as well as upregulated the population of regulatory T cells in the spleen. Moreover, viridicatol alleviated intestinal villi injury and inhibited the degranulation of intestinal MCs to promote intestinal barrier repair in mice. Furthermore, the accumulation of Ca2+ in RBL-2H3 cells was significantly suppressed by viridicatol, which could block the activation of MCs. Taken together, these data indicated that deep-sea viridicatol may represent a novel therapeutic for allergic diseases.

5-Bromo-3,4-dihydroxybenzaldehyde from Polysiphonia morrowii attenuate IgE/BSA-stimulated mast cell activation and passive cutaneous anaphylaxis in mice

2020 ◽  
Vol 178 ◽  
pp. 114087 ◽  
Author(s):  
Eui Jeong Han ◽  
Ilekuttige Priyan Shanura Fernando ◽  
Eun-A Kim ◽  
Junseong Kim ◽  
Kyungsook Jung ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Passive Cutaneous Anaphylaxis

miRNA-155 controls mast cell activation by regulating the PI3Kγ pathway and anaphylaxis in a mouse model

Allergy ◽  
2014 ◽  
Vol 69 (6) ◽  
pp. 752-762 ◽  
Author(s):  
K. Biethahn ◽  
Z. Orinska ◽  
E. Vigorito ◽  
D. A. Goyeneche-Patino ◽  
F. Mirghomizadeh ◽  
...  
Keyword(s):  
Mast Cell ◽  
Mouse Model ◽  
Cell Activation ◽  
Mast Cell Activation
Sign in / Sign up

Export Citation Format

Share Document