scholarly journals Mechanism and Physiologic Significance of the Suppression of Cholesterol Esterification in Human Interstitial Fluid

2016 ◽  
Vol 7 ◽  
Author(s):  
Norman E. Miller ◽  
Waldemar L. Olszewski ◽  
Irina P. Miller ◽  
Mahmud N. Nanjee
Keyword(s):  
Interstitial Fluid ◽  
Cholesterol Esterification ◽  
Human Interstitial Fluid

scholarly journals Metabolomics of Interstitial Fluid, Plasma and Urine in Patients with Arterial Hypertension: New Insights into the Underlying Mechanisms

Diagnostics ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 936
Author(s):  
Angelika Chachaj ◽  
Rafał Matkowski ◽  
Gerhard Gröbner ◽  
Andrzej Szuba ◽  
Ilona Dudka
Keyword(s):  
Arterial Hypertension ◽  
Interstitial Fluid ◽  
Ethical Issues ◽  
Proton Nuclear Magnetic Resonance ◽  
Axillary Lymph ◽  
Oncological Patients ◽  
Simultaneous Evaluation ◽  
Human Interstitial Fluid ◽  
Clear Differentiation ◽  
Underlying Mechanisms

There is growing evidence that lymphatic system plays a pivotal role in the pathogenesis of hypertension. Here, for the first time, the metabolome of interstitial fluid is analyzed in patients with arterial hypertension. Due to ethical issues to obtain human interstitial fluid samples, this study included only oncological patients after axillary lymph node dissection (ALND). These patients were matched into hypertensive (n = 29) and normotensive (n = 35) groups with similar oncological status. Simultaneous evaluation of interstitial fluid, plasma, and urine was obtained by combining high-resolution proton nuclear magnetic resonance (1H NMR) spectroscopy with chemometric analysis. Orthogonal partial least squares discriminant analysis (OPLS-DA) provided a clear differentiation between the hypertension and normotensive group, with the discrimination visible in each biofluid. In interstitial fluid nine potential metabolomic biomarkers for hypertension could be identified (creatinine, proline, pyroglutamine, glycine, alanine, 1-methylhistidine, the lysyl group of albumin, threonine, lipids), seven distinct markers in plasma (creatinine, mannose, isobutyrate, glycine, alanine, lactate, acetate, ornithine), and seven respectively in urine (methylmalonate, citrulline, phenylacetylglycine, fumarate, citrate, 1-methylnicotinamide, trans-aconitate). Biomarkers in plasma and urine allowed for the identification of specific biochemical pathways involved in hypertension, as previously suggested. Analysis of the interstitial fluid metabolome provided additional biomarkers compared to plasma or urine. Those biomarkers reflected primarily alterations in the metabolism of lipids and amino acids, and indicated increased levels of oxidative stress/inflammation in patients with hypertension.

Effect of Praseodymium(III) on Zinc(II) Species in Human Interstitial Fluid

2005 ◽  
Vol 107 (2) ◽  
pp. 101-112
Author(s):  
Haiyuan Zhang ◽  
Jinping Wang ◽  
Xin Lu ◽  
Kuiyue Yang ◽  
Chunji Niu
Keyword(s):  
Interstitial Fluid ◽  
Human Interstitial Fluid

A Method for Measurement of Antibiotics in Human Interstitial Fluid

1972 ◽  
Vol 126 (5) ◽  
pp. 492-497 ◽  
Author(s):  
J. S. Tan ◽  
A. Trott ◽  
J. P. Phair ◽  
C. Watanakunakorn
Keyword(s):  
Interstitial Fluid ◽  
Human Interstitial Fluid

Computer Simulation for Effect of Pr(III) on Ca(II) Speciation in Human Interstitial Fluid

2003 ◽  
Vol 94 (2) ◽  
pp. 131-140 ◽  
Author(s):  
Haiyuan Zhang ◽  
Xing Lu ◽  
Jinping Wang ◽  
Kuiyue Yang ◽  
Chunji Niu
Keyword(s):  
Computer Simulation ◽  
Interstitial Fluid ◽  
Human Interstitial Fluid

scholarly journals Comparison of apoprotein B of low density lipoproteins of human interstitial fluid and plasma

1984 ◽  
Vol 222 (1) ◽  
pp. 49-55 ◽  
Author(s):  
J L Hong ◽  
J Pflug ◽  
D Reichl
Keyword(s):  
Interstitial Fluid ◽  
Polyacrylamide Gel Electrophoresis ◽  
Sodium Dodecyl ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Very Low Density Lipoproteins ◽  
Apo B ◽  
Apoprotein B ◽  
Human Interstitial Fluid ◽  
Nonionic Detergent

Virtually all apoprotein B (apoB)-containing lipoproteins of the peripheral interstitial fluid of subjects with primary lymphoedema float in the ultracentrifugal field in the density interval 1.019-1.063 g/ml; in this respect they are similar to plasma low-density lipoproteins (LDL). 2. Virtually all apo-B-containing lipoproteins of interstitial fluid migrate in the electrophoretic field with pre-beta mobility; in this respect they are similar to plasma very-low-density lipoproteins. 3. The apoB of lipoproteins of interstitial fluid does not differ in terms of Mr from apoB-100 of human plasma [Kane, Hardman & Paulus (1980) Proc. Natl. Acad. Sci. U.S.A. 77, 2465-2469] as determined by sodium dodecyl sulphate/polyacrylamide-gel electrophoresis. 4. Both apoB of interstitial fluid and plasma are heterogenous in terms of their charge as determined by isoelectric focusing of their complexes with the nonionic detergent Nonidet P40. ApoB of plasma LDL focuses between pH5.9 and 6.65, and that of interstitial fluid LDL between pH 5.9 and 6.1. Thus the overall charge of apoB of interstitial fluid is more negative than that of its plasma LDL counterpart.

Presence of paraoxonase in human interstitial fluid

FEBS Letters ◽  
1997 ◽  
Vol 416 (3) ◽  
pp. 377-380 ◽  
Author(s):  
Michael I Mackness ◽  
Bharti Mackness ◽  
Sharon Arrol ◽  
Grahame Wood ◽  
Deepak Bhatnagar ◽  
...  
Keyword(s):  
Interstitial Fluid ◽  
Human Interstitial Fluid
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