scholarly journals Clinical Efficacy and Residue Depletion of 10% Enrofloxacin Enteric-Coated Granules in Pigs

2017 ◽  
Vol 8 ◽  
Author(s):  
Zhixin Lei ◽  
Qianying Liu ◽  
Bing Yang ◽  
Jincheng Xiong ◽  
Kun Li ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Residue Depletion ◽  
Enteric Coated ◽  
Coated Granules

scholarly journals Effect of water temperature on a simple suspension method for lansoprazole orally disintegrating tablets

2019 ◽  
Vol 15 (1) ◽  
pp. 4-9
Author(s):  
Sumio Chono ◽  
Megumi Matsui ◽  
Katsuki Nakamura
Keyword(s):  
Physical Properties ◽  
Water Temperature ◽  
Gastric Acid ◽  
Warm Water ◽  
Orally Disintegrating Tablets ◽  
Acid Environment ◽  
Enteric Coated ◽  
Pass Through ◽  
Lukewarm Water ◽  
Coated Granules

In this study, we examined the physical properties, including disintegration, passage through a nasogastric administration tube, and acidoresistance, of one branded and five generic formulations of lansoprazole orally disintegrating (OD) tablets containing enteric-coated granules to examine the feasibility of a simple suspension method. The generic tablets immediately disintegrated in warm (55°C) and lukewarm water (35°C) and released the enteric-coated granules, which passed through an administration tube. Moreover, the released enteric-coated granules were stable under a simulated gastric acid environment. However, although the branded tablet disintegrated in warm water, the released enteric-coated granules formed aggregates that did not pass through the administration tube. Meanwhile, the granules released from the branded tablet in lukewarm water did not form aggregates. The present study demonstrated the applicability of a simple suspension method using warm or lukewarm water for generic lansoprazole OD tablets. Additionally, the method is applicable to branded lansoprazole OD tablets using lukewarm water.

scholarly journals Prolonged gastric stasis of enteric-coated granules

2009 ◽  
Vol 2009 (jun01 1) ◽  
pp. bcr0820080622-bcr0820080622
Author(s):  
Y. Matsukawa ◽  
I. Hayashi
Keyword(s):  
Gastric Stasis ◽  
Enteric Coated ◽  
Coated Granules

scholarly journals Nateglinide Controlled Release Tablet Containing Compressionable Enteric Coated Granules

2010 ◽  
Vol 58 (9) ◽  
pp. 1136-1141 ◽  
Author(s):  
Chisato Makino ◽  
Hidetoshi Sakai ◽  
Akira Yabuki
Keyword(s):  
Controlled Release ◽  
Enteric Coated ◽  
Coated Granules ◽  
Release Tablet

Preparation of alginate/chitosan microcapsules and enteric coated granules of mistletoe lectin

2004 ◽  
Vol 27 (1) ◽  
pp. 118-126 ◽  
Author(s):  
Su-Yun Lyu ◽  
Young-Ju Kwon ◽  
Hye-Jin Joo ◽  
Won-Bong Park
Keyword(s):  
Mistletoe Lectin ◽  
Enteric Coated ◽  
Coated Granules

scholarly journals Preparation and preliminary quality evaluation of aspirin/L-glutamate compound pellets

2021 ◽  
Vol 32 (9) ◽  
Author(s):  
Mengchang Xu ◽  
Fenglin Liu ◽  
Wenhu Zhou ◽  
Binsheng He ◽  
Songwen Tan
Keyword(s):  
Quality Evaluation ◽  
Quality Analysis ◽  
Analysis Method ◽  
Two Phase ◽  
Gastrointestinal Damage ◽  
Fluidized Bed Coating ◽  
Phase Compound ◽  
Enteric Coated ◽  
Extrusion Spheronization ◽  
Coated Granules

AbstractL-glutamate is an important component of protein. It can prevent gastrointestinal damage caused by NSAIDs. We constructed two-phase enteric-coated granules of aspirin and L-glutamate compound by extrusion spheronization method and fluidized bed coating. The subliminal effective dose of L-glutamate is 100 mg/kg tested by model of gastric ulcer of rats induced by aspirin and drug administration. HPLC-UV and UV–Vis methods were adopted to determine content and cumulative release of aspirin and L-glutamate as quality analysis method indexes. The prescription and process optimization were carried out with yield, sphericity and dissolution. The two-phase compound granules have good sphericity of 0.93 ± 0.05 (aspirin pellets) and 0.94 ± 0.02 (L-glutamate pellets), content of salicylic acid (0.24 ± 0.03)%, dissolution of aspirin (2.36 ± 0.11)%. Quality evaluation and preliminary stability meet the commercial requirements. The stored environment of compound preparation should be sealed in a cool and dark place.

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