scholarly journals A Novel Circulating miRNA-Based Model Predicts the Response to Tripterysium Glycosides Tablets: Moving Toward Model-Based Precision Medicine in Rheumatoid Arthritis

2018 ◽  
Vol 9 ◽  
Author(s):  
Yanqiong Zhang ◽  
Hailong Wang ◽  
Xia Mao ◽  
Qiuyan Guo ◽  
Weijie Li ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Precision Medicine ◽  
Circulating Mirna ◽  
Model Based

Model-based Computational Precision Medicine to develop combination therapies for autoimmune diseases

2021 ◽  
Author(s):  
Emiko Desvaux ◽  
Audrey Aussy ◽  
Sandra Hubert ◽  
Florence Keime-Guibert ◽  
Alexia Blesius ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Precision Medicine ◽  
Combination Therapies ◽  
Model Based

scholarly journals The Quest for Evidence for Proton Therapy: Model-Based Approach and Precision Medicine

2016 ◽  
Vol 95 (1) ◽  
pp. 30-36 ◽  
Author(s):  
Joachim Widder ◽  
Arjen van der Schaaf ◽  
Philippe Lambin ◽  
Corrie A.M. Marijnen ◽  
Jean-Philippe Pignol ◽  
...  
Keyword(s):  
Precision Medicine ◽  
Proton Therapy ◽  
Model Based ◽  
Therapy Model

scholarly journals Model‐Based Comparison of Dose‐Response Profiles of Tofacitinib in Japanese Versus Western Rheumatoid Arthritis Patients

2019 ◽  
Vol 60 (2) ◽  
pp. 198-208
Author(s):  
Misaki Suzuki ◽  
Satoshi Shoji ◽  
So Miyoshi ◽  
Sriram Krishnaswami
Keyword(s):  
Rheumatoid Arthritis ◽  
Dose Response ◽  
Model Based ◽  
Response Profiles

scholarly journals Toward Overcoming Treatment Failure in Rheumatoid Arthritis

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhuqian Wang ◽  
Jie Huang ◽  
Duoli Xie ◽  
Dongyi He ◽  
Aiping Lu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Treatment Failure ◽  
Precision Medicine ◽  
Bone Erosion ◽  
Medical Model ◽  
Autoimmune Disorder ◽  
Trial And Error ◽  
Effector Cells ◽  
The Past ◽  
Tailored Approach

Rheumatoid arthritis (RA) is an autoimmune disorder characterized by inflammation and bone erosion. The exact mechanism of RA is still unknown, but various immune cytokines, signaling pathways and effector cells are involved. Disease-modifying antirheumatic drugs (DMARDs) are commonly used in RA treatment and classified into different categories. Nevertheless, RA treatment is based on a “trial-and-error” approach, and a substantial proportion of patients show failed therapy for each DMARD. Over the past decades, great efforts have been made to overcome treatment failure, including identification of biomarkers, exploration of the reasons for loss of efficacy, development of sequential or combinational DMARDs strategies and approval of new DMARDs. Here, we summarize these efforts, which would provide valuable insights for accurate RA clinical medication. While gratifying, researchers realize that these efforts are still far from enough to recommend specific DMARDs for individual patients. Precision medicine is an emerging medical model that proposes a highly individualized and tailored approach for disease management. In this review, we also discuss the potential of precision medicine for overcoming RA treatment failure, with the introduction of various cutting-edge technologies and big data.

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