scholarly journals Milrinone in Enterovirus 71 Brain Stem Encephalitis

2016 ◽  
Vol 7 ◽  
Author(s):  
Shih-Min Wang
2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Shih-Min Wang ◽  
Huan-Yao Lei ◽  
Ching-Chuan Liu

Enterovirus 71 (EV71) is one of the most important causes of herpangina and hand, foot, and mouth disease. It can also cause severe complications of the central nervous system (CNS). Brain stem encephalitis with pulmonary edema is the severe complication that can lead to death. EV71 replicates in leukocytes, endothelial cells, and dendritic cells resulting in the production of immune and inflammatory mediators that shape innate and acquired immune responses and the complications of disease. Cytokines, as a part of innate immunity, favor the development of antiviral and Th1 immune responses. Cytokines and chemokines play an important role in the pathogenesis EV71 brain stem encephalitis. Both the CNS and the systemic inflammatory responses to infection play important, but distinctly different, roles in the pathogenesis of EV71 pulmonary edema. Administration of intravenous immunoglobulin and milrinone, a phosphodiesterase inhibitor, has been shown to modulate inflammation, to reduce sympathetic overactivity, and to improve survival in patients with EV71 autonomic nervous system dysregulation and pulmonary edema.


2015 ◽  
Vol 46 (06) ◽  
pp. 428-430 ◽  
Author(s):  
Annette Hackenberg ◽  
Anne Tio-Gillen ◽  
Annemarie van Rossum ◽  
Christoph Berger ◽  
Bart Jacobs ◽  
...  

2007 ◽  
Vol 78 (1) ◽  
pp. 107-108 ◽  
Author(s):  
D Nystad ◽  
R Salvesen ◽  
E W Nielsen

Author(s):  
Herbert Weissenböck ◽  
Arnt Ebinger ◽  
Anna Maria Gager ◽  
Denise Thaller ◽  
Dirk Höper ◽  
...  

2016 ◽  
Vol 46 (06) ◽  
pp. e1-e1
Author(s):  
Annette Hackenberg ◽  
Anne Tio-Gillen ◽  
Annemarie van Rossum ◽  
Christoph Berger ◽  
Bart Jacobs ◽  
...  

PEDIATRICS ◽  
1977 ◽  
Vol 59 (2) ◽  
pp. 240-243
Author(s):  
Patricia H. Ellison ◽  
Peggy A. Hanson

Herpes simplex virus was isolated from the tracheal aspirate of a 10-year-old boy presenting with acute onset of multiple cranial nerve palsies and a mild right hemiparesis. There was also an elevated herpes complement-fixation titer with decrease in the following weeks. Although the criteria for diagnosis of central nervous system infection by herpes virus have been debated, we propose that this represents a case of brain-stem encephalitis due to herpes simplex infection. The importance of early diagnosis and evaluation of therapy are emphasized by this case in which the patient recovered completely.


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