scholarly journals A Distinct Profile of Tryptophan Metabolism along the Kynurenine Pathway Downstream of Toll-Like Receptor Activation in Irritable Bowel Syndrome

2012 ◽  
Vol 3 ◽  
Author(s):  
Gerard Clarke ◽  
Declan P. McKernan ◽  
Gabor Gaszner ◽  
Eamonn M. Quigley ◽  
John F. Cryan ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Receptor Activation ◽  
Kynurenine Pathway ◽  
Tryptophan Metabolism ◽  
Toll Like Receptor ◽  
Irritable Bowel

scholarly journals Tryptophan Metabolism Along the Kynurenine Pathway Downstream of Toll-like Receptor Stimulation in Peripheral Monocytes

2016 ◽  
Vol 84 (5) ◽  
pp. 262-271 ◽  
Author(s):  
F. Orhan ◽  
M. Bhat ◽  
K. Sandberg ◽  
S. Ståhl ◽  
F. Piehl ◽  
...  
Keyword(s):  
Kynurenine Pathway ◽  
Tryptophan Metabolism ◽  
Toll Like Receptor ◽  
Receptor Stimulation

scholarly journals Corticotropin-Releasing Factor and Toll-Like Receptor Gene Expression Is Associated with Low-Grade Inflammation in Irritable Bowel Syndrome Patients with Depression

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Song Jizhong ◽  
Wang Qiaomin ◽  
Wang Chao ◽  
Li Yanqing
Keyword(s):  
Gene Expression ◽  
Irritable Bowel Syndrome ◽  
Inflammatory Response ◽  
Psychiatric Symptoms ◽  
Corticotropin Releasing Factor ◽  
Low Grade ◽  
Lower Grade ◽  
Toll Like Receptor ◽  
Irritable Bowel ◽  
Low Grade Inflammation

The mechanism of low-grade inflammation in irritable bowel syndrome (IBS) is unclear; our research concentrates on the involvement of the corticotropin-releasing factor (CRF) and Toll-like receptor (TLR) gene expression in the process of low-grade inflammation in IBS patients with depression. This study suggests more IBS patients are presenting with the states of depression and anxiety. IBS patients with depression have shown a lower grade inflammatory response and an imbalance of the inflammatory response. CRF1, CRF2, TLR2, and TLR4 in IBS patients with depression are significantly higher than those without depression and controls. Thus, activation of the CRF-TLR associated pathways produces an inflammatory reaction, which can concurrently affect the digestive tract and the CNS and induce the corresponding digestive and psychiatric symptoms.

scholarly journals Characterization of kynurenine pathway in patients with diarrhea-predominant irritable bowel syndrome

2020 ◽  
Author(s):  
Pingping Li ◽  
Jimin Zheng ◽  
Yun Bai ◽  
Dingxin Wang ◽  
Zijin Cui ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Mood Disorders ◽  
High Performance ◽  
Depression Scale ◽  
Kynurenine Pathway ◽  
Self Rating ◽  
Symptom Severity Scale ◽  
Liquid Chromatography Tandem Mass ◽  
Intestinal Symptoms ◽  
Irritable Bowel

Our objectives are to demonstrate whether the kynurenine pathway is activated in diarrhea-type irritable bowel syndrome (IBS-D) patients, and whether the neurotoxic metabolite quinolinic acid (QUIN) is out of balance with the neuroprotective metabolite kynurenic acid (KYNA), and further explore whether this can lead to increase of N-methyl D-aspartate receptor 2B (NMDAR2B) expression in the enteric nervous system and in turn leads to intestinal symptoms and mood disorders. All enrolled healthy controls and patients accepted IBS symptom severity scale (IBS-SSS) score, Self-rating Depression Scale (SDS) and Self-rating Anxiety Scale (SAS) anxiety and depression scores, and also underwent colonoscopy to collect ileum and colonic mucosa specimens. The expression of NMDAR2B in intestinal mucosa was detected by immunofluorescence, and fasting serum was collected to detect the tryptophan (Trp), kynurenine (KYN), KYNA and QUIN by high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). Our results showed that the kynurenine pathway of IBS-D patients was activated. The production of QUIN and KYNA was imbalanced and resulting in an increased NMDAR2B for patients with IBS-D, which may be involved in intestinal symptoms and mood disorders of IBS-D.

scholarly journals Increased Kynurenine Production Following Toll-Like Receptor (TLR) Activation: A Novel Role for Tlr8 in Irritable Bowel Syndrome (IBS)

2011 ◽  
Vol 140 (5) ◽  
pp. S-111 ◽  
Author(s):  
Gerard Clarke ◽  
Declan P. McKernan ◽  
Gabor Gaszner ◽  
Eamonn M. Quigley ◽  
John F. Cryan ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Toll Like Receptor ◽  
Irritable Bowel

scholarly journals Altered peripheral toll-like receptor responses in the irritable bowel syndrome

2011 ◽  
Vol 33 (9) ◽  
pp. 1045-1052 ◽  
Author(s):  
D. P. McKernan ◽  
G. Gaszner ◽  
E. M. Quigley ◽  
J. F. Cryan ◽  
T. G. Dinan
Keyword(s):  
Irritable Bowel Syndrome ◽  
Toll Like Receptor ◽  
Irritable Bowel
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