scholarly journals Nateglinide Controlled Release Tablet Containing Compressionable Enteric Coated Granules

2010 ◽  
Vol 58 (9) ◽  
pp. 1136-1141 ◽  
Author(s):  
Chisato Makino ◽  
Hidetoshi Sakai ◽  
Akira Yabuki
Keyword(s):  
Controlled Release ◽  
Enteric Coated ◽  
Coated Granules ◽  
Release Tablet

Preparation and characterization of metformin hydrochloride controlled-release tablet using fatty acid coated granules

2020 ◽  
Vol 46 (5) ◽  
pp. 852-860
Author(s):  
Ji-Hyun Kang ◽  
Myung-Hee Chun ◽  
Mi-Seo Cho ◽  
Yong-Bin Kwon ◽  
Jae-Cheol Choi ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Controlled Release ◽  
Metformin Hydrochloride ◽  
Coated Granules ◽  
Release Tablet

scholarly journals Influence of Splitting on Dissolution Properties of Metoprolol Tablets

2009 ◽  
Vol 9 (3) ◽  
pp. 245-249 ◽  
Author(s):  
Edina Vranić ◽  
Alija Uzunović
Keyword(s):  
Controlled Release ◽  
Extended Release ◽  
Release Formulation ◽  
Extended Release Formulation ◽  
Dissolution Properties ◽  
Tablet Formulations ◽  
Score Line ◽  
Adequate Design ◽  
Release Tablet

The objective of this work was to compare several profiles of dissolution data for metoprolol controlled release tablet formulations in order to identify possible changes in dissolution profiles of whole and scored tablets. Adequate design of score lines (on one or both sides) as well as the technology of preparation of tablet mixtures ensure forming a score line of adequate thickness, shape, size, curvature. According to the obtained results, this type of extended release formulation is eligible for splitting and use in therapy either as a whole or scored tablets.

An in Vivo Single- and Multiple-Dose Study of Several Marketed Brands of Conventional and Controlled-Release Theophylline

1984 ◽  
Vol 18 (2) ◽  
pp. 147-153 ◽  
Author(s):  
Jeffrey A. Kotzan ◽  
Joseph V. Vallner ◽  
James T. Stewart ◽  
Irwin L. Honigberg ◽  
W.J. Brown
Keyword(s):  
Single Dose ◽  
Controlled Release ◽  
Multiple Dose ◽  
Healthy Adult ◽  
Dosage Forms ◽  
Adult Males ◽  
Single Dose Study ◽  
Multiple Dose Study ◽  
Dose Study ◽  
Release Tablet

In a single-dose study, 18 healthy adult males consumed each of six dosage forms of theophylline. A conventional-release tablet, a syrup, and four competing brands of controlled-release theophylline were studied. Serial serum samples were obtained and analyzed via high pressure liquid chromatography (HPLC). After achieving steady state, 15 healthy adult males consumed each of five dosage forms of theophylline in a multiple-dose study. Serial blood samples were obtained between 0 and 72 hours and subjected to analysis with HPLC. The results indicated that the controlled-release products were not bioequivalent, although they achieved longer time-to-peak values than did the immediate-release syrup and the conventional-release tablet. A single sustained-release product was uniquely different on most pharmacokinetic parameters when compared with the remaining three controlled-release products. In general, the dosage form variation exceeded the individual subject variation on the single-dose study, but the opposite was true for the multiple-dose study.

scholarly journals A Cyclodextrin-Based Controlled Release System in the Simulation of In Vitro Small Intestine

Molecules ◽  
2020 ◽  
Vol 25 (5) ◽  
pp. 1212
Author(s):  
Danni Zheng ◽  
Liuxi Xia ◽  
Hangyan Ji ◽  
Zhengyu Jin ◽  
Yuxiang Bai
Keyword(s):  
Complex System ◽  
Small Intestine ◽  
Controlled Release ◽  
Glucose Production ◽  
Scanning Calorimetry ◽  
Release System ◽  
In Vitro Simulation ◽  
Controlled Release System ◽  
Enteric Coated

A novel cyclodextrin (CD)-based controlled release system was developed in the small intestine to control the rate of drug release, on the premise of enteric-coated tablets. The system was designed based on the enzymes exogenous β-cyclodextrin glycosyltransferase (β-CGTase) and endogenous maltase-glucoamylase (MG), wherein MG is secreted in the small intestine and substituted by a congenerous amyloglucosidase (AG). The vanillin-/curcumin-β-CD complexes were prepared and detected by Fourier transform infrared (FT-IR), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC), and host CD degradation was measured based on the glucose yield. The combination of β-CGTase and AG was also functional in the CD complex system. The variations in the concentrations of added β-CGTase, with AG constantly in excess, could effectively alter the rate of host CD degradation and guest release by monitoring glucose production and color disappearance, thus, demonstrating that guest release in the CD complex system could be precisely controlled by changing the amount of β-CGTase used. Thus, the in vitro simulation of the system indicated that a novel controlled release system, based on endogenous MG, could be established in the small intestine. The CD-based controlled release system can be potentially applied in drug delivery and absorption in the small intestine.

scholarly journals Development of a Novel Controlled-Release Tablet of Pregabalin: Formulation Variation and Pharmacokinetics in Dogs and Humans

2020 ◽  
Vol Volume 14 ◽  
pp. 445-456
Author(s):  
Kyung Hun Kim ◽  
Seo Hyun Lim ◽  
Cho Rok Shim ◽  
Junsung Park ◽  
Woo Heon Song ◽  
...  
Keyword(s):  
Controlled Release ◽  
Release Tablet

scholarly journals Effect of water temperature on a simple suspension method for lansoprazole orally disintegrating tablets

2019 ◽  
Vol 15 (1) ◽  
pp. 4-9
Author(s):  
Sumio Chono ◽  
Megumi Matsui ◽  
Katsuki Nakamura
Keyword(s):  
Physical Properties ◽  
Water Temperature ◽  
Gastric Acid ◽  
Warm Water ◽  
Orally Disintegrating Tablets ◽  
Acid Environment ◽  
Enteric Coated ◽  
Pass Through ◽  
Lukewarm Water ◽  
Coated Granules

In this study, we examined the physical properties, including disintegration, passage through a nasogastric administration tube, and acidoresistance, of one branded and five generic formulations of lansoprazole orally disintegrating (OD) tablets containing enteric-coated granules to examine the feasibility of a simple suspension method. The generic tablets immediately disintegrated in warm (55°C) and lukewarm water (35°C) and released the enteric-coated granules, which passed through an administration tube. Moreover, the released enteric-coated granules were stable under a simulated gastric acid environment. However, although the branded tablet disintegrated in warm water, the released enteric-coated granules formed aggregates that did not pass through the administration tube. Meanwhile, the granules released from the branded tablet in lukewarm water did not form aggregates. The present study demonstrated the applicability of a simple suspension method using warm or lukewarm water for generic lansoprazole OD tablets. Additionally, the method is applicable to branded lansoprazole OD tablets using lukewarm water.

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