scholarly journals New Approaches to Overcome Transport Related Drug Resistance in Trypanosomatid Parasites

2016 ◽  
Vol 7 ◽  
Author(s):  
Jose A. Garcia-Salcedo ◽  
Juan D. Unciti-Broceta ◽  
Javier Valverde-Pozo ◽  
Miguel Soriano
Keyword(s):  
Drug Resistance ◽  
New Approaches ◽  
Trypanosomatid Parasites ◽  
Related Drug

Methods to unravel the role of HDAC10 in autophagy-related drug resistance

2015 ◽  
Vol 227 (06/07) ◽  
Author(s):  
J Fabian ◽  
J Ridinger ◽  
O Witt ◽  
I Oehme
Keyword(s):  
Drug Resistance ◽  
Related Drug

scholarly journals Aurora Kinase B Inhibition: A Potential Therapeutic Strategy for Cancer

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1981
Author(s):  
Naheed Arfin Borah ◽  
Mamatha M. Reddy
Keyword(s):  
Drug Resistance ◽  
Cell Cycle Progression ◽  
Therapeutic Strategy ◽  
Tumor Development ◽  
Aurora Kinase ◽  
Aurora Kinase B ◽  
Development Therapy ◽  
Chromosomal Passenger ◽  
Combination Studies ◽  
Related Drug

Aurora kinase B (AURKB) is a mitotic serine/threonine protein kinase that belongs to the aurora kinase family along with aurora kinase A (AURKA) and aurora kinase C (AURKC). AURKB is a member of the chromosomal passenger protein complex and plays a role in cell cycle progression. Deregulation of AURKB is observed in several tumors and its overexpression is frequently linked to tumor cell invasion, metastasis and drug resistance. AURKB has emerged as an attractive drug target leading to the development of small molecule inhibitors. This review summarizes recent findings pertaining to the role of AURKB in tumor development, therapy related drug resistance, and its inhibition as a potential therapeutic strategy for cancer. We discuss AURKB inhibitors that are in preclinical and clinical development and combination studies of AURKB inhibition with other therapeutic strategies.

scholarly journals A novel chemical, STF-083010, reverses tamoxifen-related drug resistance in breast cancer by inhibiting IRE1/XBP1

Oncotarget ◽  
2015 ◽  
Vol 6 (38) ◽  
pp. 40692-40703 ◽  
Author(s):  
Jie Ming ◽  
Shengnan Ruan ◽  
Mengyi Wang ◽  
Dan Ye ◽  
Ningning Fan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Related Drug

scholarly journals 2-oxo-1,2-dihydroquinoline-4-carboxylic acid derivatives as potent modulators of ABCB1-related drug resistance of mouse T-lymphoma cells

2020 ◽  
Vol 29 ◽  
pp. 100501
Author(s):  
Yassir Filali Baba ◽  
Houria Misbahi ◽  
Youssef Kandri Rodi ◽  
Younes Ouzidan ◽  
El Mokhtar Essassi ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Carboxylic Acid ◽  
Lymphoma Cells ◽  
T Lymphoma Cells ◽  
Related Drug ◽  
T Lymphoma
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