scholarly journals Model‐Based Comparison of Dose‐Response Profiles of Tofacitinib in Japanese Versus Western Rheumatoid Arthritis Patients

2019 ◽  
Vol 60 (2) ◽  
pp. 198-208
Author(s):  
Misaki Suzuki ◽  
Satoshi Shoji ◽  
So Miyoshi ◽  
Sriram Krishnaswami
Keyword(s):  
Rheumatoid Arthritis ◽  
Dose Response ◽  
Model Based ◽  
Response Profiles

scholarly journals PV-0314: Model Based Radiotherapy: Submandibular Dose-Response NTCP-curve Based on Objective Measurements

2018 ◽  
Vol 127 ◽  
pp. S165
Author(s):  
C. Terhaard ◽  
J. Vermaire ◽  
T. Dijkema ◽  
M. Philippens ◽  
P. Braam ◽  
...  
Keyword(s):  
Dose Response ◽  
Objective Measurements ◽  
Model Based

Number of parity and the risk of rheumatoid arthritis in women: A dose-response meta-analysis of observational studies

2017 ◽  
Vol 43 (9) ◽  
pp. 1428-1440 ◽  
Author(s):  
Lei Ren ◽  
Peng Guo ◽  
Qiao-Mei Sun ◽  
Hong Liu ◽  
Yu Chen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Dose Response ◽  
Observational Studies ◽  
Meta Analysis

scholarly journals Body Mass Index and the Risk of Rheumatoid Arthritis: An Updated Dose-Response Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Xia Feng ◽  
Xizhu Xu ◽  
Yanjun Shi ◽  
Xuezhen Liu ◽  
Huamin Liu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Body Mass Index ◽  
Body Mass ◽  
Dose Response ◽  
Meta Analysis ◽  
Prevention Strategy ◽  
Sensitivity Analyses ◽  
Significant Heterogeneity ◽  
Nonlinear Relationship ◽  
Increased Risk

Background. Extensive studies have been carried out to investigate the association between obesity and the risk of rheumatoid arthritis (RA); however, the results of the current reported original studies remain inconsistent. This study aimed to clarify the relationship between body mass index and rheumatoid arthritis by conducting an updated overall and dose-response meta-analysis. Methods. The relevant literature was searched using the PubMed and Embase databases (through 20 September 2018) to identify all eligible published studies. Random-effect models and dose-response meta-analyses were used to estimate the pooled risk ratio (RR) with a 95% confidence interval (CI). Subgroup analyses were also conducted based on the characteristics of the participants. Sensitivity analyses and publication bias tests were also performed to explore potential heterogeneity and bias in the meta-analysis. Results. Sixteen studies that included a total of 406,584 participants were included in the meta-analysis. Compared to participants with normal weight, the pooled RRs of rheumatoid arthritis were 1.12 (95% CI, 1.04-1.20) in overweight and 1.23 (95% CI, 1.09-1.39) in obese participants. There was evidence of a nonlinear relationship between body mass index (BMI) and RA (P  for nonlinearity less than 0.001 in the overall meta-analysis, P for nonlinearity=0.025 in the case-control studies, P for nonlinearity=0.0029 in the cohort studies). No significant heterogeneity was found among studies (I2=10.9% for overweight and I2=45.5% for obesity). Conclusion. The overall and dose-response meta-analysis showed that increased BMI was associated with an increased risk for rheumatoid arthritis, which might present a prevention strategy for the prevention or control of rheumatoid arthritis. The nonlinear relationship between BMI and RA might present a personal prevention strategy for RA.

scholarly journals Nonlinear model-based estimates of IC50 for studies involving continuous therapeutic dose–response data

2008 ◽  
Vol 29 (6) ◽  
pp. 878-886 ◽  
Author(s):  
Robert H. Lyles ◽  
Cliff Poindexter ◽  
Angelo Evans ◽  
Milton Brown ◽  
Carlton R. Cooper
Keyword(s):  
Nonlinear Model ◽  
Dose Response ◽  
Therapeutic Dose ◽  
Response Data ◽  
Model Based

Lumiracoxib in the treatment of osteoarthritis, rheumatoid arthritis and acute postoperative dental pain: results of three dose-response studies

2005 ◽  
Vol 21 (1) ◽  
pp. 151-161 ◽  
Author(s):  
Thomas J. Schnitzer ◽  
James R. Fricke ◽  
Xavier Gitton ◽  
Sumedha Jayawardene ◽  
Victor S. Sloan
Keyword(s):  
Rheumatoid Arthritis ◽  
Dose Response ◽  
Dental Pain ◽  
Postoperative Dental Pain

A Dose–Response Meta-Analysis for Quantifying Relative Efficacy of Biologics in Rheumatoid Arthritis

2011 ◽  
Vol 90 (6) ◽  
pp. 828-835 ◽  
Author(s):  
J W Mandema ◽  
D H Salinger ◽  
S W Baumgartner ◽  
M A Gibbs
Keyword(s):  
Rheumatoid Arthritis ◽  
Dose Response ◽  
Meta Analysis ◽  
Relative Efficacy
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