Applying a Global Sensitivity Analysis Workflow to Improve the Computational Efficiencies in Physiologically-Based Pharmacokinetic Modeling

Frontiers in Pharmacology ◽

10.3389/fphar.2018.00588 ◽

2018 ◽

Vol 9 ◽

Cited By ~ 16

Author(s):

Nan-Hung Hsieh ◽

Brad Reisfeld ◽

Frederic Y. Bois ◽

Weihsueh A. Chiu

Keyword(s):

Sensitivity Analysis ◽

Global Sensitivity Analysis ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Global Sensitivity ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Analysis Workflow

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Assessing drug distribution in tissues expressing P-glycoprotein using physiologically based pharmacokinetic modeling: identification of important model parameters through global sensitivity analysis

Journal of Pharmacokinetics and Pharmacodynamics ◽

10.1007/s10928-009-9134-8 ◽

2009 ◽

Vol 36 (6) ◽

pp. 495-522 ◽

Cited By ~ 10

Author(s):

Frederique Fenneteau ◽

Jun Li ◽

Fahima Nekka

Keyword(s):

Sensitivity Analysis ◽

Global Sensitivity Analysis ◽

Drug Distribution ◽

Pharmacokinetic Modeling ◽

Model Parameters ◽

Physiologically Based Pharmacokinetic Modeling ◽

Global Sensitivity ◽

Physiologically Based Pharmacokinetic ◽

P Glycoprotein ◽

Physiologically Based

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Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 2. Rational Bioavailability Design by Global Sensitivity Analysis To Identify Properties Affecting Bioavailability

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.7b00973 ◽

2018 ◽

Vol 15 (3) ◽

pp. 831-839 ◽

Cited By ~ 4

Author(s):

Pankaj R. Daga ◽

Michael B. Bolger ◽

Ian S. Haworth ◽

Robert D. Clark ◽

Eric J. Martin

Keyword(s):

Sensitivity Analysis ◽

Global Sensitivity Analysis ◽

Pharmacokinetic Modeling ◽

Lead Optimization ◽

Physiologically Based Pharmacokinetic Modeling ◽

Global Sensitivity ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Prediction of the disposition of a P-gp substrate in wild-type and knockout mice tissues: Development of a physiologically based pharmacokinetic (PBPK) model and its global sensitivity analysis

PAMM ◽

10.1002/pamm.200700608 ◽

2007 ◽

Vol 7 (1) ◽

pp. 1121905-1121906 ◽

Cited By ~ 1

Author(s):

F. Fenneteau ◽

J. Li ◽

L. Couture ◽

J. Turgeon ◽

F. Nekka

Keyword(s):

Sensitivity Analysis ◽

Knockout Mice ◽

Pbpk Model ◽

Global Sensitivity Analysis ◽

Wild Type ◽

Global Sensitivity ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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COMPARATIVE ANALYSIS OF SOFTWARE FOR PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING: SIMULATION, OPTIMIZATION, AND SENSITIVITY ANALYSIS

Toxicology Methods ◽

10.1080/10517230050121615 ◽

2000 ◽

Vol 10 (3) ◽

pp. 203-229 ◽

Cited By ~ 12

Author(s):

Michael R. Easterling ◽

Marina V Evans ◽

Elaina M. Kenyon

Keyword(s):

Sensitivity Analysis ◽

Comparative Analysis ◽

Simulation Optimization ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Modeling Simulation ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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The application of global sensitivity analysis in the development of a physiologically based pharmacokinetic model for m-xylene and ethanol co-exposure in humans

Frontiers in Pharmacology ◽

10.3389/fphar.2015.00135 ◽

2015 ◽

Vol 6 ◽

Cited By ~ 4

Author(s):

George D. Loizou ◽

Kevin McNally ◽

Kate Jones ◽

John Cocker

Keyword(s):

Sensitivity Analysis ◽

Pharmacokinetic Model ◽

Global Sensitivity Analysis ◽

Physiologically Based Pharmacokinetic Model ◽

Global Sensitivity ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Reducing Whole Body Physiologically Based Pharmacokinetic Models Using Global Sensitivity Analysis: Diazepam Case Study

Journal of Pharmacokinetics and Pharmacodynamics ◽

10.1007/s10928-005-0004-8 ◽

2005 ◽

Vol 33 (1) ◽

pp. 1-27 ◽

Cited By ~ 33

Author(s):

Ivelina Gueorguieva ◽

Ivan A. Nestorov ◽

Malcolm Rowland

Keyword(s):

Sensitivity Analysis ◽

Global Sensitivity Analysis ◽

Whole Body ◽

Pharmacokinetic Models ◽

Global Sensitivity ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Variance based global sensitivity analysis of physiologically based pharmacokinetic absorption models for BCS I–IV drugs

Journal of Pharmacokinetics and Pharmacodynamics ◽

10.1007/s10928-018-9615-8 ◽

2018 ◽

Vol 46 (1) ◽

pp. 27-42 ◽

Cited By ~ 3

Author(s):

Nicola Melillo ◽

Leon Aarons ◽

Paolo Magni ◽

Adam S. Darwich

Keyword(s):

Sensitivity Analysis ◽

Global Sensitivity Analysis ◽

Global Sensitivity ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Absorption Models

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Important pharmacokinetic parameters for individualization of 177 Lu‐PSMA therapy: A global sensitivity analysis for a physiologically‐based pharmacokinetic model

Medical Physics ◽

10.1002/mp.14622 ◽

2020 ◽

Author(s):

Deni Hardiansyah ◽

Peter Kletting ◽

Nusrat J. Begum ◽

Matthias Eiber ◽

Ambros J. Beer ◽

...

Keyword(s):

Sensitivity Analysis ◽

Pharmacokinetic Model ◽

Global Sensitivity Analysis ◽

Pharmacokinetic Parameters ◽

Physiologically Based Pharmacokinetic Model ◽

Global Sensitivity ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically-based pharmacokinetic modeling of different size polyethylene glycol-coated gold nanoparticles in mice

10.1615/ihtc16.nmt.023362 ◽

2018 ◽

Author(s):

Linjing Deng ◽

Jinping Zhao ◽

Yufeng Miao ◽

Xu Hu ◽

Qihong Deng

Keyword(s):

Gold Nanoparticles ◽

Polyethylene Glycol ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically-Based Pharmacokinetic Modeling to Predict Changes in Drug Exposure during Pregnancy Using the Simcyp Simulator

10.26226/morressier.57d6b2b7d462b8028d88e945 ◽

2016 ◽

Author(s):

Suvarchala Kiranmai Avvari

Keyword(s):

Drug Exposure ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Exposure During Pregnancy

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