scholarly journals Targeting Strategies for Renal Cell Carcinoma: From Renal Cancer Cells to Renal Cancer Stem Cells

2016 ◽  
Vol 7 ◽  
Author(s):  
Zhi-xiang Yuan ◽  
Jingxin Mo ◽  
Guixian Zhao ◽  
Gang Shu ◽  
Hua-lin Fu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Renal Cell Carcinoma ◽  
Cancer Stem Cells ◽  
Cell Carcinoma ◽  
Cancer Cells ◽  
Renal Cancer ◽  
Renal Cell ◽  
Renal Cancer Stem Cells

Effect of host immunity on metastatic potential in renal cell carcinoma: the assessment of optimal in vivo models to study metastatic behavior of renal cancer cells

Tumor Biology ◽  
2012 ◽  
Vol 33 (2) ◽  
pp. 551-559 ◽  
Author(s):  
Minoru Kobayashi ◽  
Tatsuo Morita ◽  
Nicole A. L. Chun ◽  
Aya Matsui ◽  
Masafumi Takahashi ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cancer Cells ◽  
Renal Cancer ◽  
Renal Cell ◽  
Metastatic Potential ◽  
Host Immunity ◽  
In Vivo Models ◽  
Metastatic Behavior

scholarly journals Komórki macierzyste raka nerki – Pochodzenie i znaczenie

2019 ◽  
Vol 65 (2) ◽  
pp. 95-102
Author(s):  
Łukasz Szymanski ◽  
Igor Helbrecht ◽  
Michał Fiedorowicz ◽  
Damian Matak ◽  
Ewa Bartnik ◽  
...  
Keyword(s):  
Stem Cells ◽  
Renal Cell Carcinoma ◽  
Cancer Stem Cells ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma

Raki stanowią 85% guzów nerki. W Polsce każdego roku raka nerki rozpoznaje się u prawie czterech tysięcy osób, a ponad dwa tysiące z nich umiera. Znanych jest kilka rodzajów raka nerki, spośród których najczęściej występującym jest rak jasnokomórkowy (ang. clear cell Renal Cell Carcinoma; ccRCC), który występuje w 80-90 proc. wszystkich przypadków raka nerki. ccRCC należy do nowotworów opornych na leczenie chemiczne i radioterapię. Coraz więcej danych wskazuje iż masa nowotworu powstaje w efekcie podziałów i różnicowania niewielkiej liczby komórek zwanych komórkami macierzystymi nowotworu (komórkami inicjującymi guz ang. cancer stem cells - CSC). CSC są nie tylko odpowiedzialne za rozwój nowotworu, ale także za wznowę, progresję choroby i jej oporność na chemio- i radioterapię. W pracy omówiono pochodzenie CSC w raku nerki, ze szczególnym uwzględnieniem podtypu jasnokomórkowego.

scholarly journals Culture in embryonic kidney serum and xeno-free media as renal cell carcinoma and renal cell carcinoma cancer stem cells research model

2018 ◽  
Vol 70 (2) ◽  
pp. 761-782 ◽  
Author(s):  
Krzysztof M. Krawczyk ◽  
Damian Matak ◽  
Lukasz Szymanski ◽  
Cezary Szczylik ◽  
Camillo Porta ◽  
...  
Keyword(s):  
Stem Cells ◽  
Renal Cell Carcinoma ◽  
Cancer Stem Cells ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Research Model ◽  
Free Media

scholarly journals Circular RNA circMTO1 Suppresses RCC Cancer Cell Progression via miR9/LMX1A Axis

2020 ◽  
Vol 19 ◽  
pp. 153303382091428
Author(s):  
Kecheng Li ◽  
Cheng-Liang Wan ◽  
Yan Guo
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Proliferation ◽  
Cell Carcinoma ◽  
Cancer Cells ◽  
Renal Cancer ◽  
Renal Cell ◽  
Target Genes ◽  
Cell Function ◽  
Circular Rnas ◽  
Promoting Effect

Renal cell carcinoma is one of the most common kidney cancer, which accounts almost 90% of the adult renal malignancies worldwide. In recent years, a new class of endogenous noncoding RNAs, circular RNAs, exert important roles in cell function and certain types of pathological responses, especially in cancers, generally by acting as a microRNA sponge. Circular RNAs could act as sponge to regulate the microRNA and the target genes. However, the knowledge about circular RNAs in renal cell carcinoma remains unclear so far. In the research, we selected a highly expressed novel circular RNAs named circMTO1 in renal cell carcinomas. We investigated the roles of circMTO1 and found that circMTO1 overexpression could suppress cell proliferation and metastases in both A497 and 786-O renal cancer cells, while silencing of circMTO1 could promote the progression in SN12C and OS-RC-2 renal cancer cells. The study showed that circMTO1 acted as miR9 and miR223 sponge and inhibited their levels. Furthermore, silencing of circMTO1 in renal cell carcinoma could downregulate LMX1A, the target of miR-9, resulting in the promotion of renal cell carcinoma cell proliferation and invasion. In addition, LMX1A expression suppression induced by transfection of miR9 mimics confirmed that miR9 exerted its function in renal cell carcinoma by regulating LMX1A expression. What’s more, miR9 inhibitor and LMX1A overexpression could block the tumor-promoting effect of circMTO1 silencing. In conclusion, circMTO1 suppresses renal cell carcinoma progression by circMTO1/miR9/ LMX1A, indicating that circMTO1 may be a potential target in renal cell carcinoma therapy.

scholarly journals CD103-positive CSC exosome promotes EMT of clear cell renal cell carcinoma: role of remote MiR-19b-3p

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Lu Wang ◽  
Guang Yang ◽  
Danfeng Zhao ◽  
Jiaqi Wang ◽  
Yang Bai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cancer Cells ◽  
Lung Metastasis ◽  
Renal Cell ◽  
Clear Cell ◽  
Epithelial Mesenchymal Transition ◽  
Cell Renal Cell Carcinoma ◽  
Mesenchymal Transition

Abstract Background Clear cell renal cell carcinoma (CCRCC) is characterized by a highly metastatic potential. The stromal communication between stem cells and cancer cells critically influences metastatic dissemination of cancer cells. Methods The effect of exosomes isolated from cancer stem cells (CSCs) of CCRCC patients on the progress of epithelial-mesenchymal transition (EMT) and lung metastasis of CCRCC cells were examined. Results CSCs exosomes promoted proliferation of CCRCC cells and accelerated the progress of EMT. Bioactive miR-19b-3p transmitted to cancer cells by CSC exosomes induced EMT via repressing the expression of PTEN. CSCs exosomes derived from CCRCC patients with lung metastasis produced the strongest promoting effect on EMT. Notably, CD103+ CSC exosomes were enriched in tumor cells and in lung as well, highlighting the organotropism conferred by CD103. In addition, CD103+ exosomes were increased in blood samples from CCRCC patients with lung metastasis. Conclusions CSC exosomes transported miR-19b-3p into CCRCC cells and initiated EMT promoting metastasis. CD103+ acted to guide CSC exosomes to target cancer cells and organs, conferring the higher metastatic capacity of CCRCC to lungs, suggesting CD103+ exosomes as a potential metastatic diagnostic biomarker. Graphical abstract ᅟ

scholarly journals Cancer stem cells are underestimated by standard experimental methods in clear cell renal cell carcinoma

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Craig Gedye ◽  
Danylo Sirskyj ◽  
Nazleen C. Lobo ◽  
Jalna Meens ◽  
Elzbieta Hyatt ◽  
...  
Keyword(s):  
Stem Cells ◽  
Renal Cell Carcinoma ◽  
Cancer Stem Cells ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Experimental Methods ◽  
Cell Renal Cell Carcinoma

Spheres derived from the human SK-RC-42 renal cell carcinoma cell line are enriched in cancer stem cells

2010 ◽  
Vol 299 (2) ◽  
pp. 150-160 ◽  
Author(s):  
Yong Zhong ◽  
Kaopeng Guan ◽  
Sujuan Guo ◽  
Chunxia Zhou ◽  
Dongmei Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Renal Cell Carcinoma ◽  
Cancer Stem Cells ◽  
Cell Carcinoma ◽  
Cell Line ◽  
Renal Cell ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Renal Cell Carcinoma Cell

Isolation and Characterization of Cancer Stem Cells in Renal Cell Carcinoma

2014 ◽  
Vol 82 (1) ◽  
pp. 46-53 ◽  
Author(s):  
Giuseppe Lucarelli ◽  
Vanessa Galleggiante ◽  
Monica Rutigliano ◽  
Antonio Vavallo ◽  
Pasquale Ditonno ◽  
...  
Keyword(s):  
Stem Cells ◽  
Renal Cell Carcinoma ◽  
Cancer Stem Cells ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Isolation And Characterization
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