The inhibitory activity of atractylenolide Ш, a sesquiterpenoid, on IgE-mediated mast cell activation and passive cutaneous anaphylaxis (PCA)

2013 ◽  
Vol 145 (1) ◽  
pp. 278-285 ◽  
Author(s):  
Nan-nan Zhang ◽  
Dong Ki Park ◽  
Hye-Jin Park
Keyword(s):  
Mast Cell ◽  
Inhibitory Activity ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Passive Cutaneous Anaphylaxis ◽  
Ige Mediated

Identification of the minimal region of peptide derived from ADP-ribosylation factor1 (ARF1) that inhibits IgE-mediated mast cell activation

2019 ◽  
Vol 105 ◽  
pp. 32-37 ◽  
Author(s):  
Ryota Uchida ◽  
Tomonori Egawa ◽  
Yoshio Fujita ◽  
Kazuyuki Furuta ◽  
Hiroaki Taguchi ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Adp Ribosylation ◽  
Ige Mediated ◽  
Minimal Region

scholarly journals Beyond IgE: Alternative Mast Cell Activation Across Different Disease States

2020 ◽  
Vol 21 (4) ◽  
pp. 1498 ◽  
Author(s):  
David O. Lyons ◽  
Nicholas A. Pullen
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Cell Activation ◽  
Autoimmune Disorders ◽  
Receptor Expression ◽  
Mast Cell Activation ◽  
Food Allergies ◽  
Type I ◽  
Disease States ◽  
Ige Mediated

Mast cells are often regarded through the lens of IgE-dependent reactions as a cell specialized only for anti-parasitic and type I hypersensitive responses. However, recently many researchers have begun to appreciate the expansive repertoire of stimuli that mast cells can respond to. After the characterization of the interleukin (IL)-33/suppression of tumorigenicity 2 (ST2) axis of mast cell activation—a pathway that is independent of the adaptive immune system—researchers are revisiting other stimuli to induce mast cell activation and/or subsequent degranulation independent of IgE. This discovery also underscores that mast cells act as important mediators in maintaining body wide homeostasis, especially through barrier defense, and can thus be the source of disease as well. Particularly in the gut, inflammatory bowel diseases (Crohn’s disease, ulcerative colitis, etc.) are characterized with enhanced mast cell activity in the context of autoimmune disease. Mast cells show phenotypic differences based on tissue residency, which could manifest as different receptor expression profiles, allowing for unique mast cell responses (both IgE and non-IgE mediated) across varying tissues as well. This variety in receptor expression suggests mast cells respond differently, such as in the gut where immunosuppressive IL-10 stimulates the development of food allergy or in the lungs where transforming growth factor-β1 (TGF-β1) can enhance mast cell IL-6 production. Such differences in receptor expression illustrate the truly diverse effector capabilities of mast cells, and careful consideration must be given toward the phenotype of mast cells observed in vitro. Given mast cells’ ubiquitous tissue presence and their capability to respond to a broad spectrum of non-IgE stimuli, it is expected that mast cells may also contribute to the progression of autoimmune disorders and other disease states such as metastatic cancer through promoting chronic inflammation in the local tissue microenvironment and ultimately polarizing toward a unique Th17 immune response. Furthermore, these interconnected, atypical activation pathways may crosstalk with IgE-mediated signaling differently across disorders such as parasitism, food allergies, and autoimmune disorders of the gut. In this review, we summarize recent research into familiar and novel pathways of mast cells activation and draw connections to clinical human disease.

scholarly journals Alpha7-nicotinic acetylcholine receptors involve the imidacloprid-induced inhibition of IgE-mediated rat and human mast cell activation

RSC Advances ◽  
2017 ◽  
Vol 7 (82) ◽  
pp. 51896-51906 ◽  
Author(s):  
Linbo Shi ◽  
Huaping Xu ◽  
Yujie Wu ◽  
Xin Li ◽  
Li Zou ◽  
...  
Keyword(s):  
Mast Cell ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Human Mast Cell ◽  
Inhibition Mechanism ◽  
Nicotinic Acetylcholine ◽  
Neonicotinoid Insecticide ◽  
Ige Mediated

Although our recent study indicated that imidacloprid, a widely used neonicotinoid insecticide, inhibited IgE-mediated mast cell activation, the inhibition mechanism still remains unclear.

scholarly journals Direct Inhibition of the Allergic Effector Response by Raw Cow’s Milk—An Extensive In Vitro Assessment

Cells ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 1258
Author(s):  
Suzanne Abbring ◽  
Bart R. J. Blokhuis ◽  
Julie L. Miltenburg ◽  
Kiri G. J. Romano Olmedo ◽  
Johan Garssen ◽  
...  
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Cell Activation ◽  
Allergic Diseases ◽  
Raw Milk ◽  
Mast Cell Activation ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Ige Mediated ◽  
Raw Cow’S Milk

The mechanisms underlying the allergy-protective effects of raw cow’s milk are poorly understood. The current focus is mainly on the modulation of T cell responses. In the present study, we investigated whether raw cow’s milk can also directly inhibit mast cells, the key effector cells in IgE-mediated allergic responses. Primary murine bone marrow-derived mast cells (BMMC) and peritoneal mast cells (PMC), were incubated with raw milk, heated raw milk, or shop milk, prior to IgE-mediated activation. The effects on mast cell activation and underlying signaling events were assessed. Raw milk was furthermore fractionated based on molecular size and obtained fractions were tested for their capacity to reduce IgE-mediated mast cell activation. Coincubation of BMMC and PMC with raw milk prior to activation reduced β-hexosaminidase release and IL-6 and IL-13 production, while heated raw milk or shop milk had no effect. The reduced mast cell activation coincided with a reduced intracellular calcium influx. In addition, SYK and ERK phosphorylation levels, both downstream signaling events of the FcεRI, were lower in raw milk-treated BMMC compared to control BMMC, although differences did not reach full significance. Raw milk-treated BMMC furthermore retained membrane-bound IgE expression after allergen stimulation. Raw milk fractionation showed that the heat-sensitive raw milk components responsible for the reduced mast cell activation are likely to have a molecular weight of > 37 kDa. The present study demonstrates that raw cow’s milk can also directly affect mast cell activation. These results extend the current knowledge on mechanisms via which raw cow’s milk prevents allergic diseases, which is crucial for the development of new, microbiologically safe, nutritional strategies to reduce allergic diseases.

scholarly journals The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Kwok Ho Yip ◽  
Natasha Kolesnikoff ◽  
Nicholas Hauschild ◽  
Lisa Biggs ◽  
Angel F. Lopez ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Activation ◽  
Negative Regulator ◽  
Mast Cell Activation ◽  
Ige Mediated

Inhibitory Effect of Açaí (Euterpe oleracea Mart.) Pulp on IgE-Mediated Mast Cell Activation

2011 ◽  
Vol 59 (10) ◽  
pp. 5595-5601 ◽  
Author(s):  
Tomoko Horiguchi ◽  
Nahoko Ishiguro ◽  
Kazuyasu Chihara ◽  
Kazuhiro Ogi ◽  
Kenji Nakashima ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Activation ◽  
Inhibitory Effect ◽  
Mast Cell Activation ◽  
Euterpe Oleracea ◽  
Ige Mediated ◽  
Euterpe Oleracea Mart

scholarly journals DJ-1 regulates mast cell activation and IgE-mediated allergic responses

2013 ◽  
Vol 131 (6) ◽  
pp. 1653-1662.e1 ◽  
Author(s):  
Do Kyun Kim ◽  
Hyuk Soon Kim ◽  
A-Ram Kim ◽  
Ji Hyung Kim ◽  
Bokyung Kim ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Ige Mediated
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